Journals / Türkiye Çocuk Hastalıkları Dergisi / 2020 / Cilt: 14 - Sayı: 2

Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU

Yenidoğan Yoğun Bakım Ünitesinde PCR ile Kanıtlanmış RSV ve RSV dışı Virüslerin Neden Olduğu Akut Alt Solunum Yolu Enfeksiyonları

Pages
168–175
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Inmultivariate analysis, apnea and RSV were found to be risk factors for respiratory support requirement.Conclusion: Since RSV-associated acute lower respiratory tract infections are the most common and require morerespiratory support in the neonatal period, risk factors should be identified and preventive measures should be developed.Preventive strategies, raising awareness of families, careful and meticulous attitudes especially during high season mightreduce the incidence and hospitalizations of the infants

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In recent years, detection of viruses by multiplex real time polymerase chain reaction allowed the isolationof causative viral agents.The primary objectives of this study were to determine the distribution of causative respiratory viruses in acute lowerrespiratory tract infections in the NICU and to compare the demographic and clinical characteristics of infants with RSVand non-RSV infections.
📊
Key Findings & Data:The secondary aim was to determine risk factors requiring respiratory support.Material and Methods: This retrospective observational study was conducted between January 2016 and June 2019.The infants were divided into two groups as RSV and non-RSV, and compared.
💡
Conclusion & Impact:Inmultivariate analysis, apnea and RSV were found to be risk factors for respiratory support requirement.Conclusion: Since RSV-associated acute lower respiratory tract infections are the most common and require morerespiratory support in the neonatal period, risk factors should be identified and preventive measures should be developed.Preventive strategies, raising awareness of families, careful and meticulous attitudes especially during high season mightreduce the incidence and hospitalizations of the infants
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In recent years, detection of viruses by multiplex real time polymerase chain reaction allowed the isolationof causative viral agents.The primary objectives of this study were to determine the distribution of causative respiratory viruses in acute lowerrespiratory tract infections in the NICU and to compare the demographic and clinical characteristics of infants with RSVand non-RSV infections. The secondary aim was to determine risk factors requiring respiratory support.Material and Methods: This retrospective observational study was conducted between January 2016 and June 2019.The infants were divided into two groups as RSV and non-RSV, and compared. Risk factors for respiratory support bymeans of invasive/non-invasive ventilation were determined.Results: Two hundred forty-three infants were hospitalized with the diagnosis of viral lower respiratory tract infectionsand a total of 119 infants, in which a causative viral agent could be isolated, were included in the study. RSV was themost common detected virus (n=93, 78%). The demographic characteristics of infants in RSV and non-RSV groupswere similar, except postnatal age. Infants were hospitalized most frequently in between December and February. Inmultivariate analysis, apnea and RSV were found to be risk factors for respiratory support requirement.Conclusion: Since RSV-associated acute lower respiratory tract infections are the most common and require morerespiratory support in the neonatal period, risk factors should be identified and preventive measures should be developed.Preventive strategies, raising awareness of families, careful and meticulous attitudes especially during high season mightreduce the incidence and hospitalizations of the infants

