Journals / Türk Patoloji Dergisi / 2010 / Cilt: 26 - Sayı: 3

Suudi Arabistan toplumunda invaziv meme kanserlerinde hormon reseptörlerinin HER 2/neu protein ekspresyonu ve histolojik grade ile ilişkisi

Correlation of hormone receptors with HER 2/neu protein expression and the histological grade in invasive breast cancers in a cohort of Saudi Arabia

Pages
209–215
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The expression of estrogen receptor and progestrone receptor were significantly correlated (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Data on hormone receptor and Her2/neu expression in breast cancers from Saudi Arabia and Gulf Region is sparse.
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Key Findings & Data:We undertook this study to describe the patterns of hormone receptor and Her2/neu protein expression in breast carcinoma and compared them with the histological grade at a university hospital in Riyadh.Material and Method: We conducted a retrospective hormone receptor and Her2/neu study on 164 histologically confirmed invasive ductal carcinoma of the breast between the year 2002 and 2008.
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Conclusion & Impact:The expression of estrogen receptor and progestrone receptor were significantly correlated (p
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Data on hormone receptor and Her2/neu expression in breast cancers from Saudi Arabia and Gulf Region is sparse. We undertook this study to describe the patterns of hormone receptor and Her2/neu protein expression in breast carcinoma and compared them with the histological grade at a university hospital in Riyadh.Material and Method: We conducted a retrospective hormone receptor and Her2/neu study on 164 histologically confirmed invasive ductal carcinoma of the breast between the year 2002 and 2008. Immunohistochemical analysis for estrogen receptor, progestrone receptor and Her2/neu was done in all the cases. Fluorescent in situ hybridization (FISH) for Her2/neu gene amplification was performed in all 2+ cases and a few equivocal 1+ and 3+cases by immunohistochemistry. The results were then compared in a blinded fashion. Correlation between Estrogen Receptor, Progesterone Receptor and Her2/neu amplification and grade of tumour were calculated.Result: The prevalence of estrogen receptor, progestrone receptor and Her2/neu overexpression were 64.6%, 57.3% and 35.3% respectively. The expression of estrogen receptor and progestrone receptor were significantly correlated (p

Özet

Amaç: Suudi Arabistan ve Körfez bölgesinde meme kanserlerinde hormon reseptörü ve Her2/neu ekspresyonu ile ilgili veriler azdır. Bu çalışmayı Riyad'da bir üniversite hastanesinde meme kanserlerinde hormon reseptör paternlerini ve Her2/neu protein ekspresyonunu tanımlamak üzere ele aldık ve bunları histolojik grade ile karşılaştırdık.Gereç ve Yöntem: 2002 ve 2008 yılları arasında, histolojik olarak tanısı doğrulanmış 164 meme invaziv duktal karsinoma olgusunda retrospektif olarak hormon reseptörü ve Her2/neu çalışması yaptık. Östrojen reseptörü, progesteron reseptörü ve Her2/neu için immünohistokimyasal analiz tüm olgularda değerlendirildi. İmmünohistokimyasal olarak tüm +2 olgulara ve az sayıdaki şüpheli +1 ve +3 olgulara Her2/neu gen amplifikasyonu için floresan in situ hibridizasyon uygulandı. Daha sonra sonuçlar kör yöntem ile karşılaştırıldı. Östrojen reseptörü, progesteron reseptörü ve Her2/neu ampilifikasyonu ve tümör grade'i arasındaki ilişki değerlendirildi.Bulgular: Östrojen reseptörü, progesteron reseptörü, Her2/neu aşırı ekspresyonunun prevalansı sırasıyla %64.6, %57.3 ve % 35.3 idi. Östrojen reseptörü ve progesteron reseptörü ekspresyonu anlamlı derecede ilişkiliydi (p

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Cite This Article

ARAFAH, M. (2022). Suudi Arabistan toplumunda invaziv meme kanserlerinde hormon reseptörlerinin HER 2/neu protein ekspresyonu ve histolojik grade ile ilişkisi. Türk Patoloji Dergisi, Cilt: 26 - Sayı: 3, 209–215. https://ajindex.com/articles/640796

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