Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome

Cem DOĞAN; Onur TAŞAR; Zübeyde BAYRAM; Rezzan DENİZ ACAR; Murat ÇAP; Emrah ERDOĞAN; Cihangir KAYMAZ; Nihal ÖZDEMİR

Journals / Koşuyolu Heart Journal / 2019 / Cilt: 22 - Sayı: 2

Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome

Artmış Kalıntı Kolesterol Kan Düzeyleri İlk Defa Geçirilen Akut Koroner Sendrom ile İlişkilidir

Journal: Koşuyolu Heart Journal
Issue: 2019 · Cilt: 22 - Sayı: 2
Pages: 69–73
Publication Date: 2019-08-15
DOI: —

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AI Summary & Key Takeaways

AI Insight

⚡ TL;DR(Too Long; Didn't Read)

Further studies should be performed focusing on lowering remnant cholesterol levels apart from lowering LDL-C levels in patients with ACS.

📌 3 Key Takeaways

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Objective & Hypothesis: Introduction: This study aimed to investigate the association between remnant cholesterol and acute coronary syndrome (ACS) and its predictive value for acute coronary syndrome occurring for the first time.

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Key Findings & Data:Patients and Methods: We compared increasing concentrations of non-fasting remnant cholesterol aside from other lipid profile parameters to investigate this association in 226 patients with ACS for the first time and 192 elective coronary angiography patients with normal coronary arteries.

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Conclusion & Impact:Further studies should be performed focusing on lowering remnant cholesterol levels apart from lowering LDL-C levels in patients with ACS.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Akut koroner sendrom · kalıntı kolesterol · trigliseritten zengin lipoproteinler

Abstract

Introduction: This study aimed to investigate the association between remnant cholesterol and acute coronary syndrome (ACS) and its predictive value for acute coronary syndrome occurring for the first time. Patients and Methods: We compared increasing concentrations of non-fasting remnant cholesterol aside from other lipid profile parameters to investigate this association in 226 patients with ACS for the first time and 192 elective coronary angiography patients with normal coronary arteries. Results: Patients with ACS were mostly males and were younger than those in the control group; moreover, they had higher percentage of diabetes mellitus (for all p< 0.001). Glucose and white blood cell levels at admission were also higher in patients with ACS. Remnant cholesterol level (such as LDL-C) was statistically higher in the ACS group compared with those of the control group (p< 0.001). In the univariate and bivariate binary logistic regression analysis, high blood remnant cholesterol, high blood LDL-C, and low blood HDL-C levels had a predictive value for ACSs. Conclusion: This study demonstrated that remnant cholesterol levels (such as high blood LDL-C levels) are associated with increased risk of ACS for the first time. Further studies should be performed focusing on lowering remnant cholesterol levels apart from lowering LDL-C levels in patients with ACS.

Özet

Giriş: Açlık dışı kalıntı kolesterolün artması, artmış düşük dansiteli lipoprotein kolesterol (LDL-C) gibi iskemik kardiyovasküler hastalıklar için artmış risk ile ilişkilidir. Çalışmamızın amacı, ilk kez akut koroner sendrom (AKS) ile gelen hastalarda kalıntı kolesterol ve akut koroner sendromun arasındaki ilişkiyi araştırmaktır. Hastalar ve Yöntem: İlk kez akut koroner sendrom ile başvuran 226 hasta ve normal koroner arter olarak sonuçlanmış 192 elektif koroner anjiyografi hastasında, diğer lipit profili parametrelerinin yanı sıra, açlık dışı kalıntı kolesterolün artan konsantrasyonlarını karşılaştırdık. Bulgular: AKS hastaları kontrol grubu ile karşılaştırıldığında erkek cinsiyet fazla, daha genç ve daha fazla oranda diabetes mellitus mevcuttu (tümü için p< 0.001). AKS hastalarında glukoz ve beyaz kan hücresi düzeyleri de daha yüksekti. Kalıntı kolesterol, LDL-C değerine benzer şekilde, AKS grubunda istatistiksel olarak kontrol grubu ile karşılaştırıldığında daha yüksekti (p< 0.001). Tek değişkenli ve çok değişkenli ikili lojistik regresyon analizinde yüksek kan kalıntı kolesterolü, yüksek kan LDL-C değerleri ve düşük kan HDL-C değerleri ile akut koroner sendromlar arasında anlamlı bir ilişki mevcuttu. Sonuç: Çalışmamız, yüksek kan LDL-C seviyelerinde olduğu gibi artmış kalıntı kolesterol düzeylerinin artmış ilk kez yaşanılan AKS riski ile ilişkili olduğunu göstermiştir. AKS hastalarında LDL-C düzeylerinin düşürülmesinin yanı sıra kalıntı kolesterol düzeylerinin düşürülmesi üzerine daha fazla çalışma yapılmalı ve odaklanılmalıdır.

Keywords

Akut koroner sendrom kalıntı kolesterol trigliseritten zengin lipoproteinler Acute coronary syndrome remnant cholesterol triglyceride-rich lipoproteins

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Cite This Article

DOĞAN, C., TAŞAR, O., BAYRAM, Z., ACAR, R. D., ÇAP, M., ERDOĞAN, E., KAYMAZ, C., ÖZDEMİR, N. (2019). Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome. Koşuyolu Heart Journal, Cilt: 22 - Sayı: 2, 69–73. https://ajindex.com/articles/63850

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References (12)

Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. ESC Scientific Document Group. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J 2016;37:2999-3058
Ray KK, Cannon CP, Cairns R, Morrow DA, Ridker PM, Braunwald E. Prognostic utility of ApoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22. Arterioscler Thromb Vasc Biol 2009;29:424-30
Grundy SM, Cleeman JI, Merz CNB, Brewer HB, Clark LT, Hunninghake DB, et al. Coordinating Committee of the National Cholesterol Education Program. Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. J Am Coll Cardiol 2004;44:720-32
Havel RJ. Remnant lipoproteins as therapeutic targets. Curr Opin Lipidol 2000;11:615-20
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97
Miller M, Ginsberg HN, Schaefer E J. Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease. Am J Cardiol 2008;101:1003-8
Varbo A, Benn M, Tybjærg-Hansen A, Jørgensen AB, Frikke-Schmidt R, Nordestgaard BG. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol 2013;61:427-36
Nordestgaard BG, Benn M, Schnohr P, Tybjærg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007;298:299-308
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502
Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet 2014;384:626-35
Varbo A, Benn M, Nordestgaard BG. Remnant cholesterol as a cause of ischemic heart disease: evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment. Pharmacol Ther 2014;141:358-67
Shaikh M, Wootton R, Nordestgaard BG, Baskerville P, Lumley JS, La Ville AE, et al. Quantitative studies of transfer in vivo of low densit