Journals / Türkiye Acil Tıp Dergisi / 2008 / Cilt: 8 - Sayı: 2

A fatal case after overdose of calcium channel blocker and literature review

Yüksek dozda kalsiyum kanal blokeri alımına bağlı ölüm olgusu ve literatürün gözden geçirilmesi

Pages
84–89
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, we aimed to evaluate the initial approach, complications, therapeutic options and clinical outcomes of serious amlodipine poisoning.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Besides their useful therapeutic actions, calcium channel blockers have also toxic effects causing adverse clinical outcomes.
📊
Key Findings & Data:A 19-year-old woman was admitted to our emergency department (ED) with complains of nausea and vomiting after 12 hours of ingesting high dose amlodipine.
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Conclusion & Impact:In this case report, we aimed to evaluate the initial approach, complications, therapeutic options and clinical outcomes of serious amlodipine poisoning.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Besides their useful therapeutic actions, calcium channel blockers have also toxic effects causing adverse clinical outcomes. A 19-year-old woman was admitted to our emergency department (ED) with complains of nausea and vomiting after 12 hours of ingesting high dose amlodipine. After administering gastric lavage, activated charcoal, calcium gluconate and glucose-insulin solutions in ED, she was admitted to the intensive care unit. Hypotension, liver and renal failure and then sepsis occurred during the intensive care follow-up. She died in the 20th day of the follow-up. In this case report, we aimed to evaluate the initial approach, complications, therapeutic options and clinical outcomes of serious amlodipine poisoning.

Özet

Kalsiyum kanal blokerleri, tedavi edici özelliklerinin yanı sıra, aşırı dozlarda ciddi klinik sonuçlara neden olan toksik etkilere sahiptirler. On dokuz yaşında kadın hasta yüksek dozda amlodipin aldıktan 12 saat sonra bulantı ve kusma yakınması ile acil servisimize getirildi. Hastaya acil serviste mide lavajı, aktif kömür, kalsiyum glukonat ve glukoz-insülin solüsyonu tedavisi uygulandı ve yoğun bakımda takibe alındı. Hasta takip altındayken ciddi hipotansiyon, böbrek yetmezliği, karaciğer yetmezliği ve sepsis gelişti. Uygulanan tedaviye rağmen hasta takibinin 20. gününde hayatını kaybetti. Bu sunumdaki amacımız, ciddi amlodipin zehirlenmesinin acil yaklaşım prensiplerini, komplikasyonlarını, tedavi seçeneklerini ve klinik sonuçlarını değerlendirmektir.

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Cite This Article

EDEN, A. O., BAYDIN, A., NURAL, M. S., YARDAN, T., DİLEK, A., GÖNÜLLÜ, H. (2022). A fatal case after overdose of calcium channel blocker and literature review. Türkiye Acil Tıp Dergisi, Cilt: 8 - Sayı: 2, 84–89. https://ajindex.com/articles/626104

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References (15)

  1. Hung YM, Olson KR. Acute amlodipine overdose treated by high dose intravenous calcium in a patient with severe renal insuff i c i e n c y. Clin Toxicol (Phila) 2007;45:301-3
  2. Kavalcı C, Durukan P, Özkan Y. Kalsiyum kanal blokeri zehirlenmesi: Olgu sunumu. Fırat Tıp Dergisi 2007; 21:85-6
  3. Kanagarajan K, Marraffa JM, Bouchard NC, Krishnan P, Hoffman RS, Stork CM. The use of vasopressin in the setting of recalcitrant hypotension due to calcium channel blocker overdose. Clin Toxicol (Phila) 2007;45:56-9
  4. Poggenborg RP, Videbaek L, Jacobsen IA. A case of amlodipine overdose. Basic Clin Pharmacol Toxicol 2006;99:209-12
  5. Beyaztafl FC, Aslan SM, Aslan BD. Olgu sunumu-Kalsiyum kanal blokerlerinin trombosit fonksiyonuna etkisi. T Klin J Med Sci 2001;21:121-3
  6. Harris NS. Case records of the Massachusetts General Hospital. Case 24-2006. A 40-year-old woman with hypotension after an overdose of amlodipine. N Engl J Med 2006;355:602-110
  7. Ross FD. Calcium channel blockers. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Howland MA, Hoffman RS, Nelson RS, editors. Goldfrank’s toxicologic emergencies. 7th ed. New York: McGraw Hill; 2002. p. 762–74
  8. Rasmussen L, Husted SE, Johnsen SP. Severe intoxication after an intentional overdose of amlodipine. Acta Anaesthesiol Scand 2003;47:1038-40
  9. Johansen SS, Genner J. Afatal case of amlodipine poisoning. J Clin Forensic Med 2003;10:169-72
  10. Sklerov JH, Levine B, Ingwersen KM, Aronica-Pollack PA, Fowler D. Two cases of fatal amlodipine overdose. J Anal Toxicol 2006;30:346-51
  11. Stanek EJ, Nelson CE, DeNofrio D. Amlodipine overdose. Ann Pharmacother 1997;31:853-6
  12. Cosbey SH, Carson DJ. A fatal case of amlodipine poisoning. J Anal Toxicol 1997;21:221-2
  13. Koch AR, Vogelaers DP, Decruyenaere JM, Callens B, Verstraete A, Buylaert WA.Fatal intoxication with amlodipine. J Toxicol Clin Toxicol 1995;33:253-6
  14. Levine M, Boyer EW, Pozner CN, Geib AJ, Thomsen T, Mick N, et al. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit Care Med 2007;35:2071-5
  15. Magdalan J, Antonczyk A, Kowalski K, Przewocki M, Kochman K, Wasylko- Smolarek M. Severe pulmonary complications of massive intoxication with calcium channel blockers and isosorbide mononitrate-a case report. [Article in Polish] Przegl Lek 2004;61:405-7. [Abstract] 16. Wood DM, Wright KD, Jones AL, Dargan PI. Metaraminol (Aramine) in the management of a significant amlodipine overdose. Hum Exp Toxico