AI Summary & Key Takeaways
AI InsightTheTPAM should be supported by the manual method to decrease the false positive rate.
📌 3 Key Takeaways
Abstract
Objective: To compare the diagnostic results of the ThinPrep manual method (TPMM) and ThinPrep automated method (TPAM) in liquid-basedcytology and present the advantages and disadvantages of both methods.Material and Method: A total of 1.500 randomized ThinPrep Pap tests that were screened manually and archived in 2015 were reviewed by ablinded researcher manually and by the ThinPrep automatic method.Results: There was a 83.3% increase in the detection of ASCUS (Atypical squamous cells of undetermined significance) with the TPAMcompared to the TPMM, and with respect to the reference results, the accuracy was higher for the TPAM than for the TPMM. We also noteda 33.3% increase in the rate of LSIL (Low grade squamous intraepithelial lesion) and 20% increase in the rate of HSIL (High grade squamousintraepithelial lesion) by the TPAM. Concordance was best between the TPAM and reference cytologic diagnoses. The sensitivity was higherfor the TPAM and the specificity was similar for both methods. The false positive rate was higher for the TPAM than the TPMM but the falsenegative rate was higher for the TPMM. We determined a 30% gain in screening time per smear by the TPAM. However, rejection of manysamples by the system, especially because of air bubbles, was a limitation of the TPAM.Conclusion: The TPAM has advantages over the TPMM as well as disadvantages such as limiting features and a high false positive rate. TheTPAM should be supported by the manual method to decrease the false positive rate.