Journals / Türkiye Çocuk Hastalıkları Dergisi / 2020 / Cilt: 14 - Sayı: EK SAYI 1

Hematologic Parameters of Patients with COVID-19 Infection

COVID-19’lu Hastalarda Görülen Hematolojik Parametreler

Pages
48–50
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Dysplastic morphological changes in neutrophils and platelets can be detected in peripheral smear of patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:SARS-CoV-2 causes primarily respiratory tract infection, but can also affect hematopoietic and immune systems.
📊
Key Findings & Data:Lymphopenia is the most common finding in adult patients infected with SARS-CoV-2, while it is much less common in children.
💡
Conclusion & Impact:Dysplastic morphological changes in neutrophils and platelets can be detected in peripheral smear of patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:COVID-19 · Hematology · lymphocyte

Abstract

SARS-CoV-2 causes primarily respiratory tract infection, but can also affect hematopoietic and immune systems. Quantitative and qualitative changes in lymphocytes, neutrophils, monocytes and platelets, are reported in infected patients. These changes are related to the severity of the disease. Lymphopenia is the most common finding in adult patients infected with SARS-CoV-2, while it is much less common in children. Leukocytosis can be detected in patients with severe infection, but rare in patients with mild to moderate infection. Thrombocytopenia or thrombocytosis can also be seen in accordance with the clinic. Dysplastic morphological changes in neutrophils and platelets can be detected in peripheral smear of patients.

Özet

SARS-CoV-2 primer olarak solunum yolu enfeksiyonuna neden olmakla birlikte hematopoietik ve immun sistemlerini de etkileyebilmektedir. Enfekte olan hastalarda, lenfositler, nötrofiller, monositler ve trombositlerde kantitatif ve kalitatif değişiklikler bildirilmektedir. Bu değişiklikler ile hastalığın şiddeti arasında ilişki olduğu da gösterilmiştir. Lenfopeni, SARS-CoV-2 ile enfekte erişkin hastalarda en sık görülen bulgu iken çocuklarda çok daha az görülmektedir. Şiddetli enfeksiyonu olan hastalarda lökositoz saptanabilir, hafif-orta şiddette enfeksiyonu olan hastalarda ise lökositoz daha nadirdir. Klinik ile uyumlu olarak trombositopeni veya trombositoz da görülebilmektedir. Hastaların periferik yaymalarında özellikle nötrofil ve trombositlerde displastik morfolojik değişikler saptanabilir.

🔖

Cite This Article

YARALI, H. N., YOZGAT, A. K. (2022). Hematologic Parameters of Patients with COVID-19 Infection. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 14 - Sayı: EK SAYI 1, 48–50. https://ajindex.com/articles/627042

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020 Feb 20; 382: 727-33
  2. World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 — 11 March 2020. March 11, 2020. https://www.who.int/dg/speeches/detail/whodirector-general-s-opening-remarks-at-the-media-briefing-oncovid-19—11-march-2020 (accessed March 12, 2020
  3. Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K. COVID-19 (novel coronavirus 2019) — recent trends. Eur Rev Med Pharmacol Sci 2020; 24(4): 2006–2011 4. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. JAMA. 2020 [Epub ahead of print].
  4. Liang W, Guan W, Chen R, Wang W, Li J, Xu K et al Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21:335–7
  5. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395: 565–74 7. Li T, Lu H, Zhang W. Clinical observation and management of COVID-19 patients. Emerg Microbes Infect 2020; 9: 687-90
  6. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020 Feb 28. [Epub ahead of print] doi: 10.1056/NEJMoa2002032 9. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395(10224): 565–574 10. Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020 Feb 24; 12(1): 8
  7. Singh S, Sharma A, Arora SK. High producer haplotype (CAG) of -863C/A, -308G/A and -238G/A polymorphisms in the promoter region of TNF-alpha gene associate with enhanced apoptosis of lymphocytes in HIV-1 subtype C infected individuals from North India. PLoS One 2014; 9: e98020
  8. Liao YC, Liang WG, Chen FW, Hsu JH, Yang JJ, Chang MS. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. J Immunol 2002; 169: 4288-97
  9. Aggarwal S, Gollapudi S, Gupta S. Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases. J Immunol 1999; 162: 2154-61
  10. Chan JF, Z