Journals / Türk Kolon ve Rektum Hastalıkları Dergisi / 2021 / Cilt: 31 - Sayı: 3

Early-Onset Colorectal Cancer in Younger Patients with a More Advanced Stage and Worse Postoperative Results: A Retrospective Review

Daha İleri Evre ve Daha Kötü Postoperatif Sonuçlara Sahip Genç Hastalarda Erken Başlangıçlı Kolorektal Kanser: Retrospektif Bir İnceleme

Pages
174–181
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Complications including the need for reoperation are more frequent in this group.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The incidence of colorectal tumors in young patients has been rising lately, and current investigations focus on the causes and prognosis in these patients.
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Key Findings & Data:Method: A retrospective analysis of patients undergoing surgery for colorectal adenocarcinoma during 2015-2020 in a single institution was performed.
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Conclusion & Impact:Complications including the need for reoperation are more frequent in this group.
🔬Design:Research Article
📍Scope:2015-2020 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The incidence of colorectal tumors in young patients has been rising lately, and current investigations focus on the causes and prognosis in these patients. The objective of this publication is to analyze the results of the surgical treatment and tumor stages in young patients and compare them to those in older individuals. Method: A retrospective analysis of patients undergoing surgery for colorectal adenocarcinoma during 2015-2020 in a single institution was performed. Patients were divided into two categories, early-onset colorectal cancer (EOCRC) (younger than 50 years old) and average-onset CRC (AOCRC) (those on age for CRC screening), focusing on disease stage and postoperative outcomes. Results: Two hundred and seven patients were included: 32 in the EOCRC group and 175 in the AOCRC group. The median age was 42.10 years [standard deviation (SD) =5.74] and 65.38 years (SD =7.19), respectively. Dyslipidemia was more prevalent in the AOCRC group. The EOCRC group had more tumors in the upper rectum (28.13% vs. 8%; p=0.001) and transverse colon (21.88% vs. 10.29%; p=0.06) and higher rates of complications (43.75% vs. 28%; p=0.07) and reoperations (18.75 vs. 7.43%; p=0.04). Moreover, major complications were more frequent in younger patients. The EOCRC group had significantly more stage IV tumors (18.75% vs. 5.13%; p=0.01), and 46.86% of patients in this group had an advanced disease at the time of surgery. Conclusion: Patients in the EOCRC group are diagnosed at more advanced stages and show differences in tumor location. Complications including the need for reoperation are more frequent in this group.

Özet

Amaç: Son zamanlarda genç hastalarda kolorektal tümör insidansı artmakta olup, güncel araştırmalar bunun nedenlerini ve prognozunu belirlemeye yöneliktir. Bu derlemenin amacı, genç hastalarda cerrahi tedavi sonuçlarını ve tümör evrelerini analiz etmek ve bunları yaşlı bireylerle karşılaştırmaktır. Yöntem: Bu derlemede, 2015-2020 yılları arasında tek bir kurumda kolorektal adenokarsinom ameliyatı geçiren hastaların retrospektif bir analizi yapıldı. Hastalar iki kategoriye ayrılarak hastalık evresine ve ameliyat sonrası sonuçlara odaklanıldı: Elli yaşından genç hastalardaki erken başlangıçlı kolorektal kanserler (EOCRC) ve kolorektal kanser taramasının yapıldığı yaştaki hastalarda ortaya çıkan ortalama başlangıçlı kolorektal kanserler (AOCRC). Bulgular: Otuz ikisi EOCRC grubunda olmak üzere 207 hasta dahil edildi. Ortanca yaş sırasıyla 42,10 [standart sapma (SS) =5,74] ve 65,38 (SS =7,19) idi. AOCRC grubunda dislipidemi daha yaygındı. EOCRC grubunda daha fazla üst rektum (%28,13’e karşı %8, p=0,001) ve transvers kolon (%21,88’e karşı %10,29, p=0,06) tümörleri vardı, komplikasyon oranları (%43,75’e karşı %28, p=0,07) ve yeniden operasyon oranları (18,75’e karşı %7,43, p=0,04) daha yüksekti. Ayrıca, majör komplikasyonlar genç hastalarda daha sıktı. EOCRC grubu önemli ölçüde daha fazla evre IV tümör ile ilişkili idi (%18,75’e karşı %5,13, p=0,01) ve bu hastaların %46,86’sında ameliyat sırasında ilerlemiş hastalık mevcuttu.

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Cite This Article

AVELLANEDA, N. L., VERACİERTO, F., HEMANDEZ, A., SANTİLLAN, M., ODDİ, R., CARRİE, A., SENDRA, P. O., LASA, J. (2022). Early-Onset Colorectal Cancer in Younger Patients with a More Advanced Stage and Worse Postoperative Results: A Retrospective Review. Türk Kolon ve Rektum Hastalıkları Dergisi, Cilt: 31 - Sayı: 3, 174–181. https://ajindex.com/articles/634526

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