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Journals / Türkiye Çocuk Hastalıkları Dergisi / 2017 / Cilt: 11 - Sayı: 1

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Concurrent with Cytomegalovirus Infection

Eozinofili ve Sistemik Semptomların Eşlik Ettiği İlaç Döküntüsü (DRESS) ile Eş Zamanlı Sitomegalovirus Enfeksiyonu

Zeliha HAYTOĞLU
Pages
68–70
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here we report development of the DRESS syndrome and concurrent presence of CMV viral load in a 2-year-old girl who was on phenytoin prophylaxis for febrile seizure.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Drug rash with eosinophilia and systemic symptoms (DRESS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after a 3-6-week exposure to certain drugs, including anticonvulsants.
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Key Findings & Data:Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DRESS.
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Conclusion & Impact:Here we report development of the DRESS syndrome and concurrent presence of CMV viral load in a 2-year-old girl who was on phenytoin prophylaxis for febrile seizure.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after a 3-6-week exposure to certain drugs, including anticonvulsants. Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DRESS. In addition, recent articles have shown that reactivation of other herpesviruses such as human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) might be also implicated in development of DRESS. Here we report development of the DRESS syndrome and concurrent presence of CMV viral load in a 2-year-old girl who was on phenytoin prophylaxis for febrile seizure.

Özet

Eozinofili ve sistemik semptomların eşlik ettiği ilaç döküntüsü (DRESS) genellikle antikonvülzanların dahil olduğu birtakım ilaçlara, 3-6 hafta maruz kaldıktan sonra görünen şiddetli çoklu organ aşırı duyarlılık reaksiyonu ile karakterizedir. Birçok çalışmada insan Herpes Virüs 6 (HHV-6) reaktivasyonunun DRESS gelişimine katkıda bulunduğu gösterilmiştir. Bununla birlikte yakın dönemdeki çalışmalarda diğer Herpes virüslerden, Herpes virüs 7 (HHV-7), Ebstein-Barr virüs (EBV) ve Sitomegalovirus (CMV) reaktivasyonunun DRESS gelişimiyle ilişkili olduğu gösterilmiştir. Burada febril konvülsiyon profilaksisi için fenitoin kullanmakta olan 2 yaşında bir kız çocuğunda DRESS gelişimi ve eş zamanlı CMV viral yük varlığı gösterilmiştir.

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Cite This Article

HAYTOĞLU, Z. (2022). Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Concurrent with Cytomegalovirus Infection. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 11 - Sayı: 1, 68–70. https://ajindex.com/articles/627337

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