Journals / Türk Patoloji Dergisi / 2012 / Cilt: 28 - Sayı: 2

Hatay yöresinde fetal otopsi bulgularının değerlendirilmesi: 274 olgu

Evaluation of fetal autopsy findings in the Hatay region: 274 cases

Pages
154–161
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to present the incidence of fetal anomalies in our region of Hatay, Turkey in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies.
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Key Findings & Data:Material and Method: This study was conducted on 274 fetuses from terminated pregnancies due to abnormal prenatal findings and intrauterine deaths from 2005 to September 2010.
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Conclusion & Impact:New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to present the incidence of fetal anomalies in our region of Hatay, Turkey in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. Material and Method: This study was conducted on 274 fetuses from terminated pregnancies due to abnormal prenatal findings and intrauterine deaths from 2005 to September 2010. Fetuses were evaluated through postmortem examination, external measurements, X-rays, Magnetic Resonance Images, Multislice Computerized Tomography and photographs. The autopsy was completed by the histological examination of each organ.Results: Autopsy was conducted on 274 fetuses. A fetal anomaly was detected in 160 (58.39%) cases. The central nervous system contained the most frequent structural defects (79 cases, 49.38%), followed by malformations in the musculoskeletal system in 36 cases (22.5%). The most frequent multiple system anomalies were central nervous system defect and bilateral adrenal agenesis, musculoskeletal system malformations and urinary system defects. Fetal autopsy provided additional findings in 43 cases (26.88%).Conclusion: Fetal autopsy is a very important procedure and an integral part of the general prenatal management. New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.

Özet

Amaç: Bölgemizdeki fetal anomali insidansını belirlemek, ülkemizdeki ve diğer ülkelerdeki istatistiksel verileri karşılaştırmak, fetal otopsi aracılığı ile prenatal tanının doğruluğunu belirlemek. Gereç ve Yöntem: 2005-2010 yılları arasında anormal prenatal bulgular veya intrauterin ölüm nedeni ile sonlandırılmış 274 olgu çalışmaya alındı. Fetuslar postmortem değerlendirildi. Dış vücut ölçümleri alındı, röntgen, manyetik rezonans, bilgisayarlı tomografi ve fotoğrafları çekildi. Otopsi organların histolojik incelemesi yapılarak tamamlandı.Bulgular: Toplam 274 olguya otopsi yapıldı. 160 olguda (%58,39) fetal anomali saptandı. Santral sinir sistemi anomalileri en sık yapısal defektti (79 olgu, %49,38). Bunu kas iskelet sistemi anomalileri izledi (36 olgu, %22,50). Çoklu sistem tutulumunda santral sinir sistemi anomalilerine bilateral adrenal agenezi ve kas iskelet sistemi anomalilerine de üriner sistem defektleri eşlik etmekteydi. Toplam 43 olguda (%26,88) otopsi sonucunda ek anomali saptandı.Sonuç: Fetal otopsi çok önemli bir işlemdir ve genel prenatal değerlendirmenin ayrılmaz bir parçasıdır. Bu yöntemle elde edilen yeni bulgular ebeveynlere gelecek gebeliklerdeki muhtemel riskler için çok önemli bilgiler verebilir.

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Cite This Article

YALDIZ, M., GÜNGÖREN, A., HAKVERDİ, S., GÜZELMANSUR, İ., TOPRAK, S., HAKERDİ, A. U. (2022). Hatay yöresinde fetal otopsi bulgularının değerlendirilmesi: 274 olgu. Türk Patoloji Dergisi, Cilt: 28 - Sayı: 2, 154–161. https://ajindex.com/articles/637514

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References (1)

  1. Ceylaner G, Ceylaner S, Günyeli I, Ekici E, Celasun B, Danışman N: Evaluation of 2407 fetuses in a Turkish population. Prenat Diagn 2007, 27: 800-807. [ PubMed ] 2) Sankar VH and Phadke SR: Clinical utility of fetal autopsy and comparison with prenatal ultrasound findings. J Perinatol 2006, 26: 224-229. [ PubMed ] 3) Boyd PA, Tondi F, Hicks NR, Chamberlain PF: Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study. Br Med J 2004, 17: 328(7432):137. [ PubMed ] 4) Amini H, Antonsson P, Papadogiannakis N, Ericson K, Pilo C, Eriksson L, Westgren M, Axelsson O:Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies. Acta Obstet Gynecol 2006, 85: 1208-1216. [ PubMed ] 5) http://www.tuik.gov.tr/jsp/duyuru/upload/vt/vt.htm. 6) Say B, Tunçbilek E, Balci S, Muluk Z, Gögüs T, Saraçlar M, Koçal C: Incidence of congenital malformation in a sample of the Turkish population. Hum Hered 1973, 23(5): 434-441. [ PubMed ] 7) Himmetoglu O, Tıraş MB, Gürsoy R, Karabacak O, Şahin I, Onan A: Incidence of congenital malformation in a Turkish population. Int J Gynaecol Obstet 1996, 55(2): 117-121. [ PubMed ] 8) Tunçbilek E, Boduroğlu K, Alikasifoğlu M: Results of the Turkish congenital malformation survey. Turk J Pediatr 1999, 41(3): 287-297. [ PubMed ] 9) Mandıracıoğlu A, Ulman I, Luleci E, Ulman C: The incidence and risk factors of neural tube defects in İzmir, Turkey: a nested case control study. Turk J Pediatr 2004, 46(3): 214-220. [ PubMed ] 10) Ceylaner S, Ceylaner G, Günyeli I, Ekici E, Tug M, Taner D, Ekerbicer H, Mollamahmutoğlu L, Danişman N:Postmortem evaluation of 220 prenataly diagnoses fetuses with neural tube defect detection of associated anomalies in a Turkish population. Prenat Diagn 2006, 26: 147–153. [ PubMed ] 11) Onrat ST, Seyman H, Konuk M: Incidence of neural tube defects in Afyonkarahisar, Western Turkey. Genet Mol Res 2009; 8(1): 154-61. [ PubMed ] 12) Sloan EP, Kirsh S, Mowbray M: Viewing the fetus following termination of pregnancy for fetal anomaly. JOGNN 2008, 37: 395-404. [ PubMed ] 13) Dickinson JE, Prime DK, Charles AK: The role of autopsy following pregnancy termination for fetal abnormality. ANZJOG 2007, 47: 445-449. [ PubMed ] 14) Pınar H, Tatevosyants N, Sınger DB: Central nervous system malformations in a perinatal/neonatal autopsy series. Pediatr Dev Pathol 1998, 1: 42-48. [ PubMed ] 15) Nielsen LA, Maroun LL, Broholm H, Laursen H, Graem N: Neural tube defect and associate