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Journals / Türkiye Çocuk Hastalıkları Dergisi / 2019 / Cilt: 13 - Sayı: 2

Evaluation of the Relationship Between Thyroid Functions and Disease Outcome in Children with Acute Liver Failure

Akut Karaciğer Yetmezliği Olan Çocuklarda Tiroid Hormonlarının ve Hastalığın Seyri ile İlişkisinin Değerlendirilmesi

Figen ÖZÇAY
Oya BALCI SEZER
Zeren BARIŞ
Pages
87–94
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Total and direct bilirubin levels, INR and PELD values were significantly higher in group 2 compared to the levels of group 1 (p=0.022, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We investigated if serum TSH, free T4 and free T3 could be prognostic factors in patients with acute liver failure.
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Key Findings & Data:Material and Methods: There were 39 out of 108 children with acute liver failure who applied to our hospital between 2000-2017 and whose thyroid function tests were measured at the time of arrival.
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Conclusion & Impact:Total and direct bilirubin levels, INR and PELD values were significantly higher in group 2 compared to the levels of group 1 (p=0.022, p
🔬Design:Research Article
📍Scope:2000-2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We investigated if serum TSH, free T4 and free T3 could be prognostic factors in patients with acute liver failure. Material and Methods: There were 39 out of 108 children with acute liver failure who applied to our hospital between 2000-2017 and whose thyroid function tests were measured at the time of arrival. We retrospectively collected the clinical and laboratory parameters of these 39 patients, and evaluated the relationship between thyroid hormones and prognosis of the patients. Results: TSH levels were low in 29/39 (74.4%) patients, while 27/29 (93.1%) patients had low fT3 levels. Free T4 levels were normal in 25/36 (69.4%) and low in 6/36 (16.7%) patients. Patients were divided into two groups according to disease course: group 1 (n=17) included patients with spontaneous resolution and group 2 (n=22) included patients who either died or underwent liver transplantation. Total and direct bilirubin levels, INR and PELD values were significantly higher in group 2 compared to the levels of group 1 (p=0.022, p

Özet

Amaç: Çalışmamızda akut karaciğer yetmezliği ile başvuran çocuk hastalarda TSH, serbest T4 ve serbest T3 düzeylerininhastalık seyrini belirlemedeki etkilerini inceledik.Gereç ve Yöntemler: Çalışmaya hastanemize 2000-2017 yılları arasında akut karaciğer yetmezliği ile başvuran 108hasta içerisinden, başvuru sırasında tiroid hormonları bakılmış olan 39 hasta alındı. Bu hastaların geriye dönük olarakklinik ve laboratuvar bulguları değerlendirilerek, başvuru sırasındaki tiroid hormonları ile hastalığın seyri arasındaki ilişkiincelendi.Bulgular: TSH düzeyleri hastaların 29/39’unda (%74.4) normalden düşük, serbest T3 düzeyleri 27/29 hastada (%93.1)normalden düşük saptanmıştır. Serbest T4 düzeyleri ise hastaların %69.4’sında (25/36 hasta) normal, %16.7’sinde(6/36 hasta) düşük düzeylerde bulunmuştur. Hastalar, hastalığın seyrine göre, kendiliğinden düzelen hastalar (Grup 1) ilekaybedilen/nakil olan hastalar (Grup 2) olarak iki gruba ayrılmıştır. Grup 2’deki hastaların başvuru sırasında bakılan INR,total ve direk bilirubin düzeyleri ve PELD skorları grup 1’deki hastalara göre istatistiksel olarak anlamlı şekilde yüksekbulunmuştur (sırasıyla p=0.022, p

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Cite This Article

ÖZÇAY, F., SEZER, O. B., BARIŞ, Z. (2022). Evaluation of the Relationship Between Thyroid Functions and Disease Outcome in Children with Acute Liver Failure. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 13 - Sayı: 2, 87–94. https://ajindex.com/articles/627142

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