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Journals / Türkiye Aile Hekimliği Dergisi / 2014 / Cilt: 18 - Sayı: 3

Esophageal ulcer development after a single dose of Doxycycline: A case report

Tek doz Doksisiklin kullanımına bağlı gelişen özofagus ülseri: Bir olgu sunumu

Hüseyin ATASEVEN
Seher SAYIN
Ruhuşen KUTLU
Serhat SAYIN
Pages
156–158
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As in our case, irrespective of the exposure duration,even after a single dose, esophageal ulcer may develop.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although it is not so frequent in medical literature, drug-inducedesophageal ulcer is important due to its possible complications.Doxycycline can cause esophagial irritation if not taken withsuffcient water or just before going to sleep.
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Key Findings & Data:In this case report, a24 year-old female patient who had been prescribed doxycylinefor acne is presented.
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Conclusion & Impact:As in our case, irrespective of the exposure duration,even after a single dose, esophageal ulcer may develop.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Although it is not so frequent in medical literature, drug-inducedesophageal ulcer is important due to its possible complications.Doxycycline can cause esophagial irritation if not taken withsuffcient water or just before going to sleep. In this case report, a24 year-old female patient who had been prescribed doxycylinefor acne is presented. She was admitted with retrosternal painand dysphagia which had started after taking the frst oraldose of the drug. Endoscopic examination showed superfcialulcerations in the area of 2 cm of the mid esophagus. Basedon the endoscopic fndings, the patient was diagnosed as drug- induced esophageal injury resulting from doxycycline treatment.Doxycycline treatment and oral intake were stopped. Intravenousfuid therapy, sucralfate and lansoprazole treatment were started.In the following days, the patient s complaints disappearedgradually. As in our case, irrespective of the exposure duration,even after a single dose, esophageal ulcer may develop.

Özet

İlaca bağlı özofagus ülseri literatürde sık görülmemeklebirlikte yol açabileceği komplikasyonlar açısından önemlidir.Doksisiklin yeterli miktarda su ile alınmaz ise veya alındıktankısa süre sonra yatılırsa özofagusta mukozal hasara neden olur. Bu olguda akne nedeniyle doksisiklin tedavisi başlanmış 24yaşındaki kadın hasta sunuldu. Hasta ilacın ilk dozundan sonraretrosternal yanma, disfaji semptomlarıyla başvurdu. Yapılanüst gastrointestinal sistem endoskopisinde özofagus 1/3 ortabölümünde 2 santimetrelik bir segmentte yüzeyel ülserasyonlargörüldü. Anamnez ve endoskopik bulgularla, hastaya doksisiklinkullanımına bağlı ilaç özofajiti teşhisi konuldu. Doksisiklintedavisi ve oral alımı kesildi. İntravenöz sıvı tedavisi, sukralfatve lansoprazol tedavisi başlandı. İlerleyen günlerde hastanınşikâyetleri azalarak kayboldu. Olgumuzda olduğu gibi, ilacınsüresinden bağımsız olarak tek doz kullanım sonrasında dahiözofageal ülser gelişebilmektedir.

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Cite This Article

ATASEVEN, H., SAYIN, S., KUTLU, R., SAYIN, S. (2022). Esophageal ulcer development after a single dose of Doxycycline: A case report. Türkiye Aile Hekimliği Dergisi, Cilt: 18 - Sayı: 3, 156–158. https://ajindex.com/articles/626774

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