Journals / Türk Onkoloji Dergisi / 2020 / Cilt: 35 - Sayı: 2

Radiotherapy in Patients with Trachea Tumours: A Retrospective Study and Literature Review

Pages
167–177
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The 5-year overall and diseasefree survival rates were 83% and 67%, respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE In this study, we aimed to evaluate our patients with tracheal tumours treated with primary or adjuvant radiotherapy (RT) and to review the current literature on the subject.
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Key Findings & Data:METHODS Between 1998 and 2017, eight patients underwent RT.
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Conclusion & Impact:The 5-year overall and diseasefree survival rates were 83% and 67%, respectively.
🔬Design:Review & Systematic Survey
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE In this study, we aimed to evaluate our patients with tracheal tumours treated with primary or adjuvant radiotherapy (RT) and to review the current literature on the subject. METHODS Between 1998 and 2017, eight patients underwent RT. Their median age was 37 years (15–53). The diagnosis was adenoid cystic carcinoma in five patients, squamous cell carcinoma in three patients and mucoepidermoid carcinoma in one patient. Resection type was R0 (1), R1 (4), R2 (1), and biopsy (2). The median tumour size was 2.6 cm (2–5). Median 59.4 Gy RT (32.4–66.6) was given, and weekly cisplatin was administered to four patients concomitantly. RESULTS With a median follow-up of 85 months (4–189), five patients were alive. The 5-year overall and diseasefree survival rates were 83% and 67%, respectively. There was no local recurrence in any patient. In one patient who had a complete response with curative chemo-RT, dilatation was performed five times in 10 years because tracheal stenosis developed at 60 months. CONCLUSION Trachea tumours are rare, and the primary treatment is surgery. Adjuvant RT is controversial in R0 cases. In unresectable cases, RT is the primary treatment modality. We believe that our treatment results will contribute to the literature on the subject.

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Cite This Article

SARIHAN, S., BAYRAM, A. S., MELEK, H., GEBİTEKİN, C. (2022). Radiotherapy in Patients with Trachea Tumours: A Retrospective Study and Literature Review. Türk Onkoloji Dergisi, Cilt: 35 - Sayı: 2, 167–177. https://ajindex.com/articles/639161

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References (14)

  1. Gomez DR, Fuller CD, Chennupati S, Thomas Jr CR. Mediastinal and Tracheal Cancer. In: Halperin EC, Wazer DE, Perez CA, Brady LW editors. Perez and Bradys Principles and Practice of Radiation Oncology. 6th edition, Philadelphia: LWW; 2013. p. 973–95
  2. Bhattacharyya N. Contemporary staging and prognosis for primary tracheal malignancies: a population-based analysis. Otolaryngol Head Neck Surg 2004;131(5):639–42
  3. Licht PB, Friis S, Pettersson G. Tracheal cancer in Denmark: a nationwide study. Eur J Cardiothorac Surg 2001;19(3):339–45
  4. Mallick S, Benson R, Giridhar P, Rajan Singh A, Rath GK. Demography, patterns of care and survival outcomes in patients with malignant tumors of trachea: A systematic review and individual patient data analysis of 733 patients. Lung Cancer 2019;132:87–93
  5. Grillo HC, Mathisen DJ. Primary tracheal tumors: Treatment and results. Ann Thorac Surg 1990;49(1):69–77
  6. Macchiarini P. Primary tracheal tumours. Lancet Oncol 2006;7(1):83–91
  7. Webb BD, Walsh GL, Roberts DB, Sturgis EM. Primary tracheal malignant neoplasms: The University of Texas MD Anderson Cancer Center Experience. J Am Coll Surg 2006;202(2):237–46
  8. He J, Shen J, Huang J, Dai C, Liang W, Ye M, et al. Prognosis of primary tracheal tumor: A populationbased analysis. J Surg Oncol 2017;115(8):1004–10
  9. Honings J, Gaissert HA, Verhagen AF, van Dijck JA, van der Heijden HF, van Die L, et al. Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data. Ann Surg Oncol 2009;16(2):246–53
  10. Gaissert HA, Grillo HC, Shadmehr MB, Wright CD, Gokhale M, Wain JC, et al. Long-term survival after resection of primary ACC and SCC of the trachea and carina. Ann Thorac Surg 2004;78(6):1889–96
  11. Yang KY, Chen YM, Huang MH, Perng RP. Revisit of primary malignant neoplasma of the trachea: clinical characteristics and survival analysis. Jpn J Clin Oncol 1997;27(5):305–9
  12. Regnard JF, Fourquier P, Levasseur P. Results and prognostic factors in resections of primary tracheal tumors: a multicenter retrospective study. The French Society of Cardiovascular Surgery. J Thorac Cardiovasc Surg 1996;111(4):808–13
  13. National Cancer Institue. DCTD Division of Cancer Treatment and Diagnosis. Available at: https://ctep. cancer.gov/. Accessed Feb 20, 2020
  14. Honings J, Gaissert HA, Weinberg AC, Mark EJ, Wright CD, Wain JC, et al. Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma. Eur J Cardiothorac