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Journals / Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi / 2012 / Cilt: 58 - Sayı: 3

Ailesel akdeniz ateşli hastalarda kolinesteraz, adenozin deaminaz ve miyeloperoksidaz aktiviteleri

Activities of cholinesterases, adenosine deaminase and myeloperoxidase in patients with familial mediterrenean Fever

Ramazan ŞEKEROĞLU
Halil ÖZKOL
Sıddık KESKİN
İbrahim TEKEOĞLU
Levent EDİZ
Pages
184–188
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: In the current study, while ADA and MPO activities increased, AChE decreased significantly in both whole blood and serum in FMF-AP group, BChE decreased in only whole blood in this group compared with FMF-AFP and HC groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to determine Acetylcholinesterase (AChE), Butyrilcholinesterase (BChE), Adenosine Deaminase (ADA) and Myeloperoxidase (MPO) activities in patients with Familial Mediterranean Fever (FMF) during attacks and attack-free periods.
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Key Findings & Data:Materials and Methods: The subjects were divided into 3 groups: Group 1.
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Conclusion & Impact:Results: In the current study, while ADA and MPO activities increased, AChE decreased significantly in both whole blood and serum in FMF-AP group, BChE decreased in only whole blood in this group compared with FMF-AFP and HC groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to determine Acetylcholinesterase (AChE), Butyrilcholinesterase (BChE), Adenosine Deaminase (ADA) and Myeloperoxidase (MPO) activities in patients with Familial Mediterranean Fever (FMF) during attacks and attack-free periods. Although an inflammatory process is the main pathology in FMF, the activities of AChE, BChE and MPO which might be affected by inflammation has not yet been assessed in FMF. Materials and Methods: The subjects were divided into 3 groups: Group 1. FMF patients in acute attack period (FMF-AP); Group 2. FMF patients in attack-free period (FMF-AFP); Group 3. Healthy Control subjects (HC). The first two groups consisted of 41 and 35 patients, respectively. Thirty individuals without a history of other potential health problems constituted the healthy control (HC) group. We measured the activities of MPO, ADA, AChE and BChE in whole blood and serum of the study groups. Acute phase reactants (AFP) were also evaluated. Results: In the current study, while ADA and MPO activities increased, AChE decreased significantly in both whole blood and serum in FMF-AP group, BChE decreased in only whole blood in this group compared with FMF-AFP and HC groups (p

Özet

Amaç: Bu çalışmanın amacı Ailesel Akdeniz Ateşli (AAA) hastalarda atak ve atak olmayan dönemlerde Asetilkolinesteraz (AChE), Bütirilkolinesteraz (BChE), Adenozin Deaminaz (ADA) ve Miyeloperoksidaz (MPO) aktivitelerini belirlemek idi. İnflamatuvar süreç AAA‘da başlıca patoloji olmasına rağmen, inflamasyon tarafından etkilenebilen AChE, BChE ve MPO aktiviteleri AAA‘da henüz değerlendirilmemiştir. Gereç ve Yöntem: Olgular 3 gruba bölündüler. Grup 1. Akut atak dönemindeki AAA hastaları (AAA-AD); Grup 2. Atak olmayan dönemdeki AAA hastaları (AAA-AOD); Grup 3. Sağlıklı kontrol grubu (SK). İlk iki grup sırasıyla 41 ve 35 hastadan oluşmaktaydı. Potansiyel olarak herhangi bir sağlık problemi olmayan 30 kişi SK grubunu oluşturdu. Biz çalışma gruplarının tam kan ve serumlarında AChE, BChE, ADA ve MPO aktivitelerini ölçtük. Akut faz reaktanları da ayrıca değerlendirildi.. Bulgular: Bu çalışmada, AAA-AD grubunda, AAA-AOD ve SK grupları ile kıyaslandığında, hem tam kan hem de serum ADA, MPO aktiviteleri anlamlı derecede artmış, AChE düşmüşken, BChE bu grubun yalnızca tam kanlarında düşüktü (p

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Cite This Article

ŞEKEROĞLU, R., ÖZKOL, H., KESKİN, S., TEKEOĞLU, İ., EDİZ, L. (2022). Ailesel akdeniz ateşli hastalarda kolinesteraz, adenozin deaminaz ve miyeloperoksidaz aktiviteleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 58 - Sayı: 3, 184–188. https://ajindex.com/articles/628937

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