Özet

Amaç: Son yıllarda virusların mutipleks gerçek zamanlı polimeraz zincir reaksiyonu ile belirlenmesi, enfeksiyonlara neden olan viral ajanların izole edilmesine imkan sağlamıştır. Bu çalışmanın birincil amacı yenidoğan yoğun bakım ünitesinde akut alt solunum yolu enfeksiyonuna neden olan solunum yolu viruslarının dağılımını belirlemek ve RSV ve RSV dışı enfeksiyonu olan bebeklerin demografik ve klinik özelliklerini karşılaştırmaktır. İkincil amacı ise solunum desteği gerektiren risk faktörlerinin belirlenmesidir. Gereç ve Yöntemler: Bu geriye dönük gözlemsel çalışma Ocak 2016 ile Haziran 2019 yılları arasında yapıldı. Bebekler RSV ve RSV dışı olmak üzere iki gruba ayrılarak karşılaştırıldı. Solunum desteği gerektiren hastalar (invaziv ve non-invaziv ventilasyon) için risk faktörleri belirlendi. Bulgular: Viral alt solunum yolu enfeksiyonu tanısı ile 243 bebek hastaneye yatırıldı ve bu bebeklerden viral etken saptanan 119’u çalışmaya dahil edildi. En sık saptanan virüs RSV’di (n=93, %78). RSV ve RSV dışı gruplardaki bebeklerin demografik özellikleri postnatal yaş dışında benzerdi. Bebekler en sık Aralık ve Şubat ayları arasında hastaneye yatırıldı. Solunum desteği gerektiren risk faktörlerini belirlemek için yapılan multivariate analizinde apne ve RSV risk faktörü olarak bulundu. Sonuç: Yenidoğan döneminde RSV ile ilişkili akut alt solunum yolu enfeksiyonları en sık görülen ve daha fazla solunum desteği gerektirdiğinden, risk faktörleri tanımlanmalı ve önleyici yöntemler geliştirilmelidir. Önleyici stratejiler, ailelerin farkındalıklarının artırılması, özellikle sezonda dikkatli ve titiz davranışlarla bebeklerde enfeksiyonların görülme sıklığı ve hastaneye yatışlar azalabilir.

🔖

Cite This Article

BİLGİN, B. S., PARLAKAY, A. O., ÜNAL, S., YAZICI, A. (2022). Acute lower respiratory tract infections caused by PCR proven RSV and non-RSV viruses in the NICU. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 14 - Sayı: 2, 168–175. https://ajindex.com/articles/627063

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Perez GF, Pancham K, Huseni S, Jain A, Rodriguez-Martinez CE, Preciado D, et al. Rhinovirus-induced airway cytokines and respiratory morbidity in severely premature children. Pediatr Allergy Immunol 2015; 26: 145-52
  2. Jackson DJ. Early-life viral infections and the development of asthma: a target for asthma prevention. Curr Opin Allergy Clin Immunol 2014;14:131-6
  3. Liolios L, Jenney A, Spelman D, Kotsimbos T, Catton M, Wesselingh S. Comparison of a multiplex reverse transcriptionPCR-enzyme hybridization assay with conventional viral culture immunofluorescence techniques for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001;39:2779-78
  4. William BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distrubution of child deaths from acute respiratory infections. Lancet Infect Dis 2012;2:25-32
  5. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-128
  6. Hacımustafaoğlu M, Celebi S, Bozdemir SE, Ozgür T, Ozcan I, Güray A, et al. RSV frequency in children below 2 years hospitalized for lower respiratory tract infections. Turk J Pediatr 2013;55:130-9
  7. Alan S, Erdeve O, Cakir U, Akduman H, Zenciroglu A, Akcakus M, et al. Outcome of the respiratory syncytial virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study. J Matern Fetal Neonatal Med 2016;29:2186-93
  8. Türk Neonatoloji Derneği Palivizumab ile RSV proflaksisi önerileri. 2018.11 Temmuz. http=//www.neonatology.org.tr/ 9. Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A et al. Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants. Ital J Pediatr 2014;40:65
  9. Cho HJ, Shim SY, Son DW, Sun YH, Tchah H, Jeon IS. Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections. Pediatr Int 2013;55:49-53
  10. Okulu E, Akduman H, Tunç G, Çiftçi E, İnce E, Erdeve Ö ve ark. Viral alt solunum yolu enfeksiyonu nedeniyle yatırılan yenidoğanların epidemiyolojik ve klinik özellikleri. Türkiye Çocuk Hast Derg 2018;1: 31-5
  11. Celik K, Olukman O, Demirol H, Terek D, Gulfidan G, Devrim I, et al. Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center. Arch Argent