Journals / Türk Hijyen ve Deneysel Biyoloji Dergisi / 2022 / Cilt: 79 - Sayı: 2

Evaluation of antinuclear antibodies in pregnant women with abortion with toxocariasis and toxoplasmosis in Iran

İran’da toksokariyaz ve toksoplazmozlu düşük yapan gebelerde antinükleer antikorların değerlendirilmesi

Pages
217–228
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These study findings indicated that there is a relatively high prevalence of T. gondii, Toxocara spp, and ANAs in pregnant women with abortion.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Toxoplasma gondii, Toxocara spp, and antinuclear antibodies (ANAs) have been reported as a cause of abortion.
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Key Findings & Data:To determine the prevalence rate of T. gondii, Toxocara spp, and ANAs in aborted women, and to investigate the association between infection and the number of the sociodemographic estimated risk factors.
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Conclusion & Impact:Conclusion: These study findings indicated that there is a relatively high prevalence of T. gondii, Toxocara spp, and ANAs in pregnant women with abortion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Toxoplasma gondii, Toxocara spp, and antinuclear antibodies (ANAs) have been reported as a cause of abortion. To determine the prevalence rate of T. gondii, Toxocara spp, and ANAs in aborted women, and to investigate the association between infection and the number of the sociodemographic estimated risk factors. Methods: This study was carried out in aborted women referred to the Qaem hospital in Mashhad city (Razavi Khorasan Province). Serum samples were examined for the presence of Antinuclear Antibody (IgG antibodies), anti-Toxoplasma gondii IgG and IgM antibodies, and IgG anti-toxocariasis spp antibodies by ELISA (Enzyme-Linked Immunosorbent Assay) kit. Data like contact with animals’ cats and dogs, age, and Type of cause of abortion (in most cases) were collected as risk factors for the prevalence of infection. Results: Out of 162 total samples of pregnant women were collected, 28% were positive for T. gondii IgG, and 2% IgM, anti-Toxocara spp IgG antibodies were detected in 12% and Antinuclear antibodies detected in 31% in pregnant women with abortion. Co-infection of T. gondii and Toxocara spp detected in 9%, also ANAs detected in cases with T. gondii in 24% and 10% with Toxocara spp. ANAs showed positivity with co-infection of T. gondii and Toxocara spp in 8%. This study showed a significant association between infection of each T. gondii, Toxocara spp, and ANAs with age and animal contact such as cats and dogs. Conclusion: These study findings indicated that there is a relatively high prevalence of T. gondii, Toxocara spp, and ANAs in pregnant women with abortion. The coexistence of two agents or of one with ANAs increases the risk of abortion. All of them showed association with age and contact with domestic animals like cats and dogs.

Özet

Amaç: Toxoplasma gondii, Toxocara spp ve antinükleer antikorlar (ANA’lar) düşük nedeni olarak rapor edilmiştir. Bu çalışmanın amacı düşük yapan kadınlarda T. gondii, Toxocara spp ve ANA prevalans oranını belirlemek ve enfeksiyon ile sosyodemografik olarak tahmin edilen risk faktörlerinin sayısı arasındaki ilişkiyi araştırmaktır. Yöntem: Bu çalışma, Meşhed şehrinde (Razavi Horasan Eyaleti) Qaem hastanesine sevk edilen düşük yapan kadınlarda gerçekleştirildi. Serum numuneleri ELISA (Enzyme-Linked Immunosorbent Assay) kiti ile Antinükleer Antikor (IgG antikorları), anti-Toxoplasma gondii IgG ve IgM antikorları ve IgG anti-toksokariazis spp antikorlarının varlığı açısından incelendi. Kedi ve köpek gibi hayvanlarla temas, yaş ve düşük nedeni (çoğu vakada) gibi veriler enfeksiyon prevalansı için risk faktörleri olarak toplandı. Bulgular: Toplam 162 gebeden alınan örneklerin %28’inde T. gondii IgG, %2’sinde IgM pozitifliği, %12’sinde anti-Toxocara spp IgG antikorları ve abortus yapan gebelerin % 31’inde Antinükleer antikorlar tespit edildi. Olguların %9’unda T. gondii ve Toxocara türlerinin koenfeksiyonu, T. gondii olgularında %24 ve Toxocara spp. olgularında %10 oranında ANA’lar tespit edildi. T. gondii ve Toxocara türlerinin ko-enfeksiyonunda ise ANA pozitifliği %8 oranında bulundu. Bu çalışma, hem T. gondii, hem Toxocara spp. enfeksiyonları ve hem de ANA’ların, olguların yaşı ve kedi, köpek gibi hayvanlarla teması arasında önemli bir ilişki olduğunu göstermiştir. Sonuç: Bu çalışma bulguları, düşük yapan gebe kadınlarda T. gondii, Toxocara spp. ve ANA’ların prevalansının nispeten yüksek olduğunu göstermiştir. İki ajanın beraber veya her birinin ANA’larla birlikte bulunması düşük riskini artırır. Bunların hepsinin olguların yaşı ve kedi, köpek gibi evcil hayvanlarla temasıyla ilişkili olduğunu gösterdi.

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Cite This Article

SOHRABI, Z., RAISSI, V., ALIZADEH, G., ETEMADI, S., RAIESI, O., BAGHERPOOR, M. R., SAMANI, Z. B., PARANDİN, F., HASHEMIBAGHI, Z., IBRAHIM, A. (2022). Evaluation of antinuclear antibodies in pregnant women with abortion with toxocariasis and toxoplasmosis in Iran. Türk Hijyen ve Deneysel Biyoloji Dergisi, Cilt: 79 - Sayı: 2, 217–228. https://ajindex.com/articles/624899

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