Journals / Türkiye Çocuk Hastalıkları Dergisi / 2009 / Cilt: 3 - Sayı: 2

A CASE REPORT: CUSHING’S SYNDROME SECONDARY TO TOPICAL CORTICOSTEROIDS

Olgu Sunumu: Topikal Steroid Kullanımına İkincil Cushing Sendromu

Pages
48–52
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The common communication tools should be used for this purpase, because the number of the similar case reports are increasing from Turkey are too many

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The use of topical glucocorticoids is common in chronic dermatosis.
📊
Key Findings & Data:We present here, a 48 days-old female baby who has iatrogenic Cushing’s syndrome secondary to the use of potent topical steroid.
💡
Conclusion & Impact:The common communication tools should be used for this purpase, because the number of the similar case reports are increasing from Turkey are too many
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İatrojenik Cushing sendromu · topikal steroid · Iatrogenic Cushing’s syndrome

Abstract

The use of topical glucocorticoids is common in chronic dermatosis. After topikal application, glucocorticoids are absorbed from skin and pas sistemic circulation. This may cause hypothalamushypophysis-adrenal axis suppression and Cushing’s syndrome. We present here, a 48 days-old female baby who has iatrogenic Cushing’s syndrome secondary to the use of potent topical steroid. Upon this case, we discussed the effects of topical steroids on adrenal axis and other advers effects. Detailed information should be given to pharmacists, parent an deven to physicians about the possible unwanted side effects of topical steroid use. The common communication tools should be used for this purpase, because the number of the similar case reports are increasing from Turkey are too many

Özet

Kronik dermatozlarda topikal steroidlerin kullanımı yaygındır. Topikal uygulama sonrası glukokortikoidlerin bir kısmı ciltten emilerek, sistemik dolaşıma geçebilir. Bunun sonucunda kullanılan topikal glukokortikoidin etkinliğine ve uygulanma süresine bağlı olarak iatrojenik Cushing sendromu gelişebilir ve hipotalamus-hipofiz-adrenal aksın baskılanmasına neden olabilirler. Burada güçlü topikal steroid kullanımına bağlı iyatrojenik Cushing sendromu gelişen 48 günlük bir kız bebek sunuldu. Bu olgu nedeni ile , topikal steroidlerin adrenal aks üzerine ve diğer olası yan etkilerini tartıştık. Topikal steroidlerin doğru kullanımı ve dikkatli kullanılmadığı takdirle olası yan etkileri konusunda eczacılar ve aileler, hatta doktorlar bilgilendirilmelidir. Gerekirse yaygın iletişim araçları bunun için kullanılmalıdır. Çünkü Türkiye’den benzer olgu sunumları oldukça fazladır.

🔖

Cite This Article

TAKÇI, Ş., ARI, M. E., TÜFEKÇİ, B. S., NAZLIER, K., ÇETİNKAYA, S. (2022). A CASE REPORT: CUSHING’S SYNDROME SECONDARY TO TOPICAL CORTICOSTEROIDS. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 3 - Sayı: 2, 48–52. https://ajindex.com/articles/627757

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Akan T. Topikal kortikosteroidlerin kullanımı.Katkı Pediatri Der- gisi 2000;21:599-604.
  2. Halverstam CP, Vachharajani A, Mallory SB. Cushing Syndrome from percutaneous absorbtion of 1% hydrocortisone ointment in Netherton Syndrome. Pediatr Dermatol 2007;24:42-45.
  3. Siklar Z, Bostanci I, Atli O, Dallar Y. An infantile Cushing Syndrome due to misuse of topical steroid. Pediatr Dermatol;21:561-563.
  4. Nur B, Karagüzel G, Türkkahraman D, Akçurin S, Bircan İ. Topi- kal steroid kullanımına bağlı iyatrojenik Cushing sendromu: İki va- kanın takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2007;50:125 Turpeinen M, Salo OP, Leisti S. Effect of percutaneous absorpti- on of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease. Br J Dermatol. 1986;115:475-484.
  5. Gen R, Akbay E, Sezer K. Cushing Syndrome caused by topical corticosteroid: a case report. Am J of Med Sci. 2007;333:173 Kumar S, Singh RJ, Reed AM, Lteif AN. Cushing’s syndrome af- ter intra-articuler and intradermal administration of triamsinolo- ne acetonide in three pediatric patients. Pediatrics 2004;113:1820 Main KM, Skov M, Sillesen IB, Dige-Petersen H, Müller J, Koch C, Lanng S. Cushing’s syndrome due to pharmacological interacti- on in a cystic fibrosis patient. Acta Paediatr 2002;91:1008-1011.
  6. Horani MH, Silverberg AB. Secondary Cushing’s syndrome after a single epidural injection of a corticosteroid. Endocr Pract. 2005;11:408-410.
  7. Perry RJ, Findlay CA, Donaldson MDC. Cushing’s syndrome, growth impairment, and occult adrenal supression associated with intranasal steroids. Arch Dis Child 2002;87:45-48
  8. Ozon A, Cetinkaya S, Alikasifoglu A, Gonc EN, Sen Y, Kandemir N. Inappropriate use of potent topical glucocorticoids in infants. J of Pediatr Endocrinol Metab 2007;20:219-225.
  9. Gonc EN, Kandemir N, Kinik ST. Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res 2003;60:191-197.
  10. Ermis B, Ors R, Tastekin A, Ozkan B. Cushing’s syndrome se- condary to topical corticosteroids abuse. Clin Endocrinol (Oxf).;58:795-796.
  11. Çakır M, Ağırman İ, Mungan İ, Orhan F, Ökten A. Topikal ste- roid kullanımına bağlı iyatrojenik Cushing sendrom. Türk Pediatri Arşivi 2005; 40: 102- 104. Guven A, Karadeniz S, Aydin O, Akbalik M, Aydin M. Fatal dis- seminated cytomegalovirus infection in an infant with Cushing’s syndrome caused by topical steroid Horm Res. 2005;64:35-38.
  12. Hatipoğlu N, Kurtoğlu S, Keskin M, Ke