Evaluation of plasma C-reactive protein and D-dimer levels of coal miners

CRP and DD levels were studied in blood samples of both groups CRP and DD levels were found to be significantly higher in study group than in control group (p

📌 3 Key Takeaways

🎯

Objective & Hypothesis:This study was planned to investigate alterations of D-Dimer (DD), which is accepted as an indicator of procoagulant system, and C-reactive protein (CRP), which is accepted as an indicator inlammation in coal miners who were exposed to coal dust.

📊

Key Findings & Data:Coal dust increases fibroblast proliferation, extracellular matrix synthesis and secretion of proinflammatory factors.

💡

Conclusion & Impact:CRP and DD levels were studied in blood samples of both groups CRP and DD levels were found to be significantly higher in study group than in control group (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

This study was planned to investigate alterations of D-Dimer (DD), which is accepted as an indicator of procoagulant system, and C-reactive protein (CRP), which is accepted as an indicator inlammation in coal miners who were exposed to coal dust. Coal dust increases fibroblast proliferation, extracellular matrix synthesis and secretion of proinflammatory factors. So the effect of coal dust is not restricted to the lungs, but it also affects various systems. Especially its IL6 and TNF-α increasing effect makes us think that coal dust may cause inflammation and alterations in hemodynamic system. In this study, 34 males who had been working in coal mines were taken as study group and 32 males who had not been working in coal mines were taken as control group. CRP and DD levels were studied in blood samples of both groups CRP and DD levels were found to be significantly higher in study group than in control group (p

Özet

Bu çalışma, kömür tozuna maruz kalan işçilerde prokoagulan sistemin bir göstergesi olarak kullanılan D-Dimer (DD) ile bir inflamasyon belirteci olarak kabul edilen C-reaktif protein (CRP) düzeyindeki değişiklikleri araştırmak amacı ile planlandı. Kömür tozu, fibroblast proliferasyonunu, ekstrasellüler matriks sentezini ve proinflamatuar faktörlerin sekresyonunu artırmaktadır. Bu nedenle kömür tozunun etkisi sadece akciğer dokusu ile sınırlı kalmamakta, birçok sistemi de etkilemektedir. Özellikle IL-6 ve TNF-α miktarında artışa neden olması, inflamasyon ve hemostatik sistemde değişikliğe neden olabileceğini düşündürmektedir. Çalışmada kömür madeninde çalışan 34 erkek çalışma grubu olarak ve kömür madeninde çalışmayan 32 erkek kontrol grubu olarak alındı. Her iki gruptan alınan kan örneklerinden CRP ve DD düzeyleri çalışıldı. Çalışma grubunda plazma CRP ve DD düzeyleri kontrol grubundan anlamlı derecede yüksek bulundu (p

🔖

Cite This Article

PINAR, T., ARMUTCU, F., ÜNALACAK, M., ÖZEREN, A., GÜREL, A., AYDIN, M. (2022). Evaluation of plasma C-reactive protein and D-dimer levels of coal miners. Türk Hematoloji Onkoloji Dergisi, Cilt: 14 - Sayı: 2, 86–89. https://ajindex.com/articles/624740

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (15)

Green FHY, Vallyathan V. Coal workers' pneumoconiosis and pneumoconiosis due to other carbonaceous duts. In A. Churg and F.H.Y. Green, editors. Pathology of Occupational Lung Disease. Williams Wilkins, Philadephia. 1998:129-208
Schins, RPF, and PJA. Borm. Mechanisms of mediatorys in coal dust induced toxicity:a review. Ann Occup Hyg 43:7-33, 1999
Bounameaux H, de Moerloose P, Perrier A, Reber G. Plasma measurement of D-dimer as diagnostic aid in suspected venousthromboembolism: an overview. Thromb Haemost 71:1-6, 1994
Brill-Edwards P, Lee A. D-dimer testing in the diagnosis of acute venous thromboembolism. Thromb Haemost 82:688-694, 1999
Wakai A, Gleeson A, Winter D. Role of fibrin D-dimer testing in emergency medicine. Emerg Med J 20:319-25, 2003
Tardy B, Tardy-Poncet B, Viallon A, et al. D- dimer levels in patients with suspected acute cerebral venous thrombosis. Am J Med 113:238- 241,2002
Woodward M, Rumley A, Lowe GD, Tunstall-Pedoe H. C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease. Br J Haematol 122:135-141, 2003
Albert MA, GlynnRJ, Ridker PM. Plasma Concentration of C-Reactive Protein and the Calculated Framingham Coronary Heart Disease Risk Score. Circulation 108:161-165,2003
Reiter M, Bucek RA, Koca N, et al. Deep vein thrombosis and systemic inflammatory response: a pilot trial. Wien Klin Wochenschr 115:111-114,2003
Bucek RA, Reiter M, Quehenberger P, Minar E. C-reactive protein in the diagnosis of deep vein thrombosis. Br J Haematol 119:385-389, 2002
Zhang Q, Huang X. Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species. J Biosci 28:95-100, 2003
Zhai R, Liu G, Ge X, et al. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and their soluble receptors in coal workers' pneumoconiosis. Respir Med 96:829-834, 2002
Lin ZQ, Kondo T, Ishida Y, et al. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 73:713- 721,2003
Woodward M, Rumley A, Tunstall-Pedoe H, Lowe GD. Associations of blood rheology and interleukin-6 with cardiovascular risk factors and prevalent cardiovascular disease. Br J Haematol 104:246-257, 1999
McCarty MF. Reduction of serum C-reactive protein by statin therapy may reflect decreased isoprenylation of Rac-1, a med