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Journals / Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi / 2012 / Cilt: 58 - Sayı: 4

Romatoid artritli hastalarda serum anti-cyclic citrullinated peptid antikor düzeyleri ve hastalık aktivitesi arasındaki ilişki

The relationship between serum levels of anti-cyclic citrullinated peptide antibodies and disease activity in patients with rheumatoid arthritis

Köksal DEVECİ
Alev GÜRGAN
Korhan Barış BAYRAM
Hikmet KOÇYİĞİT
Hülya DEVECİ
Pages
267–271
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Inlogistic regression analysis of multiple parameters, higher DAS-28 scoresand RF positivity were associated with 5.95 and 5.4 times greater risk ofbeing anti-CCP positive, respectively.Conclusion: Anti-CCP can be used in the diagnosis of patients withseronegative RA and also may be useful for reflecting disease activity

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Although there is an opinion that anti-cyclic citrullinated peptideantibody (anti-CCP) is a reliable diagnostic and prognostic indicator inrheumatoid arthritis (RA), its association with disease activity and severity isuncertain.
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Key Findings & Data:This study has been planned to determine the relationship betweenanti-CCP antibody levels and the disease activity in patients with RA.Materials and Methods: A total of 48 patients, who have been diagnosedwith RA, were included in the study.
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Conclusion & Impact:Inlogistic regression analysis of multiple parameters, higher DAS-28 scoresand RF positivity were associated with 5.95 and 5.4 times greater risk ofbeing anti-CCP positive, respectively.Conclusion: Anti-CCP can be used in the diagnosis of patients withseronegative RA and also may be useful for reflecting disease activity
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Although there is an opinion that anti-cyclic citrullinated peptideantibody (anti-CCP) is a reliable diagnostic and prognostic indicator inrheumatoid arthritis (RA), its association with disease activity and severity isuncertain. This study has been planned to determine the relationship betweenanti-CCP antibody levels and the disease activity in patients with RA.Materials and Methods: A total of 48 patients, who have been diagnosedwith RA, were included in the study. After physical examination, all patientswere evaluated with clinical and laboratory parameters. The clinicalsymptoms were assessed using visual analog scale (VAS), disease activityscore (DAS-28) and Health Assessment Questionnaire (HAQ). Rheumatoidfactor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),thrombocyte, leukocyte, hemoglobin and anti-CCP levels wereinvestigated.Results: The anti-CCP results were positive in 33 patients (68.7%) andnegative in 15 patients (31.3%). Anti-CCP was positive in 30.4% of RF-negative patients. A significant difference was observed in average RFlevels when the anti-CCP positive and negative patients were compared,however, there was no significance between other parameters. Inlogistic regression analysis of multiple parameters, higher DAS-28 scoresand RF positivity were associated with 5.95 and 5.4 times greater risk ofbeing anti-CCP positive, respectively.Conclusion: Anti-CCP can be used in the diagnosis of patients withseronegative RA and also may be useful for reflecting disease activity

Özet

Amaç: Anti-cyclic citrullinated peptide (anti-CCP) antikorunun romatoid artritde güvenilir tanısal ve prognostik bir gösterge olduğu düşüncesinerağmen hastalık aktivitesi ve şiddeti ile ilişkisi belirsizdir. Bu çalışma, romatoid artrit hastalarındaki anti-CCP antikor düzeylerinin hastalıkaktivitesi ile olan ilişkisini saptamak amacı ile planlandı. Gereç ve Yöntem: Çalışmaya RA tanısı almış olan toplam 48 hasta alındı.Hastalar fizik muayene sonrasında klinik ve laboratuvar parametreleriaçısından değerlendirildiler. Klinik bulgular görsel analog skala (GAS),hastalık aktivite skoru (DAS 28) ve Health Assessment Questionnaire (HAQ)ile değerlendirildi. Laboratuvar incelemesinde romatoid faktör (RF), eritrosit sedimentasyon hızı (ESH), C-reaktif protein (CRP), trombosit, lökosit, hemoglobin ve anti-CCP düzeylerine bakıldı. Bulgular: Anti-CCP sonuçları 33 hastada (%68,7) pozitif, 15 hastada (%31,3) negatif bulundu. RF negatif hastaların %30,4’ de anti-CCP pozitifbulundu. Anti-CCP pozitif ve negatif hastalar karşılaştırıldığında; ortalamaRF düzeyleri arasında anlamlı fark saptanırken, diğer parametreler arasındaanlamlı bir fark saptanmadı. Parametrelerin çoklu logistik regresyon analizinde, yüksek DAS-28 skoru ve RF pozitifliği, anti-CCP pozitifliği ilesırasıyla 5,95 ve 5,4 kat yüksek risk ile ilişkiliydi.Sonuç: Anti-CCP seronegatif RA’lı hastalarda RA teşhisini koymadakullanılabilir. Ayrıca, anti-CCP antikorları hastalık aktivitesini yansıtmadafaydalı olabilir.

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Cite This Article

DEVECİ, K., GÜRGAN, A., BAYRAM, K. B., KOÇYİĞİT, H., DEVECİ, H. (2022). Romatoid artritli hastalarda serum anti-cyclic citrullinated peptid antikor düzeyleri ve hastalık aktivitesi arasındaki ilişki. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 58 - Sayı: 4, 267–271. https://ajindex.com/articles/628925

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