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Journals / Türk Onkoloji Dergisi / 2016 / Cilt: 31 - Sayı: 1

Effect of Radiotherapy Dose Rates on Early Intestinal Toxicity

Harun ÇELİK
Dilek ÜNAL
Arzu TAŞDEMİR
Serhat AYDOĞAN
Tuba Dilay ÜNAL
Hatice KARAMAN
Celalettin EROĞLU
Bünyamin KAPLAN
Pages
5–9
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Villus length was significantly decreased in the 300 MU/min group, compared to the other groups, and villus width was significantly increased in the control group, compared to the other groups.CONCLUSIONRT application with high dose may be less toxic for tissue with high risk for acute toxicity, such as that of the small intestine.

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Objective & Hypothesis:The aim of the present study was to investigate early histopathological changes in small intestinal tissue caused by radiotherapy (RT) applications with varying dose rates in rats.METHODSThirty rats were divided into 3 groups.
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Key Findings & Data:The first and second groups were irradiated at 300 MU/min and 600 MU/min, respectively.
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Conclusion & Impact:Villus length was significantly decreased in the 300 MU/min group, compared to the other groups, and villus width was significantly increased in the control group, compared to the other groups.CONCLUSIONRT application with high dose may be less toxic for tissue with high risk for acute toxicity, such as that of the small intestine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of the present study was to investigate early histopathological changes in small intestinal tissue caused by radiotherapy (RT) applications with varying dose rates in rats.METHODSThirty rats were divided into 3 groups. The first and second groups were irradiated at 300 MU/min and 600 MU/min, respectively. The third was a control group. On day 7 following RT application, small intestine tissue samples were obtained.RESULTSMucosal thickness was significantly lower in the 300 MU/min group, compared to the other groups, and thickness was significantly lower in the 600 MU/min group, compared to the control group. Villus length was significantly decreased in the 300 MU/min group, compared to the other groups, and villus width was significantly increased in the control group, compared to the other groups.CONCLUSIONRT application with high dose may be less toxic for tissue with high risk for acute toxicity, such as that of the small intestine.

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Cite This Article

ÇELİK, H., ÜNAL, D., TAŞDEMİR, A., AYDOĞAN, S., ÜNAL, T. D., KARAMAN, H., EROĞLU, C., KAPLAN, B. (2022). Effect of Radiotherapy Dose Rates on Early Intestinal Toxicity. Türk Onkoloji Dergisi, Cilt: 31 - Sayı: 1, 5–9. https://ajindex.com/articles/639304

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