AI Summary & Key Takeaways
AI InsightThe Gleason score, localization and volume of the tumors are important for patient follow-up, treatment and prognosis.
📌 3 Key Takeaways
Abstract
Objective: Prostate cancer is the second most common cancer in men. Digital rectal examination, transrectal ultrasonography and serum prostatespecific antigen represents a diagnostic triad for the detection of prostatic carcinoma. About 50 years ago, Dr. Donald Gleason created a gradingsystem for prostate cancer based on its histologic patterns. Currently, this system maintains its validity with various changes. New updates weremade in 2005 and 2014 by the International Society of Urological Pathology. The goal of biopsies is to determine the Gleason score and prognosisin prostatectomy material. The aim of this study was to determine the concordance of the Gleason score, tumor volume and tumor lateralitybetween prostate needle biopsy and prostatectomy materials.Material and Method: The study was performed with 112 patients who had biopsy and prostatectomy materials. The Gleason grades of thetumors have been evaluated with the new grading system. Tumor volumes were calculated by the number of positive blocks while tumor lateralitywas evaluated as unilateral or bilateral. Statistical analysis was performed on the obtained data.Results: Gleason score, tumor volume and tumor laterality discordance between needle biopsy and prostatectomy materials was found to bestatistically significant. However, the concordance increased as the Gleason score and tumor volume increased.Conclusion: Digital examination, serum prostate specific antigen value and needle biopsy together are very sensitive for a prostate adenocarcinomadiagnosis. The Gleason score, localization and volume of the tumors are important for patient follow-up, treatment and prognosis.