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Journals / Türk Hijyen ve Deneysel Biyoloji Dergisi / 2022 / Cilt: 79 - Sayı: 2

The effects of tDCS on depression and anxiety disorders induced by Sub-Chronic stress

Sub-Kronik stresin neden olduğu depresyon ve anksiyete bozukluklarında tDAS’ın etkileri

Güven AKÇAY
Narin DERIN
Pages
267–278
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the stress group rats compared to the control group, there was a significant decrease in the locomotor activity levels (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Stress causes neuropsychiatric diseases such as depression and anxiety in the person by affecting emotions, opinions and behaviors.
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Key Findings & Data:Methods: 40 male Wistar rats weighing 290-310 g were divided into four groups as control, tDCS, stress and stress+tDCS.
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Conclusion & Impact:In the stress group rats compared to the control group, there was a significant decrease in the locomotor activity levels (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Stress causes neuropsychiatric diseases such as depression and anxiety in the person by affecting emotions, opinions and behaviors. In this study, the aim was to investigate the therapeutic effects of tDCS on depression and anxiety disorders that occur after subchronic stress. Methods: 40 male Wistar rats weighing 290-310 g were divided into four groups as control, tDCS, stress and stress+tDCS. Restraint stress was applied for 7 days (2 h/day) as a stress model. Rats in the tDCS and stress+tDCS groups were performed the stimulation of 1 mA anodal tDCS for three consecutive days from the 5th day of stress exposure. On the 7th day of the experiment, the anxiety and depression behaviors of the rats were evaluated with the open field test and the elevated plus maze test. Results: No significant changes were found in the locomotor activity, elevated plus maze test data between control and tDCS groups. In the stress group rats compared to the control group, there was a significant decrease in the locomotor activity levels (p

Özet

Amaç: Stres duygu, düşünce ve davranışları etkileyerek kişide depresyon, anksiyete gibi nöropsikiyatrik hastalıklara sebep olmaktadır. Bu çalışmada sub-kronik stres sonrası oluşan depresyon ve anksiyete bozukluklarına tDAS’ın terapötik etkilerinin incelenmesi amaçlanmıştır. Yöntem: 290-310 g ağırlığındaki 40 adet erkek Wistar sıçanlar kontrol, tDAS, stres ve stres+tDAS olmak üzere 4 gruba ayrılmıştır. Stres modeli olarak 7 gün boyunca günde 2 saat hareketsizlik stresi uygulanmıştır. tDAS ve stres+tDAS grubundaki sıçanlara stres maruziyetinin 5. gününden itibaren 3 gün boyunca 1 mA anodal tDAS uyarımı yapılmıştır. Deneyin 7. gününde sıçanların anksiyete ve depresyon davranışları açık alan testi ve yükseltilmiş artı labirent testi ile değerlendirilmiştir. Bulgular: Kontrol ve tDAS grupları arasında lokomotor aktivite, yükseltilmiş artı labirent testi verilerinde anlamlı değişim bulunmamıştır. Kontrol grubuna göre stres grubu sıçanların lokomotor aktivite düzeylerinde anlamlı azalma görülürken (p

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Cite This Article

AKÇAY, G., DERIN, N. (2022). The effects of tDCS on depression and anxiety disorders induced by Sub-Chronic stress. Türk Hijyen ve Deneysel Biyoloji Dergisi, Cilt: 79 - Sayı: 2, 267–278. https://ajindex.com/articles/624906

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References (16)

  1. Aguilera G, Rabadan-Diehl C, Nikodemova M. Regulation of pituitary corticotropin releasing hormone receptors. Peptides. 2001;22(5):769-74
  2. Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol. 2005;67:259-84
  3. Gronli J. Chronic mild stress-an animal model of depression [Doctoral Thesis]: University of Bergen; 2006
  4. Aysu Ş. Sıçanlarda kronik stresin empatiye etkilerinin araştırılması [Uzmanlık Tezi]: İzmir Kâtip Çelebi Üniversitesi 2020
  5. Smith SM, Vale WW. Autophagy deficiency contributes to diabetes progression. Nature Reviews Endocrinology. 2012;8(2):68
  6. Levine AB, Levine LM, Levine TB. Posttraumatic stress disorder and cardiometabolic disease. Cardiology. 2014;127(1):1-19
  7. Gregus A, Wintink AJ, Davis AC, Kalynchuk LE. Effect of repeated corticosterone injections and restraint stress on anxiety and depressionlike behavior in male rats. Behav Brain Res. 2005;156(1):105-14
  8. Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H, et al. Chronic administration of catechin decreases depression and anxiety-like behaviors in a rat model using chronic corticosterone injections. Biomol Ther (Seoul). 2013;21(4):313-22
  9. Thakare VN, Dhakane VD, Patel BM. Potential antidepressant-like activity of silymarin in the acute restraint stress in mice: Modulation of corticosterone and oxidative stress response in cerebral cortex and hippocampus. Pharmacol Rep. 2016;68(5):1020-7
  10. Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nat Neurosci. 2010;13(10):1161-9
  11. WHO. Depression 19.01.2021 [https://www.who. int/health-topics/depression]
  12. Cryan JF, Sweeney FF. The age of anxiety: role of animal models of anxiolytic action in drug discovery. Br J Pharmacol. 2011;164(4):1129-61
  13. Stagg CJ, Antal A, Nitsche MA. Physiology of Transcranial Direct Current Stimulation. J ECT. 2018;34(3):144-52
  14. Akcay G, Bahadır A. The Therapeutic Effects of Non-Invasive Transcranial Direct Current Stimulation (tDCS) in Experimental Models of Stroke. In: Chernopolskı PM, Shapekova NL, Ak B, eds. Research Advancements In Health Scıences. 1 ed. St. Klıment Ohrıdskı Unıversıty Press, 2021:28- 49
  15. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial direct current stimulation: a computer-based human model study. Neuroimage. 2007;35(3):1113-24
  16. Medeiros LF, de Souza IC, Vidor LP, de Souza A, Deitos A, Volz MS, et al. Neurobiological effects of transcranial direct current stimulation