AI Summary & Key Takeaways
AI InsightMetaplastic carcinomas of the breast draw attention with thedifferences in their clinical course and the radiological and pathological heterogeneity.
📌 3 Key Takeaways
Abstract
Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and treatment methods of metaplastic breastcarcinoma cases diagnosed at our center in the light of current literature.Material and Method: A total of 38 metaplastic breast cancer cases diagnosed between 2006-2018 at our center were included in the study.The patients were evaluated in terms of age, tumor size, localization, histological grade, hormone profiles (ER, PR, Her2-neu), American JointCommittee on Cancer (AJCC) Tumor, Lymph node status, Metastases (TNM) stage, progression, survival, radiological features, types of surgeryand therapy modalities (chemotherapy and / or radiotherapy).Results: The age of the patients ranged between 32 and 95 years. Pathological evaluation of cases showed that 14 were pure epithelial (IC-NST+ squamous cell carcinoma) and 24 were metaplastic carcinomas with mesenchymal differentiation. Ductal carcinoma in situ (DCIS) wasaccompanying an invasive component in twenty cases. Seventeen patients had lymph node metastasis. Twelve patients developed distantmetastasis. Thirty patients were triple negative for hormone receptors. The mean follow-up period of the patients was 34 months. The estimatedlife expectancy was 116 months. All of the patients received chemotherapy and 28 patients received adjuvant radiotherapy. There was nocorrelation between tumor size and lymph node or distant metastasis in our series. Our findings are consistent with the literature.Conclusion: Metaplastic breast carcinoma is a rare entity among breast carcinomas. Metaplastic carcinomas of the breast draw attention with thedifferences in their clinical course and the radiological and pathological heterogeneity.