Journals / Türkiye Acil Tıp Dergisi / 2005 / Cilt: 5 - Sayı: 4

Serum levels of ischemia-modified albumin (IMA) in healthy adults and patients with acute coronary syndrome.

Sağlıklı erişkinlerde ve akut koroner sendromlu hastalarda serum iskemi modifiye albumin (İMA) düzeyleri

Pages
169–174
Publication Date
2022-11-05
DOI
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Serum IMA levels were significantly higher in ACS patients compared to healthy group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Serum levels of ischemia-modified albumin (IMA) has recently been introduced as an early marker of myocardial ischemia in management of patients with acute coronary syndrome (ACS).
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Key Findings & Data:Material and Method: The serum IMA levels of healthy adults as control group and patients with ACS who had increased myoglobin, troponin T and CK-MB levels during the following 6-24 hours although their cardiac markers were normal initially.
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Conclusion & Impact:Serum IMA levels were significantly higher in ACS patients compared to healthy group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Serum levels of ischemia-modified albumin (IMA) has recently been introduced as an early marker of myocardial ischemia in management of patients with acute coronary syndrome (ACS). The present study aimed to determine the serum IMA levels in healthy adults and ACS patients and also its effectiveness in diagnosing myocardial ischemia. Material and Method: The serum IMA levels of healthy adults as control group and patients with ACS who had increased myoglobin, troponin T and CK-MB levels during the following 6-24 hours although their cardiac markers were normal initially. Furthermore the effects of age and gender on serum IMA levels were investigated. Results: There were 196 healthy subjects of which 109 were female (mean age: 48.7 ± 19 years), 87 male (mean age: 44.8 ± 17 years) in the control group. Serum IMA levels were also measured in 41 ACS patients (mean age: 60 ± 13 years, 4 female and 37 male). Serum IMA levels showed a normal distribution in healthy adults. Serum IMA level covering 95% of whole study group was 59.08 ± 13.0 U/mL. Neither gender nor age affected serum IMA levels significantly. Serum IMA levels were significantly higher in ACS patients compared to healthy group (p

Özet

Giriş: Serum iskemi modifiye albumin (IMA) düzeyleri son yıllarda miyokard iskemisini gösteren erken bir belirteç olarak Akut Koroner Sendrom (AKS) düşünülen hastaların değerlendirilmesinde kullanılmaya başlanmıştır. Bu çalışmada, sağlıklı yetişkinler ve AKS'li hastalarda IMA serum düzeylerinin saptanması ve miyokard iskemisi tanısındaki geçerliliğinin ölçülmesi amaçlanmıştır. Gereç ve Yöntem: Acil serviste AKS ön tanısı ile değerlendirilen ve ölçülen ilk myoglobin, troponin T ve CK-MB düzeyleri yüksek olmayan, ancak takip eden 6-24 saat içinde bu değerleri yükselen hastalardan ve sağlıklı erişkinlerden oluşan kontrol grubunun serum IMA düzeyleri ölçüldü. Yaş ve cinsiyetin serum IMA düzeyleri üzerindeki etkisi incelendi. Bulgular: Kontrol grubunda 109 kadın (yaş ortalaması: 48.7 ± 19 yıl), 87 erkek (yaş ortalaması: 44.8 ± 17 yıl) toplam 196 sağlıklı kişinin serum IMA düzeyleri ölçüldü. AKS grubunda ise, 4'ü kadın, 37'si erkek toplam 41 hastada (yaş ortalaması 60 ± 13 yıl) serum IMA düzeyleri ölçüldü. Sağlıklı yetişkinlerde serum IMA düzeyleri normal bir dağılım gösterdi. Tüm çalışma grubunun %95'ini kapsayan serum IMA değeri 59.08 ± 13.0 U/mL olarak bulundu. Cinsiyet ve yaş serum IMA düzeylerini anlamlı olarak etkilemedi. Sağlıklı grup ile karşılaştırıldığında, AKS'li hastalarda serum IMA düzeyleri anlamlı olarak daha yüksekti (p

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Cite This Article

AKBAŞ, H., ÖZDEN, S., DÖNMEZ, L., BAŞARICI, İ., BAKTIR, A., GÜLTEKİN, M., ÇETE, Y. (2022). Serum levels of ischemia-modified albumin (IMA) in healthy adults and patients with acute coronary syndrome.. Türkiye Acil Tıp Dergisi, Cilt: 5 - Sayı: 4, 169–174. https://ajindex.com/articles/626208

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