Both Ovx groups received treatment through gastric gavagefor 56 days.Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model.Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to threegroups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), andovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS).
📊
Key Findings & Data:This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model.Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to threegroups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), andovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS).
💡
Conclusion & Impact:Both Ovx groups received treatment through gastric gavagefor 56 days.Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p
🔬Design:Modeling & Simulation
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters
Abstract
This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model.Materials and methods: Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to threegroups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), andovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavagefor 56 days.Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p
🔖
Cite This Article
KÜRKÇÜ, M., OĞUZ, Ö., DERE, F., ÖZŞAHİN, E. T., ÇAM, B., SOAMES, R., EVRÜKE, C. (2022). The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 63 - Sayı: 2, 165–173. https://ajindex.com/articles/628584
Clinical practice guidelines for the diagnosis and management of osteoporosis. Scientific Advisory Board, Osteoporosis Society of Canada. CMAJ 1996;155:1113-33
Pérez-López FR. Postmenopausal osteoporosis and alendronate. Maturitas 2004;48:179-92
Grynpas MD, Lundon K. Bone quality in animal models of osteoporosis. Drug Development Research 2000;49:146-58
Libouban H, Moreau MF, Legrand E, Audran M, Baslé MF, Chappard D. Comparison of histomorphometric descriptors of bone architecture with dual-energy X-ray absorptiometry for assessing bone loss in the orchidectomized rat. Osteoporos Int 2002;13:422-8
Stepan JJ, Alenfeld F, Boivin G, Feyen JHM, Lakatos P. Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis. Endocrine Regulations 2003;37:227-40
Rehman MT, Hoyland JA, Denton J, Freemont AJ. Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis. J Clin Pathol 1995;48:229-35
Kharode YP, Sharp MC, Bodine PV. Utility of the ovariectomized rat as a model for human osteoporosis in drug discovery. Methods Mol Biol 2008;455:111-24
Eastell R, Hannon RA. Biomarkers of bone health and osteoporosis risk. Proc Nutr Soc 2008;67:157-62. 9. da Paz LH, de Falco V, Teng NC, dos Reis LM, Pereira RM, Jorgetti V. Effect of 17beta-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats. Braz J Med Biol Res 2001;34:1015-22
Fox J, Miller MA, Newman MK, Metcalfe AF, Turner CH, Recker RR, et al. Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength. Calcif Tissue Int 2006;79:262-72
Cao Y, Mori S, Mashiba T, Westmore MS, Ma L, Sato M, et al. Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res 2002;17:2237-46
Ito M, Azuma Y, Takagi H, Kamimura T, Komoriya K, Ohta T, et al. Preventive effects of sequential treatment with alendronate and 1 alpha-hydroxyvitamin D3 on bone mass and strength in ovariectomized rats. Bone 2003;33:90-9
Delmas PD, Schlemmer A, Gineyts E, Riis B, Christiansen C. Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J Bone Miner Res 1991;6:639-44