Sentinel nod pozitif meme karsinomunda non-sentinel lenf nodu tutulumunu öngören faktörler

Objective & Hypothesis:Objective: In routine practice, axillary lymph node dissection is performed in early invasive breast cancer patients with positive sentinel node biopsy.

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Key Findings & Data:However, sentinel node is the only involved axillary node in 40-70% of patients, and determining factors that predict axillary non-sentinel node involvement will therefore prevent unnecessary axillary lymph node dissection and decrease morbidity.

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Conclusion & Impact:The percent area of sentinel node occupied by tumor (p

🔬Design:Research Article

📍Scope:2009 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: In routine practice, axillary lymph node dissection is performed in early invasive breast cancer patients with positive sentinel node biopsy. However, sentinel node is the only involved axillary node in 40-70% of patients, and determining factors that predict axillary non-sentinel node involvement will therefore prevent unnecessary axillary lymph node dissection and decrease morbidity. Material and Method: In this study, 119 invasive breast cancer patients with sentinel node metastasis who underwent axillary lymph node dissection between 1998-2009 at our institution were studied. Primary tumor characteristics and features of the metastatic tumors in sentinel nodes, such as microanatomic location, size of metastasis, and the ratio of metastatic tumor area to the total sentinel node area were evaluated. Student's t-test and multivariate logistic regression were used for statistical analysis.Results: The mean age of the patients was 50.7 years (28-80). Forty-three patients (36%) had invasive ductal and 25 patients (21%) had invasive lobular carcinoma. Most of the patients had either pT1 (44%) or pT2 (54%) tumors. Fifty-four patients (45%) had no further positive nodes in the axilla. The metastatic deposits in the sentinel node were subcapsular in 16 patients (13%). The percent area of sentinel node occupied by tumor (p

Özet

Amaç: Rutin uygulamada, sentinel lenf nodu biyopsisi pozitif erken evre invaziv meme kanseri hastalarına aksiller lenf nodu diseksiyonu yapılmaktadır. Ancak hastaların %40-70'inde sentinel lenf nodu tek metastatik aksiller lenf nodu olduğu için, aksiller non-sentinel nod tutulumunu öngören faktörlerin belirlenmesi, gereksiz aksiller diseksiyonu önleyip morbiditeyi azaltacaktır. Gereç ve Yöntem: Bu çalışmaya, 1998-2009 yılları arasında sentinel lenf nodu metastazı olup hastanemizde aksiller diseksiyon uygulanan 119 meme kanseri hastası dahil edildi. Primer tümör özellikleri yanı sıra mikroanatomik yerleşim, metastaz boyutu, metastatik tümör alanının total sentinel lenf nodu alanına oranı gibi sentinel lenf nodlarındaki tümör metastazlarının özellikleri değerlendirildi. İstatistiksel analiz için student t testi ve çok değişkenli lojistik regresyon kullanıldı.Bulgular: Hastaların ortalama yaşı 50.7 (28-80) olup, 43 hastanın (%36) invaziv duktal, 25 hastanın (%21) invaziv lobüler karsinom tanısı vardı. Hastaların çoğunda pT1 (%44) ya da pT2 (%54) tümör izlendi. Elli dört hastanın (%45) aksillasında non-sentinel lenf nodu metastazı izlenmedi. On altı hastanın (%13) sentinel lenf nodundaki metastatik odak subkapsüler yerleşimliydi. Tek yönlü analizde, metastatik tümör alanının total sentinel lenf nodu alanına oranı (p

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Cite This Article

HARMANCIOĞLU, Ö., KOÇDOR, M. A., BEKİŞ, R., SAYDAM, S., AKANSU, B., GÜRAY, M. D., AKIN, M. M., CANDA, T., SEVİNÇ, A. İ., ELLİDOKUZ, H. (2022). Sentinel nod pozitif meme karsinomunda non-sentinel lenf nodu tutulumunu öngören faktörler. Türk Patoloji Dergisi, Cilt: 27 - Sayı: 3, 189–195. https://ajindex.com/articles/640745

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