Journals / Türkiye Çocuk Hastalıkları Dergisi / 2019 / Cilt: 13 - Sayı: 4

Evaluation of Immunoglobulin Levels According to Wheezing Phenotypes in Preschool Children With Recurrent Wheezing/ Bronchiolitis

Tekrarlayan Bronşioliti/Hışıltısı Olan Okul Öncesi Çocuklarda İmmünglobulin Düzeylerinin Hışıltı Fenotiplerine Göre Değerlendirilmesi

Pages
234–239
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

IgA levels in EVW group (43.3±35 mg/dl) were found lower than MTW group (74.1±45.1) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Recurrent bronchiolitis/wheeze is frequent in preschool children.
📊
Key Findings & Data:Material and Methods: Children ≤4 years of age with the history of at least three episodes of acute bronchiolitis/ wheeze during the last 12 months included in study.
💡
Conclusion & Impact:IgA levels in EVW group (43.3±35 mg/dl) were found lower than MTW group (74.1±45.1) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Recurrent bronchiolitis/wheeze is frequent in preschool children. Episodic viral wheeze (EVW) and mutitrigger wheezing (MTW) phenotypes have been described. Our aim was to evaluate whether immunoglobulin levels differ in children with episodic and multitrigger wheezing. Material and Methods: Children ≤4 years of age with the history of at least three episodes of acute bronchiolitis/ wheeze during the last 12 months included in study. Patients were evaluated according to wheezing phenotypes as episodic and multi-trigger wheezing. Eosinophil count, eosinophil %, IgA, G, M levels were recorded. Results: 86 (55 male, 31 female) children with recurrent bronchiolitits were included in study. IgA levels in EVW group (43.3±35 mg/dl) were found lower than MTW group (74.1±45.1) (p

Özet

Amaç: Tekrarlayan bronşiolit/hışıltı okul öncesi dönemde sık görülmektedir. Epizodik hışıltı ve çoklu tetikleyici hışıltıfenotipleri tanımlanmıştır. Çalışmamızın amacı, epizodik hışıltı (EH) ve çoklu tetikleyici hışıltısı (ÇTH) olan çocuklarınimmünglobulin düzeylerinde fark olup olmadığını belirlemektir.Gereç ve Yöntemler: Tekrarlayan bronşiolit/hışıltısı olan 4 yaş altındaki son bir yılda en az 3 bronşiolit/hışıltı atağıgeçirmiş olan çocuklar çalışmaya alındı. Hastalar fenotiplere göre epizodik ve çoklu tetikleyici hışıltı olarak iki gruptaincelendi. Eozinofil sayısı, eozinofil yüzdesi, immünglobulin (Ig) A, G, M düzeyleri kayıt edildi.Bulgular: Tekrarlayan bronşioliti/hışıltısı olan 86 çocuk (55 erkek, 31 kız) çalışmaya alındı. IgA düzeyi EH (43.3±35 mg/dl) olan grupta ÇTH grubuna (74.1±45.1 mg/dl) göre daha düşük bulundu (p

🔖

Cite This Article

ÖZBEK, Ö. Y., KÖKSAL, B. (2022). Evaluation of Immunoglobulin Levels According to Wheezing Phenotypes in Preschool Children With Recurrent Wheezing/ Bronchiolitis. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 13 - Sayı: 4, 234–239. https://ajindex.com/articles/627227

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332:133-8
  2. Whelan MA, Hwan WH, Beausoleil J, Hauck WW, McGeady SJ. Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. J Clin Immunol 2006;26:7-11
  3. Kocacık Uygun DF, Filiz S, Yeğin O. Süt çocukluğunun geçici hipogamaglobulinemi ön tanılı olgularımızın değerlendirilmesi. J Pediatr Res 2015;2:128-33
  4. Taussing LM, Wright AL, Holberg CJ, Halonen M, Morgan WS, Martinez FD, et al. Tuscon Children’s Respiratory Study: 1980 to present. J Allergy Clin Immunol 2003; 111:661-75
  5. Brand PL, Baraldi E, Bisgaard H, Boner AL, Castro-Rodriguez JA, Custovic A, et al. Definition, assessment and treatment of wheezing. Eur Respir J 2008;32:1096-110
  6. Tezcan I, Berkel AI, Ersoy F, Sanal O. Serum immunoglobulin levels with turbidimetric method in healthy Turkish children and adults. Turkish J Pediatr Dis 1996;39:649-56
  7. Castro-Rodriguez JA. The Asthma Predictive Index: A very useful tool for predicting asthma in young children. J Allergy Clin Immunol 2010;126:212-6
  8. Guilbert TW, Morgan WJ, Krawiec M, Lemanske RF. The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Control Clin Trials 2004;25:286-310
  9. Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert TW, et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med 2005;172:1253-8
  10. Savenije OE, Kerkhof M, Koppelman GH, Postma DS. Predicting who will have asthma at school age among preschool children. J Allergy Clin Immunol 2012;130:325-31
  11. Castro-Rodríguez JA, Rodrigo GJ. Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics 2009;123:e519-25
  12. Määttä AM, Kotaniemi-Syrjänen A, Malmström K, Malmberg LP, Sundvall J, Pelkonen AS, et al. Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms. Ann Allergy Asthma Immunol 2017;119:227-31
  13. Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T, et al. Risk factors for infantile atopic dermatitis and recurrent wheezing. J Investig Allergol Clin Immunol 2012;22:116-25
  14. Hansbro NG, H