Journals / Türk Girişimsel Kardiyoloji Derg. / 2009 / Cilt: 13 - Sayı: 1

Results of thrombolytic treatment in patients with ST elevation myocardial infarction

ST yükselmeli akut miyokard infarktüsü tanısı almış hastalardaki trombolitik tedavi sonuçlarımız

Pages
1–5
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore fibrinolytic therapy is an effective treatment of choice in STEMI which is easy to perform in anywhere and anytime

📌 3 Key Takeaways

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Objective & Hypothesis:Restoration of full antegrade flow in the ST elevation myocardial infarction by percutaneus coronary intervention (PCI) is the principal treatment of choice.
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Key Findings & Data:However an experienced team is mandatory which is available 24 hour a day.
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Conclusion & Impact:Therefore fibrinolytic therapy is an effective treatment of choice in STEMI which is easy to perform in anywhere and anytime
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Restoration of full antegrade flow in the ST elevation myocardial infarction by percutaneus coronary intervention (PCI) is the principal treatment of choice. However an experienced team is mandatory which is available 24 hour a day. Therefore reperfusion with thrombolytic treatment is the most common reperfusion of choice worldwide. Limited number of data about usage of thrombolytic treatment in STEMI is available in our country. The objective of current study is to evaluate the results of trombolytic treatment retrospectively and to report it.Three hundred twenty-one patients diagnosed as STEMI and treated with fibrinolytic therapy at Rize State hospital between 1999-2007 years were enrolled in the current study. World Health Organization's criterias was used in diagnosis of STEMI. Demographic characteristics of patients, type of the STEMI, effects and side effects of the therapy were evaluated retrospectively.The mean age of 321 patients with STEMI (291 male and 30 female) was 57,35 years. Average age of male and female patients was 56,45±9,09, 66,10±11,20 respectively. The localization STEMI was anterior in 169 patients, inferior in 139 patients and other localizations in 17 patients. Streptokinase was administered in 199 patients and tissue plasminogen activator (tPA) in 122. 258 patients (80%) had successful outcome and remaining 63 patients (20%) had poor outcome.Although primary PCI is superior to fibrinolytic therapy in patients with STEMI, there are lots of limitations in clinical practice. Therefore fibrinolytic therapy is an effective treatment of choice in STEMI which is easy to perform in anywhere and anytime

Özet

ST yükselmeli akut miyokard infarktüsünün (STEMI) en önemli tedavisi primer perkütan koroner girişim (PKG) ile tıkalı olan damarda reperfüzyonun sağlanmasıdır. Fakat bunun için 24 saa tecrübeli bir ekibe ihtiyaç vardır. Bu nedenle dünyada hala trombolitik tedavi ile reperfüzyon en yaygın uygulanan reperfüzyon tedavisidir. Ülkemizde STEMI'li olgularda uygulanan trombolitik tedavi ile ilgili oldukça sınırlı sayıda veri vardır. Bu çalışmadaki amacımız yaklaşık 8 yıllık bir dönemde hastanemizde uygulanan trombolitik tedavi sonuçlarını retrospektif olarak inceleyip bildirmektir. Çalışmaya 1999-2007 yılları arasında hastanemiz acil servisine başvurup STEMI tanısı konularak yatırılan ve fibrinolitik tedavi uygulanan 321 hasta alındı. STEMI tanısında Dünya Sağlık Örgütü kriterleri kullanıldı. Hastaların demografik özellikleri, STEMI'nin lokalizasyonu, trombolitik tedavinin etkinliği ve yan etkileri retrospektif olarak gözden geçirildi.Çalışmaya alınan STEMI'lı 321 hastanın (291'i erkek, 30'u kadın) yaş ortalaması 57,35 yıldı. Erkeklerin yaş ortalaması 56,45±9,09 yıl, kadınlarinki ise 66,10±11,2 yıldı. STEMI lokalizasyonu 165 (%51) hastada anterior, 139 (%43) hastada inferiyor ve 17 (%5) hastada da diğer bölgelerdeydi. 199 (%62) hastada trombolitik ilaç olarak streptokinaz uygulanırken, 122 (%38) hastada doku plazminojen aktivatörü (tPA) kullanıldı. 258 (%80) hastada uygu- lanan reperfüzyon tedavisi başarılı kabul edilirken, 63 (%20) hastada ise başarısız olarak kabul edildi.STEMI'de primer PKG fibrinolitik tedaviye üstün olmasına rağmen, uygulanmasında pek çok kısıtlamalar vardır. Dolayısıyla fibrinolitik tedavi kolaylıkla her zaman ve her yerde uygulanabilir etkili ve önemli bir tedavi alternatifidir.

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Cite This Article

BÜYÜKKAYA, E., BOSTAN, M., KAHVECİ, G., BOZKURT, E. (2022). Results of thrombolytic treatment in patients with ST elevation myocardial infarction. Türk Girişimsel Kardiyoloji Derg., Cilt: 13 - Sayı: 1, 1–5. https://ajindex.com/articles/624469

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References (11)

  1. Bhatt DL, Steg PG, Ohman EM, Rother J, Wilson PW. International prevalance, recognition and treatment of cardiovascular risk factors in out patients with atherothrombosis. JAMA 2006; 295:180-89
  2. Wasserman EJ, Shipley NM. Atherothrombosis in acute coronary syndromes: Mechanisms, markers, and mediators of vulnerability. Mt Sinai J Med 2006;73:431-39
  3. Antman EM, Anbe DT, Armstrong PW. ACC/AHA Guidelines for the management of patients with ST-Elevation Myocardial Infarction: A report of American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial İnfarction). American College of Cardiology Web Site, 2006.(www.acc.org/clinical/guidelines/stemi/index.pdf). Accessed 6/21/06
  4. Lueper RV, Apple FS, Christenson RH. Case definition for acute coronary heart disease in epidemiology and clinical research studies: A statement from the AHA Council on Epidemiology and Prevention: AHA Statistic committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and National Heart, Lung, and Blood Institute. Circulation 2003;108:2543-49
  5. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989;80:1049-62
  6. Pasceri V, Andreotti F, Maseri A. Clinical markers of trombolytic success. Eur Heart J 1996;17:35-41
  7. Morrison LJ, Verbeek PR, Macdonald AC, Sawadsky BV, Cook DJ. Mortality and prehospital thrombolysis for acute myocardial infarction: A meta-analysis. JAMA 2000;283:2686-92
  8. Bonnefoy E, Lapostello F, Leizorovicz A, Steg G, McFadden EP, Dubien PY. Primary angioplasty versus prehospital fibrinolysis in acute myocardial infacrtion: a randomised study. Lancet 2002;360:825-29
  9. Steg PG, Bonnefoy E, Chabaud S, Lapostello F, Dubien PY, Cristofini P. Impact of time to treatment on mortality after prehospital fibrinolysis oprimary angiopalsty: data from the CAPTIM ran- domised clinical trial. Circulation 2003;108:2851-56
  10. Franzosi MG, Santoro E, De Vita C, Geraci E, Lotto A, Maggioni AP, et al. Ten-year follow-up of the megatrial testing thrombolytic therapy in patients with acute myocardial infarction: results of the Gruppo Italiano per lo Studio della Soppravvivenza nell'Infarto-1 study. The GISSI Investigators. Circulation 1998;98:2659-65
  11. Boersma E, Mercado N, Poldermans D