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Journals / Türk Pediatri Arşivi / 2010 / Cilt: 45 - Sayı: 4

Evaluation of the correlation between plasma amylase and lipase levels and phthalate exposure in pubertal gynecomastia patients

Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi

Elif ÖZMERT
Orhan DERMAN
Kadriye YURDAKÖK
Belma GİRAY
Murat KIZILGÜN
Pınar ERKEKOĞLU
Erdem DURMAZ
Pages
366–370
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Significant negative correlations existed between a-amylase and MEHP levels in gynecomastia (r=-0.388, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and a-amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas.
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Key Findings & Data:Material and Method: The study group was composed of 40 pubertal gynecomastia patients.
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Conclusion & Impact:Significant negative correlations existed between a-amylase and MEHP levels in gynecomastia (r=-0.388, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and a-amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas. Material and Method: The study group was composed of 40 pubertal gynecomastia patients. Plasma phthalate levels (Di(2-ethylhexyl)phthalate, DEHP and mono (2-ethylhexyl) phthalate, MEHP) were determined using HPLC. Plasma lipase and a-amylase levels were measured by using enzymatic colorimetric assay. Results: Plasma DEHP and MEHP levels in gynecomatia patients were higher than the control group significantly. Significant negative correlations existed between a-amylase and MEHP levels in gynecomastia (r=-0.388, p

Özet

Amaç: Bu çalışmanın amacı, endokrin bozucu etkileri bilinen di(2-etilhekzil)fitalat (DEHP) ve metaboliti mono (2-etilhekzil) fitalat (MEHP) plazma düzeylerinin yüksek olduğu belirlenen pubertal jinekomasti hastalarında plazma fitalat düzeyleri ile pankreatik lipaz ve a-amilaz düzeyleri arasındaki ilişkinin incelenmesi ve fitalatların pankreas üzerindeki olası etkilerinin değerlendirilmesidir. Gereç ve Yöntem: Çalışma grubu 40 pubertal jinekomasti hastasından oluşmaktadır. Plazma fitalat düzeyleri DEHP ve MEHP mono (2-etikhekzil) Yüksek basınçlı sıvı kromatografisi (high pressure liquid chromatography) kullanılarak belirlenmiştir. Lipaz ve a-amilaz düzeyleri enzimatik kolorimetrik yöntemle ölçülmüştür. İncelenen değişkenler arasındaki ilişki, ilişki katsayısı saptanarak incelenmiştir. Bulgular: Jinekomasti hastalarındaki plazma DEHP ve MEHP düzeyleri, kontrol grubuna oranla önemli düzeyde yüksek bulunmuştur. Alfa-amilaz ve MEHP düzeyleri arasında jinekomasti hastalarında (r=-0,388, p

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Cite This Article

ÖZMERT, E., DERMAN, O., YURDAKÖK, K., GİRAY, B., KIZILGÜN, M., ERKEKOĞLU, P., DURMAZ, E. (2022). Evaluation of the correlation between plasma amylase and lipase levels and phthalate exposure in pubertal gynecomastia patients. Türk Pediatri Arşivi, Cilt: 45 - Sayı: 4, 366–370. https://ajindex.com/articles/641531

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