Journals / Türkiye Çocuk Hastalıkları Dergisi / 2019 / Cilt: 13 - Sayı: 2

Evaluation of the Relationship Between Congenital Hypothyroidism and Intraventricular Hemorrhage in the Very Low Birth Weight Infants

Çok Düşük Doğum Ağırlıklı Prematürelerde Konjenital Hipotiroidi İle İntraventriküler Kanama İlişkisinin Değerlendirilmesi

Pages
45–49
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Gestational age (27.3 ± 1.04 weeks) and BW (978 ± 197 g) were lower in the infants with CH than without CH (GA 28.1 ± 1.2 weeks, BW 1073 ± 226 g) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: High thyroid hormone levels have been declared to increase the risk of venous thromboembolism while low levels increasing the risk of bleeding.
📊
Key Findings & Data:Material and Methods: Data of the VLBW infants admitted to the neonatal intensive care unit were retrospectively recorded between January 2013 and December 2016.
💡
Conclusion & Impact:Gestational age (27.3 ± 1.04 weeks) and BW (978 ± 197 g) were lower in the infants with CH than without CH (GA 28.1 ± 1.2 weeks, BW 1073 ± 226 g) (p
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: High thyroid hormone levels have been declared to increase the risk of venous thromboembolism while low levels increasing the risk of bleeding. However, the relations between congenital hypothyroidism (CH) and intraventricular hemorrhage (IVH), especially in the preterm infants, is unknown. In our study, we aimed to investigate the relation between severe intracranial hemorrhage and CH in the very low birth weight (VLBW) infants. Material and Methods: Data of the VLBW infants admitted to the neonatal intensive care unit were retrospectively recorded between January 2013 and December 2016. Gestational age (GA), birth weight (BW), gender, 1st and 5th minute Apgar score, antenatal steroid administration, maternal thyroid disease, cranial ultrasonography findings, thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were obtained from the hospital records. Demographic characteristics and IVH were compared between the groups with and without CH. Results:CH was detected in 26 (4.5 %) of 581 VLBW infants. Gestational age (27.3 ± 1.04 weeks) and BW (978 ± 197 g) were lower in the infants with CH than without CH (GA 28.1 ± 1.2 weeks, BW 1073 ± 226 g) (p

Özet

Amaç: Düşük tiroid hormon düzeylerinin kanama, yüksek düzeylerin ise venöz tromboemboli riskini artırdığı bildirilmiştir.Ancak özellikle preterm bebeklerde konjenital hipotiroidizm (KH) ve intraventriküler hemoraji (İVH) arasındaki ilişkibilinmemektedir. Çalışmamızda çok düşük doğum ağırlıklı (ÇDDA) preterm bebeklerde şiddetli intrakraniyal kanama ileKH arasındaki ilişkinin araştırılması amaçlanmıştır.Gereç ve Yöntemler: Ocak 2013 ile Aralık 2016 tarihleri arasında, yenidoğan yoğun bakım ünitesine yatan ÇDDAhastaların verileri retrospektif olarak kayıt edildi. Hastaların gebelik haftaları (GH), doğum ağırlığı (DA), cinsiyeti, 1. ve 5.dakika Apgar skoru, antenatal steroid uygulaması, annede tiroid hastalığı, kraniyal ultrasonografi bulgusu, tiroid stimülanhormon (TSH) ve serbest tiroksin (sT4) düzeylerini içeren verileri kayıt edildi. Konjenital hipotiroidi olan ve olmayanhastalar demografik özellikler ve ciddi İVK açısından karşılaştırıldı.Yenidoğan yoğun bakım ünitesine yatırılan ÇDDA bebeklerin verileri retrospektif olarak Ocak 2013 ile Aralık 2016 arasındakaydedildi. Gebelik haftası (GH), doğum ağırlığı (DA), cinsiyet, 1. ve 5. Apgar skoru, antenatal steroid uygulanması,maternal tiroid hastalığı, kraniyal ultrasonografi tetkik raporları ve tiroid uyarıcı hormon (TSH) ve serbest tiroksin (sT4)düzeyleri hastanın tıbbi kayıtlarından elde edildi. Demografik özellikler ve intraventriküler hemoraji, KH olan ve olmayangruplar arasında karşılaştırıldı.Bulgular: Çalışmamızda 581 ÇDDA bebeğin 26’sında (% 4.5) KH saptanmıştır. Gebelik haftası (27.3 ± 1.04 hafta) veDA (978 ± 197 g), KH olan bebekler, KH olmayanlardan (GA 28.1 ± 1.2 hafta, DA 1073 ± 226 g) daha düşüktü (sırasıyla,p

🔖

Cite This Article

TAYMAN, C., YAKUT, H. İ., ÇAKIR, U. (2022). Evaluation of the Relationship Between Congenital Hypothyroidism and Intraventricular Hemorrhage in the Very Low Birth Weight Infants. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 13 - Sayı: 2, 45–49. https://ajindex.com/articles/627187

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Belcari F, Placidi G, Guzzetta A, Tonacchera M, Ciampi M, Bartoli A, et al. Thyroid-stimulating hormone levels in the first days of life and perinatal factors associated with sub-optimal neuromotor outcome in preterm infants. J Endocrinol Invest 2011;34:e308-13
  2. Lee JH, Kim SW, Jeon GW, Sin JB. Thyroid dysfunction in very low birth weight preterm infants. Korean J Pediatr 2015;58:224-9
  3. Heidari Z, Feizi A, Hashemipour M, Kelishadi R, Amini M. Growth development in children with congenital hypothyroidism: the effect of screening and treatment variables-a comprehensive longitudinal study. Endocrine 2016;54:448-59
  4. Baysal BT, Baysal B, Genel F, Erdur B, Ozbek E, Demir K, et al. Neurodevelopmental Outcome of Children with Congenital Hypothyroidism Diagnosed in a National Screening Program in Turkey. Indian Pediatr 2017;54:381-4
  5. Osborn DA, Hunt RW. Prophylactic postnatal thyroid hormones for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2007;(1):CD005948
  6. LaFranchi S. Thyroid function in the preterm infant. Thyroid 1999;9:71-8
  7. Hashemipour M, Hovsepian S, Ansari A, Keikha M, Khalighinejad P, Niknam N. Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review. PediatrNeonatol 2018;59:3-14
  8. Vigone MC, Caiulo S, DiFrenna M, Ghirardello S, Corbetta C, Mosca F, et al. Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism. J Pediatr 2014;164:1296-302
  9. Dhital R, Poudel DR, Tachamo N, Gyawali B, Basnet S, Shrestha P, et al. Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies. J Stroke Cerebrovasc Dis 2017;26:2926-34
  10. Akirov A, Shochat T, Shechvitz A, Shimon I, Diker-Cohen T, Robenshtok E. Pre-admission TSH levels predict long-term mortality in adults treated for hypothyroidism. Endocrine 2017;58:481-7
  11. Weng CH, Chen YH, Lin CH, Luo X, Lin TH. Thyroid disorders and breast cancer risk in Asian population: a nationwide populationbased case-control study in Taiwan. BMJ Open 2018;8:e020194
  12. Suvarna JC, Fande CN. Serum thyroid hormone profile in critically Ill children. Indian J Pediatr 2009;76:1217-21
  13. Elbers LPB, Fliers E, Cannegieter SC. The influence of thyroid function on the coagulation system and its clinical consequences. J ThrombHaemost 2018;16:634-645
  14. Tan AP, Svrckova P, Cowan F, Chong WK, Manka