Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

Elnur ALİZADE; Anıl AVCI; Ahmet GÜNER; Mehmet Mustafa TABAKCI; Regayip ZEHİR; Ahmet GÜLER; Servet İZCİ; Selçuk Pala

Journals / Koşuyolu Heart Journal / 2016 / Cilt: 19 - Sayı: 2

Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

Monositin HDL Kolesterole Oranının Kardiyak Sendrom X ve Sistemik İnflamasyon ile İlişkisi

Elnur ALİZADE

Anıl AVCI

Ahmet GÜNER

Mehmet Mustafa TABAKCI

Journal: Koşuyolu Heart Journal
Issue: 2016 · Cilt: 19 - Sayı: 2
Pages: 97–102
Publication Date: 2016-08-01
DOI: —

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AI Summary & Key Takeaways

AI Insight

⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In conclusion, our findings revealed that higher MHR levels were significantly and independently associated with the presence of CSX.

📌 3 Key Takeaways

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Objective & Hypothesis: Introduction: The aim of this study was to investigate an easily available inflammatory marker and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) in patients with cardiac syndrome X (CSX).

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Key Findings & Data:Patients and Methods: The study population included 100 patients of which 50 had CSX (CSX group) and 50 had normal coronary angiograms (control group).

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Conclusion & Impact:Conclusion: In conclusion, our findings revealed that higher MHR levels were significantly and independently associated with the presence of CSX.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Kardiyak sendrom X · monositin HDL kolesterole oranı · inflamatuvar göstergeler

Abstract

Introduction: The aim of this study was to investigate an easily available inflammatory marker and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) in patients with cardiac syndrome X (CSX). Patients and Methods: The study population included 100 patients of which 50 had CSX (CSX group) and 50 had normal coronary angiograms (control group). Results: Total white blood cell (WBC) count, monocyte count, neutrophil count, NLR, high-sensitivity C-reactive protein (hs-CRP), C-reactive protein (CRP) and MHR were higher in the CSX group (p< 0.05), whereas high-density lipoprotein cholesterol (HDL-C) level was significantly lower in the CSX group as compared with that in the control group (p< 0.05). In the correlation analysis, MHR revealed a significantly positive correlation with hs-CRP (r= 0.375, p< 0.001) and CRP (r= 0.403, p< 0.001). In the multivariate logistic regression analysis, MHR was independently associated with the presence of CSX (odds ratio: 1.250, 95% confidence interval [CI]: 1.240-1.461, p< 0.001). Using a cut-off level of 90.6, pre-procedural MHR predicted the presence of slow coronary flow (SCF) with a sensitivity of 78% and specificity of 70%. Conclusion: In conclusion, our findings revealed that higher MHR levels were significantly and independently associated with the presence of CSX.

Özet

Giriş: Bu çalışmanın amacı, kardiyak sendrom X (KSX) hastalarında monositin HDL kolesterole oranı (MHO)’nı ve kolay kullanılabilir inflamatuvar göstericileri araştırmaktır. Hastalar ve Yöntem: Çalışmaya 50’si KSX ve 50’si normal koroner arterlere sahip toplam 100 hasta dahil edilmiştir. Bulgular: Total beyaz küre sayısı, nötrofil sayısı, monosit sayısı, lenfosit sayısı, nötrofil/lenfosit oranı, C-reaktif protein, hsCRP ve MHO KSX grubunda artmıştır (p< 0.05), ancak HDL kolesterol CSX hastalarında kontrol grubuna göre azalmıştır (p< 0.05). Korelasyon analizinde MHO’nun hsCRP (r= 0.375, p< 0.001) ve CRP (r= 0.403, p< 0.001) ile pozitif yönde korelasyon olduğu gösterilmiştir. Multivariate logistic regresyon analizinde MHO’nun KSX hastalığını göstermede bağımsız bir gösterge olduğu bulundu [odds ratio: 1.250, 95% confidence interval (CI): 1.240-1.461, p< 0.001]. Sınır değeri 90.6 alırsak, MHO bu oran ile KSX hastalığının varlığını %78 duyarlılık ve %70 özgüllükle göstermektedir. Sonuç: Çalışmamızda MHO KSX hastalarını göstermede ciddi ve bağımsız bir gösterge olduğu gösterilmiştir.

Keywords

Kardiyak sendrom X monositin HDL kolesterole oranı inflamatuvar göstergeler Cardiac syndrome X monocyte-to-HDL cholesterol ratio inflammatory markers

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Cite This Article

ALİZADE, E., AVCI, A., GÜNER, A., TABAKCI, M. M., ZEHİR, R., GÜLER, A., İZCİ, S., Pala, S. (2016). Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation. Koşuyolu Heart Journal, Cilt: 19 - Sayı: 2, 97–102. https://ajindex.com/articles/63943

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References (13)

Kaski JC, Rosano GM, Collins P, Nihoyannopoulos P, Maseri A, Poole-Wilson PA. Cardiac syndrome X: clinical characteristics and left ventricular function. Long-term follow-up study. J Am Coll Cardiol 1995;25:807-14
Scholz M, Wegener K, Unverdorben M, Kleipzig H. Long-term outcome in patients with angina-like chest pain and normal coronary angiograms [in German]. Herz 2003; 28:413-20
Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 2004; 109:2518-23
Al Suwaıd J, Hıgano ST, Holmes Dr JR, Lerman A. Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography. Mayo Clin Proc 2001;76:813-22
Hurst T, Olson TH, Olson LE, Appleton CP. Cardiac syndrome X and endothelial dysfunction: new concepts in prognosis and treatment. Am J Med 2006;119:560-6
Luo C, Li Y, Liu D, Hu C, Du Z. The association of brachial flow-mediated dilatation and high-sensitivity C-reactive protein levels with Duke treadmill score in patients with suspected microvascular angina. Exp Clin Cardiol 2012;17:197-201
Recio-Mayoral A, Rimoldi OE, Camci PG, Kaski JC. Inflammation and microvascular dysfunction in cardiac syndrome X patients without conventional risk factors for coronary artery disease. JACC Cardiovasc Imaging 2013;6:660-7
Ancuta P, Wang J, Gabuzda D. CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1- expressing endothelial cells. J Leukoc Biol 2006;80:1156e1164
Hessler JR, Robertson AL, Chisolm GM. LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture. Atherosclerosis 1979;32:213e229
Li XP, Zhao SP, Zhang XY, Liu L, Gao M, Zhou QC. Protective effect of high density lipoprotein on endothelium-dependent vasodilatation. Int J Cardiol 2000;73:231e236
Kanbay M, Solak Y, Unal HU, Kurt YG, Gok M, Cetinkaya H, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 2014;46:1619e1625
Canpolat U, Aytemir K, Yorgun H, Şahiner L, Kaya EB, Çay S, et al. The role of preprocedural monocyte-to-high-density lipoprotein ratio in prediction of atrial fibrillation recurrence after cryoballoon-based catheter ablation. Europace 2015;pii:euu291
Canpolat U,