AI Summary & Key Takeaways
AI InsightWe found that the mean value of BNP for 102 patients without a history of heart failure who had hemodialysis was 570.5±594.5 pg/ml and did not have hemodialysis was found 280.8±471.4 pg/ml (p
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Abstract
Objectives There is no known biomarker to indicate the necessity of hemodialysis in patients with acute renal failure. We aimed to determine if plasma brain natriuretic peptide levels are useful to indicate the necessity of hemodi- alysis in patients who are diagnosed with acute renal failure with plasma creatinine levels equal to or greater than 2.5 mg/dl. Methods This study was designed as a prospective study in a tertiary emergency department. Patients older than 14 years old who had plasma creatinine levels equal to or greater than 2.5 mg/dl and had not undergone hemo- dialysis regularly were consecutively enrolled in the study. A nephrologist decided the necessity of hemodialysis. Results 124 patients participated in the study. 46 were evaluated as having an indication for hemodialysis. We found that the mean value of BNP for pa- tients who required hemodialysis was 646.6±731.9 pg/ml and those that did not have hemodialysis was 446.2±723.9 pg/ml (p=0.141). We found that the mean values of BNP, 1040.1±1123.1 pg/ml for patients who had hemodialysis and 207.8±203.6 pg/ml for patients who did not have he- modialysis, in a total of 19 patients with acute renal failure on chronic re- nal failure (p=0.04). We found that the mean value of BNP for 102 patients without a history of heart failure who had hemodialysis was 570.5±594.5 pg/ml and did not have hemodialysis was found 280.8±471.4 pg/ml (p
Özet
AmaçAkut böbrek yetersizliği hastalarında hemodiyaliz ihtiyacını öngörenbir biyobelirteç bulunmamaktadır. Çalışmamızda serum kreatinin de- ğeri 2.5 mg/dl ve üzerinde olan akut böbrek yetersizliği hastalarında serum beyin natriüretik peptit (BNP) düzeylerinin hemodiyaliz ihtiyacı- nı öngörmedeki kullanılabilirliğini araştırdık.Gereç ve Yöntem Çalışmamız üçüncü basamak bir acil serviste ileri dönük olarak yapıldı. Serum kreatinin değeri 2.5 mg/dl ve üzerinde olan ve rutin diyaliz prog-ramında bulunmayan 14 yaşın üzerindeki hastalar çalışmaya ardışık olarak alındı. Olguların hemodiyaliz ihtiyacı olup olmadığına nefrolojiuzmanı tarafından karar verildi.BulgularÇalışmaya 124 hasta alındı, 46’sına (%37.1) hemodiyaliz endikasyo-nu konuldu. Hemodiyalize alınan hastaların BNP düzey ortalaması646.6±731.9 pg/ml, hemodiyalize alınmayan hastaların ise 446.2±723.9pg/ml saptandı (p=0.141). Kronik böbrek yetersizliği üzerine akut böb-rek yetersizliği gelişen 19 hastada, hemodiyalize alınan ve alınmayanhastaların BNP düzey ortalaması sırasıyla 1040.1±1123.1 pg/ml ve 207.8±203.6 pg/ml olarak bulundu (p=0.04). Öncesinde kalp yetersiz-liği öyküsü olmayan 102 hastada hemodiyalize alınanların BNP düzeyortalaması 570.5±594.5 pg/ml, hemodiyalize alınmayan hastaların ise280.8±471.4 pg/ml olarak bulundu (p