AI Summary & Key Takeaways
AI InsightIn patient groups having other left ventricular geometric patterns mean QTD and QTcD were different in hypertensive and LBP periods (for each p
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Abstract
Objectives: Mortality of hypertensive patients is due to systolic and diastolic dysfunction and hypertrophy of left ventricle, coronary artery disease, arrhythmias and sudden death. Measurement of QT dispersion (QTD) is a non-invasive method for evaluation of heterogenity of myocardial repolarization and it is thought to accompany arrhyth-mogenic events. Left ventricular hypertrophy is accepted to be the major factor affecting QTD in hypertensive patients. Aim of this study is to investigate the relation between QTD and left ventricular wall stress caused by an increase in afterload independant from left ventricular hypertrophy in hypertensive urgency patients. Materials and Methods: Standart 12-lead surface electrocardiographic records of 76 patients matching inclu¬sion criteria were taken in hypertensive period and period in which mean blood pressure lowered 10% by Na-nitro-prussid and then QTD and corrected QT dispersion (QTcD) were calculated. Left ventricular geometric patterns were determined by echocardiographic measurements. Results: Mean age of the patients was 57.29+11.3 and 68.4% of them were women. In the hypertensive period mean systolic blood pressure (SBP), QTD and QTcD were 192.11+20.2 mmHg, 45.79±14.90 msec and 54.78+17.96 msec and in lowered blood pressure (LBP) period they are 149.08+11.9 mmHg, 29.47±13.65 msec and 34.06±15.73 msec respectively (pO.001). In 50% of patients concentric hypertrophy and in 11.8% of patients nor¬mal ventricular geometry were detected. According to left ventricular geometry mean QTD and QTcD were similar between the groups in hypertensive and LBP periods. Although mean QTDs were similar (p=0.058) in normal left ventricular geometry group in both hypertensive and LBP periods, mean QTcDs were different (p=0.036). In patient groups having other left ventricular geometric patterns mean QTD and QTcD were different in hypertensive and LBP periods (for each p
Özet
Giriş: Hipertansif bireylerde mortalite nedenleri sol ventrikülün sistolik ve diyastolik disfonksiyonu, hipertrofisi, koroner arter hastalığı, aritmiler ve ani ölümdür. QT dispersiyonu (QTD) ölçümü miyokardial repolarizasyon he-terojeoitesinin değerlendirilmesinde noninvaziv bir yöntem olarak kullanılmakta ve aritmik olaylarla birlikte oldu¬ğu düşünülmektedir. Hipertansif hastalardaki sol ventrikül hipertrofisi QTD değişimindeki major etken olarak ka¬bul görmektedir. Çalışmanın amacı hipertansif urgency hastalarında, sol ventrikül hipertrofisinden bağımsız ola¬rak, afterload artışına bağlı sol ventrikül duvar gerimi ve QT dispersiyonu arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çalışma koşullarına uygun hastalarda hipertansif dönemde ve Na-nitroprussid ile ortalama kan basıncı % 10 düşürülmüş dönemde standart 12 derivasyonlu yüzey elektrokardiyografi kaydı alınarak QTD ve QTc dispersiyonu (QTcD) hesaplandı. Ekokardiyografi ile sol ventrikül geometrik yapısı saptandı. Bulgular: Çalışmaya alınan 76 hastanın yaş ortalaması 57.29±11.3, %68.4'ü kadındı. Hipertansif dönemde ölçülen sistolik kan basıncı (SKB) ortalama 192.11 ±20.2 mmHg, QTD 45.79+14.90 msn ve QTcD 54.78±17.96 msn, kan basıncı düşürülmüş dönemde ortalama SKB 149.08+11.9 mmHg, QTD 29.47+13.65 msn ve QTcD 34.06±15J3 msn saptandı (p