Journals / Türkiye Parazitoloji Dergisi / 2005 / Cilt: 29 - Sayı: 3

Comparative analysis at the nucleotide level of the genes encoding the lactate dehydrogenase enzyme of Plasmodium vivax and Plasmodium falciparum

Plasmodium vivax ve Plasmodium falciparum'un laktat dehidrogenaz enzimini kodlayan genlerinin nükleotid düzeyinde karşılaştırmalı analizi

Pages
149–153
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that the identity between two sequences was 74.8%.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the nucleotide sequence of the enzyme lactate dehydrogenase from Plasmodium vivax has been compared to the same enzyme from another malaria parasite Plasmodium falciparum.
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Key Findings & Data:It was found that the identity between two sequences was 74.8%.
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Conclusion & Impact:This site will be targeted in the design of novel antimaiarials for Plasmodium vivax as has been for Plasmodium falciparum.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the nucleotide sequence of the enzyme lactate dehydrogenase from Plasmodium vivax has been compared to the same enzyme from another malaria parasite Plasmodium falciparum. It was found that the identity between two sequences was 74.8%. The percentage of the GC value was found to be higher in the Plasmodium vivax lactate dehydrogenase (46.6%) than in that of Plasmodium falciparum (33%). The nucleotide sequence that corresponds to the 5 amino acid insertion in Plasmodium lactate dehydrogenase is also present in Plasmodium vivax. This site will be targeted in the design of novel antimaiarials for Plasmodium vivax as has been for Plasmodium falciparum.

Özet

Bu çalışmada Plasmodium vivax'ın laktat dehidrogenaz enzimini kodlayan genin nükleotid dizisi diğer bir sıtma paraziti olan Plasmodium falciparum'un aynı enzimini kodlayan genin nükleotid dizisi ile karşılaştırılmıştır. İki dizi arasındaki benzerlik %74,8' dir. Plasmodium vivax laktat dehidrogenazının % GC değeri (%46,6) Plasmodium falciparum laktat dehidrogenazindan (%33) daha yüksektir. Plasmodial laktat dehidrogenazdaki 5 amino asit insersiyonuna karşılık gelen nükleotid dizisi aynı zamanda Plasmodium vivax'da da mevcuttur. Bu bölge Plasmodium falciparum''da olduğu gibi yeni antimalarial tasarımında hedef olacaktır.

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Cite This Article

AKBULUT, E., ÇELİK, V., BALIK, T. D. (2022). Comparative analysis at the nucleotide level of the genes encoding the lactate dehydrogenase enzyme of Plasmodium vivax and Plasmodium falciparum. Türkiye Parazitoloji Dergisi, Cilt: 29 - Sayı: 3, 149–153. https://ajindex.com/articles/630818

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References (1)

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