Journals / Türkiye Parazitoloji Dergisi / 2017 / Cilt: 41 - Sayı: 4

Oxidative Status and Lipid Profile among Dogs at Different Stages of Visceral Leishmaniasis

Visseral Leishmaniasis’in Farklı Evrelerindeki Köpeklerde Oksidatif Durum ve Lipid Profili

Pages
183–187
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Compared to the control dogs, significant increases in the TOS and the LDL level and decreases in PON-1 activity and the HDL level were determined among the dogs at all stages of VL (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The purpose of the study was to investigate the oxidative status and lipid profile among dogs at different stages of visceral leishmaniasis (VL).
📊
Key Findings & Data:Methods: Dogs with VL were divided into four groups according to the classification reported by the Leishvet group: stage I (n=9), stage II (n=11), stage III (n=6), and stage IV (n=6); these dogs were compared to healthy control dogs (n=14).
💡
Conclusion & Impact:Results: Compared to the control dogs, significant increases in the TOS and the LDL level and decreases in PON-1 activity and the HDL level were determined among the dogs at all stages of VL (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of the study was to investigate the oxidative status and lipid profile among dogs at different stages of visceral leishmaniasis (VL). Methods: Dogs with VL were divided into four groups according to the classification reported by the Leishvet group: stage I (n=9), stage II (n=11), stage III (n=6), and stage IV (n=6); these dogs were compared to healthy control dogs (n=14). The lipid profile [high-density lipo- protein (HDL), low-density lipoprotein (LDL), cholesterol, and triglyceride levels) and oxidative status [total antioxidant capacity (TAC), total oxidant status (TOS), and paraoxonase-1 (PON-1) activity] were evaluated. Results: Compared to the control dogs, significant increases in the TOS and the LDL level and decreases in PON-1 activity and the HDL level were determined among the dogs at all stages of VL (p

Özet

Amaç: Bu çalışmada Visseral Leishmaniasis’in (VL) farklı evrelerindeki köpeklerde oksidatif durum ve lipid profilinin araştırılması amaçlanmıştır.Yöntemler: Çalışmada VL’li 32, klinik, hematolojik ve biyokimyasal bulgulara göre sağlıklı 14 olmak üzere toplam 46 köpek kullanılmıştır. VL’liköpekler Leishvet grubunun sınıflamasına göre evre I (n=9), evre II (n=11), evre III (n=6), evre IV (n=6) olarak dört gruba ayrılmış ve sağlıklıkontrol grubu (n=14) ile karşılaştırılmıştır. Hayvanlarda serum lipid profili değerlendirmesi adına yüksek yoğunluklu lipoprotein (HDL), düşükyoğunluklu lipoprotein (LDL), kolesterol ve trigliserit, oksidatif durum analizi için ise toplam antioksidan kapasite (TAK), toplam oksidan seviye(TOS), paraoksonaz-1 (PON-1) değerleri incelenmiştir.Bulgular: VL’li köpeklerde, hastalığın tüm evrelerinde, sağlıklı gruptaki köpeklere kıyasla TOS değeri ve LDL konsantrasyonunda artış, PON-1aktivitesi ve HDL konsantrasyonunda ise azalma belirlenmiştir (p

🔖

Cite This Article

GÜLTEKİN, M., BALIKÇI, C., PAŞA, S., AŞICI, G. S. E., GÜLTEKİN, G., URAL, K. (2022). Oxidative Status and Lipid Profile among Dogs at Different Stages of Visceral Leishmaniasis. Türkiye Parazitoloji Dergisi, Cilt: 41 - Sayı: 4, 183–187. https://ajindex.com/articles/630149

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (3)

  1. Otranto D, Dantas-Torres F, Breitschwerdt EB. Managing canine vector-borne diseases of zoonotic concern: part one. Trends Parasitol 2009; 25: 157-63. [CrossRef] Solano-Gallego L, Miró G, Koutinas A, Cardoso L, Pennisi MG, Fer- rer L, et al. LeishVet guidelines for the practical management of canine leishmaniosis. Parasit Vectors 2011; 4: 86. [CrossRef] Heidarpour M, Soltani S, Mohri M, Khoshnegah J. Canine visceral leishmaniasis: Relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res 2012; 111: 1491-6. [CrossRef] Almeida BFM, Narciso LG, Melo LM, Preve PP, Bosco AM, Lima VMF, et al. Leishmaniasis causes oxidative stress and alteration of oxidati- ve metabolism and viability of neutrophils in dogs. Vet J 2013; 198: 599-605. [CrossRef] Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinl Biochem 2004; 37: 112-9. [CrossRef] Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38: 1103-11. [CrossRef] Bakirci S, Bilgiç HB, Köse O, Aksulu A, Hacılarlıoğlu S, Erdoğan H, et al. Molecular and seroprevalence of canine visceral leishmania- sis in West Anatolia, Turkey. Turk J Vet Anim Sci 2016; 40: 637-44. [CrossRef] Balcıoğlu İC, Ertabaklar H, Paşa S, Özbel Y, Özensoy TS. Antalya ili ve ilçelerindeki dört köpek barınağında leishmaniasis seroprevalan- sının araştırılması. Türkiye Parazitol Derg 2009; 33: 4-7.
  2. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84. [CrossRef] Bildik A, Kargin F, Seryek K, Pasa S, Özensoy S. Oxidative stress and non-enzymatic antioxidative status in dogs with visceral Leishmaniasis. Res Vet Sci 2004; 77: 63-6. [CrossRef] Paltrinieri S, Solano-Gallego L, Fondati A, Lubas G, Gradoni L, Cas- tagnaro M, et al. Guidelines for diagnosis and clinical classification of leishmaniasis in dogs. J Am Vet Med Assoc 2010; 236: 1184-91. [CrossRef] Lamont J, Campbell J, FitzGerald P. Measurement of individual vs total antioxidants. Clin Chem 1997; 43: 852-4.
  3. Elkiran ET, Mar N, Aygen B, Gursu F, Karaoglu A, Koca S. Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population. BMC Cancer 2007; 7: 48. [CrossRef] Rossi G, Ibba F, Meazzi S, Giordano A, Paltrinieri S. Paraoxonase activity as a tool for clinical monitorin