Seizure due to low dose meperine: a case report

Key Findings & Data:Previously identified risk factors for the development of meperi-dine-related seizures include renal failure, high meperidine dosages, and co-administration of hepatic enzyme-induc¬ing medications or phenothiazines which decreases seizure treshold.

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Conclusion & Impact:Here we reported a case of tonic donic seizure due to the low dose meperidine in a patient with normal renal function.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Meperidine is an opioid analgesic used in a variety of clinical situations. The active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to causes irritability, hyperreflexia, tremor, myodonus and seizures especially in patients with renal failure. Previously identified risk factors for the development of meperi-dine-related seizures include renal failure, high meperidine dosages, and co-administration of hepatic enzyme-induc¬ing medications or phenothiazines which decreases seizure treshold. Patients with normal renal function rarely manifest seizure activity when given meperidine. Here we reported a case of tonic donic seizure due to the low dose meperidine in a patient with normal renal function.

Özet

Meperidin çeşitli klinik durumlarda kullanılan opioid analjeziktir. Meperidinin aktif metaboliti olan normeperidinin merkezi sinir sistemi üzerine uyarıcı etkisi olup özellikle böbrek yetersizliği olanlarda daha yüksek oranda irri-tabilite, hiperrefleksi, tremor, miyoklonus ve konvülsif nöbete sebep olabilir. Böbrek yetersizliği, yüksek doz meperidin kullanılması, hepatik enzimleri indükleyen ilaç kullanımı ve nöbet eşiğini düşüren fenotiazinlerin kul¬lanımı meperidine bağlı konvülsif nöbet oluşumuna yol açan risk faktörleri olarak bilinmektedir. Böbrek işlevi nor¬mal hastalarda meperidin kullanımına bağlı konvülsif nöbet oluşumu nadiren görülmektedir. Biz bel ağrısı ile acil servise başvuran ve tedavisinde kullanılan düşük doz meperidine bağlı konvülsif nöbet gelişen normal böbrek fonksiyonlu olguyu sunduk.

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Cite This Article

PARLAK, İ., PARLAK, M., AYRIK, C., ERDUR, B., TÜRKÇÜER, İ. (2022). Seizure due to low dose meperine: a case report. Türkiye Acil Tıp Dergisi, Cilt: 7 - Sayı: 2, 79–81. https://ajindex.com/articles/626167

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