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Journals / Türk Girişimsel Kardiyoloji Derg. / 2010 / Cilt: 14 - Sayı: 3

Association of serum paraoxanase activity, oxidative stress markers and severe LMCA lesions

Serum paroksonaz aktivitesi ve oksidatif stres belirteçleri ile ciddi LMCA lezyonlarının ilişkisi

İbrahim Halil ALTIPARMAK
Ali YILDIZ
Recep DEMİRBAĞ
Abdullah TAŞKIN
Nurten AKSOY
Yusuf SEZEN
Mehmet Memduh BAŞ
Asuman Biçer YEŞİLAY
Mustafa POLAT
Ünal GÜNTEKİN
Zekeriya KÜÇÜKDURMAZ
Pages
97–102
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Lowest and highest SPA was detected in the LMCA+ and in the NCA groups (ANOVA p=0.001) respectively.Findings of the present study suggest that decreased SPA and increased oxidative stress might be associated with the presence of LMCA stenosis beyond the presence of CAD.

📌 3 Key Takeaways

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Objective & Hypothesis:Patients with significant left main coronary artery (LMCA) stenosis have a special significance since LMCA supplies wide myocardial area and LMCA stenosis can accompany multi-vessel disease and accordingly appropriate primary and secondary therapeutic options should be identified and applied ultimately.
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Key Findings & Data:Consequently the aim of this study is to investigate serum oxidative parameters and SPA in patients with severe LMCA lesions, in coronary artery disease (CAD) patients without LMCA stenosis and in cases with normal coronary artery (NCA).Twenty-five patients with >50% LMCA stenosis (LMCA+ group), 25 CAD patients without LMCA stenosis (LMCA- group), and 25 patients with NCA (NCA group) were included.
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Conclusion & Impact:Lowest and highest SPA was detected in the LMCA+ and in the NCA groups (ANOVA p=0.001) respectively.Findings of the present study suggest that decreased SPA and increased oxidative stress might be associated with the presence of LMCA stenosis beyond the presence of CAD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Patients with significant left main coronary artery (LMCA) stenosis have a special significance since LMCA supplies wide myocardial area and LMCA stenosis can accompany multi-vessel disease and accordingly appropriate primary and secondary therapeutic options should be identified and applied ultimately. The association of serum oxidative parameters and serum paraoxonase activity (SPA) with the presence of LMCA stenosis is unknown. Consequently the aim of this study is to investigate serum oxidative parameters and SPA in patients with severe LMCA lesions, in coronary artery disease (CAD) patients without LMCA stenosis and in cases with normal coronary artery (NCA).Twenty-five patients with >50% LMCA stenosis (LMCA+ group), 25 CAD patients without LMCA stenosis (LMCA- group), and 25 patients with NCA (NCA group) were included. Height, weight and blood pressure of all subjects were measured with standard methods. Severity of CAD was evaluated with Gensini score in LMCA+ and LMCA- groups. Total antioxidant status (TAS), total oxidant status (TOS), and SPA were studied by calorimetric methods from serum samples at the end of the study. Biochemical parameters including lipid profile, serum glucose, urea and creatinine were recorded. Groups were analyzed with one way ANOVA and chi square tests with regard to parametric and nonparametric variables, respectively.TAS was similar among groups (ANOVA p=0.05). The highest TOS was in the LMCA+ group whereas the owest TOS was in the NCA group (ANOVA p=0.027). The highest OSI was in the LMCA+ group and there was statistically significant difference between groups with regard to OSI (ANOVA p=0.008). Lowest and highest SPA was detected in the LMCA+ and in the NCA groups (ANOVA p=0.001) respectively.Findings of the present study suggest that decreased SPA and increased oxidative stress might be associated with the presence of LMCA stenosis beyond the presence of CAD.

Özet

Ciddi sol ana koroner arter (LMCA) darlığı risk altındaki miyokart alanının genişliği ve beraberinde bulunabilecek çoklu damar hastalığı nedeni ile özel bir öneme sahip olup uygun primer ve sekonder tedavi modalitelerinin belirlenip uygulanması özel önem arz eder. LMCA darlığının gelişimi ile serum oksidatif parametrelerinin ve serum paroksonaz aktivitesinin (SPA) etkisi bilimemektedir. Bu çalışmadaki amacımız ciddi LMCA lezyonu olan koroner arter hastalığı (KAH) olguları ile LMCA lezyonu olmayan KAH ve normal koroner arter (NKA)'e sahip bireyleri serum oksidatif stres parametreleri ve SPA düzeyleri yönünden karşılaştırmaktır. Çalışmaya LMCA'sında %50 ve üzeri darlık olan 25 (LMCA+ grup), LMCA lezyonu olmayan ancak KAH'ı bulunan 25 hasta (LMCA- grup) ile koroner arterleri normal olan 25 birey (NKA grubu) alındı. Boy, kilo, kan basıncı standart yöntemlerle ölçüldü. LMCA+ ve LMCA- gruplarında koroner arter hastalığı yaygınlığı Gensini skuoru ile değerlendirildi. Total antioksidan durum (TAS), total oksidan durum (TOS) ve SPA için açlık serum örnekleri alınarak çalışma sonunda kalorimetrik yöntemlerle çalışıldı. Hastaların lipit profili, kan şekeri, üre ve kreatînin düzeyleri kaydedildi. Üç grup arasında parametrik değişkenler tek yönlü ANOVA testi ile analiz edilirken parametrik olmayan değişkenler ki-kare testi ile analiz edildi. Gruplar arasında TAS benzerdi (ANOVA p=0,05). TOS en yüksek LMCA+ grupta en düşük olarak NKA grubunda (ANOVA p=0,027) saptandı. OSI en yüksek LMCA+ grupta en düşük NKA grubunda olup gruplar arasında istatistiksel olarak anlamlı fark vardı (ANOVA p=0,008). En düşük SPA değeri LMCA+ grupta saptanırken en yüksek SPA değeri ise NKA grubunda saptandı (ANOVA p=0,001). Bu çalışmanın sonuçları artmış oksidatif stres ve azalmış paroksonaz aktivitesinin koroner arter hastalığı gelişimi yanında daha ciddi bulgularla seyreden LMCA darlığının varlığıyla ilişkili olabileceğini düşündürmektedir

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Cite This Article

ALTIPARMAK, İ. H., YILDIZ, A., DEMİRBAĞ, R., TAŞKIN, A., AKSOY, N., SEZEN, Y., BAŞ, M. M., YEŞİLAY, A. B., POLAT, M., GÜNTEKİN, Ü., KÜÇÜKDURMAZ, Z. (2022). Association of serum paraoxanase activity, oxidative stress markers and severe LMCA lesions. Türk Girişimsel Kardiyoloji Derg., Cilt: 14 - Sayı: 3, 97–102. https://ajindex.com/articles/624444

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