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Journals / Türkiye Acil Tıp Dergisi / 2007 / Cilt: 7 - Sayı: 1

Acil servise akut periferik vertigo ile başvuran hastalarda intravenöz diazepam, dimenhydrinate ve dipenhydramine tedavisinin etkinliğinin karşılaştırılması

Comparison of intravenous diazepam, dimenhydrinate and diphenhydramine on patients with acute peripheral vertigo in the emergency department: A randomized, double blind, clinical trial

Vermi DEĞERLİ
Tanzer KORKMAZ
İbrahim TÜRKÇÜER
Arif Alper ÇEVİK
Pages
10–17
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Diazepam has less sedation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study is to compare treatment and side effects of intraveneous (IV) diazepam, diphen­hydramine and dimenhydrinate on patients with vertigo.
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Key Findings & Data:Materials and Methods: Patients over 17 years of age who presented with vertigo as a chief complaint were included in the study. 2 mg diazepam, 50 mg diphenhydramine, or 50 mg dimenhydrinate were given IV over 2 min.
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Conclusion & Impact:Diazepam has less sedation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study is to compare treatment and side effects of intraveneous (IV) diazepam, diphen­hydramine and dimenhydrinate on patients with vertigo. Materials and Methods: Patients over 17 years of age who presented with vertigo as a chief complaint were included in the study. 2 mg diazepam, 50 mg diphenhydramine, or 50 mg dimenhydrinate were given IV over 2 min. Patients evaluated their vertigo perception with Likert numeric (1-10) scale during walking, standing, sitting, and supine positions. Patients also evaluated additional symptoms and side effects at the same times. Principal outcome measures were evaluated at 60 minutes. Results: 74 patients were entered into the study. All three medications were found equally effective to decrease vertigo symptoms. There was no statistical difference between groups for side effects, but at 60 minutes diphen­hydramine and dimenhydrinate caused more sedation than diazepam (p=0.015). Mean level of change in seda­tion and drowsiness was significantly less in the diazepam group than others (p=0.025, p=0.033, respectively). Conclusion: Diazepam, diphenhydramine and dimenhydrinate are equally effective to treat vertigo in the emergen­cy department. Diazepam has less sedation.

Özet

Giriş: Acil servise başdönmesi şikayetiyle başvuran hastalarda1 intravenöz (İ.V.) olarak uygulanan diazepam, diphenhydramine ve dimenhydrinate'in tedavi etkinliği ve görülen yan etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: On yedi yaş üzerinde acil servise esas başvuru şikayeti başdönmesi olan bütün hastalar çalışmaya alındı. 2 mg diazepam, 50 mg diphenhydramine veya 50 mg dimenhydrinate 2 dakikanın üzerinde i. V. olarak uygulandı. Daha sonra hastaların başdönmesi şikayetlerinin şiddeti (yürür, ayakta, oturur ve supin pozisyonlarında) Likert numeric (1-10) skala ile değerlendirildi. Bu sırada hastalarda oluşan ek semptom - bulgular ve yan etkilerde değerlendirmeye alındı. Bu temel değerlendirme ve ölçümler 60 dakika içerisinde yapıldı. Bulgular: Çalışmaya 74 hasta dahil edildi. Üç ilacında başdönmesi semptomlarını azaltma da etkili olduğu bulun­du. Gruplar arasında yan etki oluşması konusunda istatistiksel bir fark bulunmadı. Ama diphenhydramine ve dimenhydrinate'in 60 dakikalık sürede diazepamdan daha fazla sedasyon yaptığı görüldü (p=0.Q15). Diazepam grubunda sedasyon ve sersemlik hissi oluşmasının diğer gruplardan daha düşük düzeyde olduğu bulundu (p=0.025, p=0.033). Sonuç: Diazepam, diphenhydramine ve dimenhydrinate acil serviste baş dönmesi tedavisinde etkin olarak aynı derecede kullanılabilir. Diazepamın daha düşük düzeyde sedasyon yaptığı unutulmamalıdır.

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Cite This Article

DEĞERLİ, V., KORKMAZ, T., TÜRKÇÜER, İ., ÇEVİK, A. A. (2022). Acil servise akut periferik vertigo ile başvuran hastalarda intravenöz diazepam, dimenhydrinate ve dipenhydramine tedavisinin etkinliğinin karşılaştırılması. Türkiye Acil Tıp Dergisi, Cilt: 7 - Sayı: 1, 10–17. https://ajindex.com/articles/626154

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