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Journals / Türk Patoloji Dergisi / 2014 / Cilt: 30 - Sayı: 2

Ameloblastom ve Odontojenik Kistlerde Caveolin-1 Ekspresyonu

Caveolin-1 Expression in Odontogenic Cysts and Ameloblastomas

Zohreh JAAFARI-ASHKAVANDI
Soheil PARDIS
Maryam ASADZADEH
Azadeh ANDISHEH-TADBIR
Ali DEHGHANI-NAZHVANI
Pages
94–99
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors.
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Key Findings & Data:Material and Method: In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic).
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Conclusion & Impact:The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.
🔬Design:Research Article
📍Scope:75 samples
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors. Material and Method: In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic). Results: Positive immunohistochemical reaction was found in 100% of odontogenic cysts and this was significantly more than both unicystic (65%) and solid (55%) ameloblastomas. Conclusion: The present study showed the expression of caveolin-1 in all odontogenic cysts and more than ameloblastomas. The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.

Özet

Amaç: Bu çalışmanın amacı, bir grup odontojenik kist ve tümörde caveolin-1 ekspresyonunu değerlendirmektir. Gereç ve Yöntem: Bu çalışmada, caveolin-1 ekspresyonu, 18 dentigeröz kist, 18 odontojenik keratosit, 3 ortokeratinize odontojenik kist, 2 kalsifiye odontojenik kist ve 34 ameloblastomu (solid ve unikistik) içeren 75 olguda immünohistokimyasal olarak değerlendirilmiştir. Bulgular: Odontojenik kistlerin % 100ünde pozitif immüno- histokimyasal reaksiyon saptanmıştır. Bu sonuç hem unikistik (% 65) hem de solid (% 55) ameloblastomada saptanandan anlamlı ölçüde yüksektir. Sonuç: Bu çalışma caveolin-1 ekspresyonunun, bütün odontojenik kistlerde ameloblastomalardan daha fazla olduğunu göstermiştir. Bulgular caveolin-1 yokluğunun odontojenik lezyonların agresivitesini arttırabileceğini ve ameloblastomaların diğer odontojenik lezyonlardan ayırt edilebilmesi için yararlı bir gösterge olabileceğini ortaya koymuştur.

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Cite This Article

JAAFARI-ASHKAVANDI, Z., PARDIS, S., ASADZADEH, M., ANDISHEH-TADBIR, A., DEHGHANI-NAZHVANI, A. (2022). Ameloblastom ve Odontojenik Kistlerde Caveolin-1 Ekspresyonu. Türk Patoloji Dergisi, Cilt: 30 - Sayı: 2, 94–99. https://ajindex.com/articles/640602

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References (14)

  1. Altini M, Coleman H, Doglioni C, Favia G, Maiorano E. Calretinin expression in ameloblastomas. Histopathology. 2000; 37:27-32
  2. Cairns L, Naidu A, Robinson CM, Sloan P, Wright JM, Hunter KD. CD56 (NCAM) expression in ameloblastomas and other odontogenic lesions. Histopathology. 2010;57:544-8
  3. Er N, Dağdeviren A, Taşman F, Zeybek D. Cell adhesion molecule and neurothelin expression in human ameloblastoma. J Oral Maxillogac Surg. 2001;23:900-3
  4. Kusafuka K, Hirobe K, Wato M, Tanaka A, Nakajima T. CD56 expression is associated with neuroectodermal differentiation in ameloblastomas: An immunohistochemical evaluation in comparison with odontogenic cystic lesions. Med Mol Morphol. 2011;44:79-85
  5. Shigeo K, Eisako I, Akira Y, Yoshinobu E, Norihiko O. Immunohistochemical characteristics of odontogenic carcinomas: Their use in diagnosting and elucidating histogenesis. Oral Medicine and Pathology. 2008;13:55-63
  6. Jaafari -Ashkavandi Z, Dehghani Najvani A, Andishe TadbirPardis S, Ranjbar MA, Ashraf MJ. MCM3 as a novel diagnostic marker in benign and malignant salivary gland tumors. Asian Pacific J Cancer Prev. 2013;14:3479-82
  7. Keisuke N, Hitoshi N, Hidetsugu T, Mehmet G, NaokiChong H, Toshiyuki K. Immunohistochemical characteristics of odontogenic neoplasms and their physiological counterparts. Journal of Hard Tissue Biology. 2008;17:79-90 8. Mistry D, Altini M, Coleman HG, Ali H, Maiorano E. The spatial and temporal expression of calretinin in developing rat molars (Rattus norvegicus). Arch Oral Biol. 2001;46:973-81
  8. Hung KF, Lin SC, Liu CJ, Chang CS, Chang KW, Kao SY. The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis. J Oral Pathol Med. 2003;32:461-7
  9. Lajoie P, Nabi RI. Lipid rafts, caveolae, and their endocytosis.Rev Cell Mol Biol. 2010;282:135-63
  10. Liu P, Rudick M, Anderson RG. Multiple functions of caveolin-1. J Biol Chem. 2002;277:41295-8
  11. Roberts AB, Wakefield LM. The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA. 2003;100: 8621–3
  12. Liu P, Li WP, Machleidt T, Anderson RG. Identificationcaveolin-1 in lipoprotein particles secreted by exocrine cells Cell Biol. 1999;1:369-75
  13. Li WP, Liu P, Pilcher BK, Anderson RG. Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasmmitochondria. J Cell Sci. 2001;114:1397-1408
  14. Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer and metastasis. Am