SavedAdd your journal

Journals / Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi / 2016 / Cilt: 62 - Sayı: 2

Comparison of the effects of zoledronic acid and exercise on bone mineral density and biomechanics in rats with induced osteoporosis

Osteoporoz oluşturulan sıçanlarda zoledronik asit ve egzersizin kemik mineral yoğunluğu ve biyomekaniği üzerine etkilerinin karşılaştırılması

Murat GÜRGER
Arif GÜLKESEN
Mustafa ULAŞ
Gürkan AKGÖL
Remzi ATILGAN
Pages
156–161
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The maximum strain values of the exercise group were significantly higher than the zoledronic acid group and ovariectomy group (p< 0.05).Conclusion: Our study results show that exercise is as effective as the zoledronic acid therapy in the treatment and prevention of osteoporosis

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: This study aims to compare the effects of zoledronic acid and exercise on the bone mineral density (BMD) and biomechanics in rats with induced osteoporosis.Materials and methods: Thirty-two three-month-old female Wistar albino rats were enrolled in this study.
📊
Key Findings & Data:In the control group (n=8), only skin incision was performed.
💡
Conclusion & Impact:The maximum strain values of the exercise group were significantly higher than the zoledronic acid group and ovariectomy group (p< 0.05).Conclusion: Our study results show that exercise is as effective as the zoledronic acid therapy in the treatment and prevention of osteoporosis
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to compare the effects of zoledronic acid and exercise on the bone mineral density (BMD) and biomechanics in rats with induced osteoporosis.Materials and methods: Thirty-two three-month-old female Wistar albino rats were enrolled in this study. In the control group (n=8), only skin incision was performed. Bone mineral density was measured in the ovariectomized rats after two months. The rats with osteopenia were randomly divided into three groups. The first group (n=8) received single dose 0.1 mg/kg intravenous zoledronic acid, while the second group (n=8) underwent treadmill exercise test. The third group (n=8) received no medication or exercise. All rats were sacrificed at the end of week 12. The BMD of the right femurs was measured. The three-point bending test was performed on the left femurs.Results: The mean BMD values 12 weeks after surgical menopause was significantly higher in the control group than the other groups (p 0.05). The mean maximum stress values of the samples from the control group were significantly higher than the other groups (p< 0.05). The mean maximum strain value in the control group was higher than the zoledronic acid group and ovariectomy group (p< 0.05). Ovariectomy group had a lower biomechanical strength compared to the other groups. The maximum strain values of the exercise group were significantly higher than the zoledronic acid group and ovariectomy group (p< 0.05).Conclusion: Our study results show that exercise is as effective as the zoledronic acid therapy in the treatment and prevention of osteoporosis

Özet

Amaç: Bu çalışmada osteoporoz oluşturulan sıçanlarda zoledronik asit ve egzersizin kemik mineral yoğunluğu (KMY) ve biyomekaniği üzerine olan etkileri karşılaştırıldı.Gereç ve yöntemler: Çalışmaya 32 adet üç aylık dişi Wistar albino sıçan alındı. Kontrol grubuna (n=8) yalnızca cilt insizyonu yapıldı. Overektomize edilen sıçanlara iki ay sonra KMY ölçümü yapıldı. Osteopeni saptanan sıçanlar rastgele üç gruba ayrıldı. Birinci gruba (n=8) tek doz 0.1 mg/kg intravenöz zoledronik asit, ikinci gruba (n=8) treadmill egzersiz testi uygulandı. Üçüncü gruba ise (n=8), ilaç ve egzersiz uygulanmadı. On iki hafta sonunda sıçanların tümü sakrifiye edildi. Sağ femurların KMY ölçümü yapıldı. Sol femurlara ise üç nokta eğme testi yapıldı.Bulgular: Cerrahi menopozdan 12 hafta sonra ortalama KMY değerleri, diğer gruplara kıyasla, kontrol grubunda anlamlı düzeyde daha yüksekti (p 0.05). Kontrol grubundaki örneklerin ortalama maksimum stres değerleri, diğer gruplara kıyasla, anlamlı düzeyde daha yüksekti (p< 0.05). Kontrol grubundaki ortalama maksimum gerilme değeri, zoledronik asit grubu ve overektomi grubuna kıyasla, daha yüksekti (p< 0.05). Overektomi grubu, diğer gruplara kıyasla, daha zayıf biyomekanik dayanıma sahipti. Egzersiz grubunun maksimum gerilme değerleri, zoledronik asit grubu ve overektomi gruplarına kıyasla, anlamlı düzeyde daha yüksek bulundu (p< 0.05).Sonuç: Çalışma sonuçlarımız, osteoporozun tedavisinde ve önlenmesinde egzersizin zoledronik asit tedavisi kadar etkili olduğunu göstermektedir

🔖

Cite This Article

GÜRGER, M., GÜLKESEN, A., ULAŞ, M., AKGÖL, G., ATILGAN, R. (2022). Comparison of the effects of zoledronic acid and exercise on bone mineral density and biomechanics in rats with induced osteoporosis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 62 - Sayı: 2, 156–161. https://ajindex.com/articles/628677

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Nelson HD, Helfand M, Woolf SH, Allan JD. Screening for postmenopausal osteoporosis: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2002;137:529-41
  2. Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser 2003;916:1-149
  3. Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK. Bone loss and bone size after menopause. N Engl J Med 2003;349:327-34
  4. Seeman E. Invited Review: Pathogenesis of osteoporosis. J Appl Physiol (1985) 2003;95:2142-51
  5. Beck BR, Snow CM. Bone health across the lifespan-- exercising our options. Exerc Sport Sci Rev 2003;31:117-22
  6. Wallace BA, Cumming RG. Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women. Calcif Tissue Int 2000;67:10-8
  7. Warden SJ, Fuchs RK, Turner CH. Steps for targeting exercise towards the skeleton to increase bone strength. Eura Medicophys 2004;40:223-32
  8. Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP, et al. Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 2004;350:1189-99
  9. Harris ST. Bisphosphonates for the treatment of postmenopausal osteoporosis: clinical studies of etidronate and alendronate. Osteoporos Int 2001;12:11-6
  10. Fuchs RK, Shea M, Durski SL, Winters-Stone KM, Widrick J, Snow CM. Individual and combined effects of exercise and alendronate on bone mass and strength in ovariectomized rats. Bone 2007;41:290-6
  11. Robling AG, Hinant FM, Burr DB, Turner CH. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J Bone Miner Res 2002;17:1545-54
  12. Robling AG, Burr DB, Turner CH. Skeletal loading in animals. J Musculoskelet Neuronal Interact 2001;1:249-62
  13. Sugiyama T, Price JS, Lanyon LE. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 2010;46:314-21
  14. Rogers MJ, Crockett JC, Coxon FP, Mönkkönen J. Biochemical and molecular mechanisms of action of bisphosphonates. Bone 2011;49:34-41
  15. Cheer SM, Noble S. Zoledronic acid. Drugs 2001;61:799-805
  16. Boonen S, Black DM, Colón-Emeric CS, Eastell R, Magaziner JS, Eriksen EF, et al. Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older. J Am Geriatr Soc 2010;58:292