Journals / Türk Pediatri Arşivi / 2016 / Cilt: 51 - Sayı: 4

High-dose anti-histamine use and risk factors in children with urticaria

Ürtikerli çocukluklarda yüksek doz antihistaminik kullanımı ve risk etmenleri

Pages
198–203
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged >=10 years (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines.
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Key Findings & Data:The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.
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Conclusion & Impact:Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged >=10 years (p
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods: The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria.Results: The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged >=10 years (p

Özet

Amaç: Çocuklarda ürtiker tedavisinde ilk tercih sedatif olmayan H1antihistaminik ilaçlardır. Bu çalışmada, ürtikerli çocukların değerlendirilmesi ve yüksek doz H1-antihistaminik tedavi gereksinimi ile ilişkili risk etmenlerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Polikliniğimize Ocak 2014-Ocak 2016 tarihleri arasında başvurarak ürtiker tanısı alan çocukların dosya bilgileri tarandı. Hastaların tıbbi özgeçmişleri, eşlik eden atopik hastalıkları, ailesel atopi öyküleri, kullandıkları ilaçlar, antihistaminik ilaçlara verdikleri tedavi yanıtları, kan eozinofil ve bazofil sayıları ile serum total IgE düzeyleri kaydedildi. Ek olarak, kronik ürtikerli çocukların yedi günlük ürtiker aktivite skorları, otoimmün antikor testleri ve deri prik testi sonuçları değerlendirmeye alındı. Bulgular: Akut ve kronik ürtiker tanısı olan çocukların sayıları sırasıyla 138 ve 92 idi. Kronik ürtikerli çocukların yaşı akut ürtikerli çocuklardan yüksekti (p0,05). Kronik ürtikerli çocuklarda kan eozinofil sayısı ile UAS7 arasında negatif yönlü bir korrelasyon saptandı (r=-0,276, p=0,011). Kronik ürtiker ve yüksek doz H1antihistaminik gereksinimi >=10 yaş çocuklarda daha sık görüldü (p

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Cite This Article

AVCİL, S., ERGE, D., UYSAL, P. (2022). High-dose anti-histamine use and risk factors in children with urticaria. Türk Pediatri Arşivi, Cilt: 51 - Sayı: 4, 198–203. https://ajindex.com/articles/641124

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References (4)

  1. Zuberbier T, Aberer W, Asero R, et al. European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization. The EAACI/GA(2) LEN/EDF/WAO Gu- ideline for the definition, classification, diagnosis, and ma- nagement of urticaria: the 2013 revision and update. Allergy 2014; 69: 868-87. [CrossRef ] Kaplan AP. Clinical practice: chronic urticaria and angioede- ma. N Engl J Med 2002; 346: 175-9. [CrossRef ] Sánchez-Borges M, Asero R, Ansotegui IJ, et al. Scientific and Clinical Issues Council. Diagnosis and treatment of urticaria and angioedema: a worldwide perspective. World Allergy Or- gan J 2012; 5: 125-47. [CrossRef ] Hoffmann HJ, Santos AF, Mayorga C, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy 2015; 70: 1393-405. [CrossRef ] Krishnaswamy G, Youngberg G. Acute and chronic urticaria: challenges and considerations for primary care physicians. Postgrad Med 2001; 109: 107-8. [CrossRef ] Asero R. Chronic unremitting urticaria: is the use of antihista- mines above the licensed dose effective? A preliminary study of cetirizine at licensed and above-licensed doses Clin Exp Dermatol 2007; 32: 34-8.
  2. Zuberbier T, Iffländer J, Semmler C, Henz BM. Acute urti- caria: clinical aspects and therapeutic responsiveness. Acta Derm Venereol 1996; 76: 295-7.
  3. Asero R, Tedeschi A. Usefulness of a short course of oral pred- nisone in antihistamine- resistant chronic urticaria: a retros- pective analysis. J Investig Allergol Clin Immunol 2010; 20: 386-90.
  4. Zuberbier T, Asero R, Bindslev-Jensen C, et al. EAACI/GA(2) LEN/EDF/WAO guideline: management of urticaria Allergy 2009; 64: 1427-43. [CrossRef ] Chang KL, Yang YH, Yu HH, Lee JH, Wang LC, Chiang BL. Analysis of serum total IgE, specific IgE and eosinophils in children with acute and chronic urticaria. J Microbiol Immu- nol Infect 2013; 46: 53-8. [CrossRef ] Liu TH, Lin YR, Yang KC, Chou CC, Chang YJ, Wu HP. First attack of acute urticaria in pediatric emergency room. Pediatr Neonatol 2008; 49: 58-64. [CrossRef ] Wananukul S, Chatproedprai S, Tempark T, Phuthongkamt W, Chatchatee P. The natural course of childhood atopic derma- titis: a retrospective cohort study. Asian Pac J Allergy Immu- nol 2015; 33: 161-8. [CrossRef ] Jirapongsananuruk O, Pongpreuksa S, Sangacharoenkit P, Vi- sitsunthorn N, Vichyanond P. Identification of the etiologies of chronic urticaria in children: a pros