Journals / Türkiye Acil Tıp Dergisi / 2011 / Cilt: 11 - Sayı: 4

Vinkristin tedavisi sonrası gelişen akut koroner sendrom

Acute coronary syndrome developed after vincristine administration

Pages
171–173
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present a case of acute coronary syndrome with complete atrio-ventricular (AV) block, developed after vincristine and doxorubicin chemotherapy in a patient with multiple myeloma and no cardiac history.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vincristine and doxorubicin are among the most effective chemotherapeutic agents used in the treatment of malignancies in combination per protocols.
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Key Findings & Data:However, these chemotherapeutic agents possess great risk for development of cardiotoxicity.
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Conclusion & Impact:We present a case of acute coronary syndrome with complete atrio-ventricular (AV) block, developed after vincristine and doxorubicin chemotherapy in a patient with multiple myeloma and no cardiac history.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Vincristine and doxorubicin are among the most effective chemotherapeutic agents used in the treatment of malignancies in combination per protocols. However, these chemotherapeutic agents possess great risk for development of cardiotoxicity. The most common manifestations of cardiotoxicity due to use of those chemotherapeutic agents are arrhythmias, systolic dysfunction, cardiomyopathy, pericardial injury and myocardial ischemia. We present a case of acute coronary syndrome with complete atrio-ventricular (AV) block, developed after vincristine and doxorubicin chemotherapy in a patient with multiple myeloma and no cardiac history.

Özet

Vinkristin ve doksorubisin kombinasyonu kemoterapi protokolü olarak malignitelerin tedavisinde kullanılan en etkili kemoterapötik ajanlardandır. Ancak, bu kemoterapötik ajanlar kardiyotoksisite gelişimi için oldukça risklidir. Bu kemoterapötik ajanlar nedeniyle en sık görülen toksik yan etkiler, aritmiler, sistolik disfonksiyon, kardiyomiyopati, perikardiyal yaralanma ve miyokard iskemisidir. Burada, kardiyak açıdan risk faktörü olmayan multipl myelom tanısı ile vinkristin ve doksorubisin kemoterapisi aldıktan sonra akut koroner sendrom ve atriyoventriküler (AV) blok gelişen bir olguyu sunuyoruz.

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Cite This Article

SARITAŞ, A., ÖZTÜRK, S., BALTACI, D., YAZICI, M., AYHAN, S. (2022). Vinkristin tedavisi sonrası gelişen akut koroner sendrom. Türkiye Acil Tıp Dergisi, Cilt: 11 - Sayı: 4, 171–173. https://ajindex.com/articles/626013

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References (10)

  1. Shan K, Lincoff AM, Young JB. Anthracycline-induced cardiotoxicity. Ann Intern Med 1996;125:47-58
  2. Steinberg JS, Cohen AJ, Wasserman AG, Cohen P, Ross AM. Acute arrhythmogenicity of doxorubicin administration. Cancer 1987;60:1213-8
  3. Jones RL, Swanton C, Ewer MS. Anthracycline cardiotoxicity. Expert Opin Drug Saf 2006;5:791-809
  4. Samuels BL, Vogelzang NJ, Kennedy BJ. Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy. Cancer Chemother Pharmacol 1987;19:253-6
  5. Calvo-Romero JM, Fernández-Soria-Pantoja R, Arrebola-Garcia JD, Gil-Cubero M. Ischemic heart disease associated with vincristine and doxorubicin chemotherapy. Ann Pharmacother 2001;35:1403-5
  6. Cargill RI, Boyter AC, Lipworth BJ. Reversible myocardial ischaemia following vincristine containing chemotherapy. Respir Med 1994;88:709-10
  7. Mikaelian I, Buness A, de Vera-Mudry MC, Kanwal C, Coluccio D, Rasmussen E, et al. Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs. Toxicol Sci 2010;117:144-51
  8. Lenaz L, Page JA. Cardiotoxicity of adriamycin and related anthracyclines. Cancer Treat Rev 1976;3:111-20
  9. Chatterjee K, Zhang J, Tao R, Honbo N, Karliner JS. Vincristine attenuates doxorubicin cardiotoxicity. Biochem Biophys Res Commun 2008;373:555-60
  10. Allal J, Becq-Giraudon B, Pouget-Abadie JF, Sudre Y, Barraine R. 2 new cases of myocardial infarction after injection of vincristine. [Article in French] Ann Cardiol Angeiol (Paris) 1984;33:469-70.