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Journals / Türk Geriatri Dergisi / 2004 / Cilt: 7 - Sayı: 2

The effects of short term hormone replacement therapy on serum nitric oxide levels and lipid profile in postmenopausal women

Postmenapozal kadınlarda kısa süreli hormon replasman tedavisinin serum nitrik oksid düzeyleri ve lipid profiline etkileri

Sara HABİF
Ayşalı YILMAZ
Ceyda KABAROĞLU
Kemal ÖZTEKİN
Oya BAYINDIR
Dilek ÖZMEN
Pages
66–69
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Before and after treatment values were compared with paired Student’s t test and p

📌 3 Key Takeaways

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Objective & Hypothesis:Hormone replacement therapy (HRT) used in the treatment of vasomotor and vaginal symptoms seen in the postmenopausal women, has shown to have beneficial effects in osteoporosis and atherosclerosis and also, on changes in cognitive function and Alzheimer’s disease observed in the elderly women.
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Key Findings & Data:To evaluate the effect of short term HRT on nitric oxide levels and lipid profile in healthy postmenopausal women, 20 subjects were given estradiol-17-valerat and cyproterone acetate in a combined fashion.
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Conclusion & Impact:Before and after treatment values were compared with paired Student’s t test and p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hormone replacement therapy (HRT) used in the treatment of vasomotor and vaginal symptoms seen in the postmenopausal women, has shown to have beneficial effects in osteoporosis and atherosclerosis and also, on changes in cognitive function and Alzheimer’s disease observed in the elderly women. Nitric oxide is an endothelial-derived vasodilation factor, posing an important role in the maintenance of endothelial wall, and in the protective mechanisms of endothelial injury. Hormone replacement therapy is thought to have a cardioprotective role in the post-menopausal women via endothelial derived nitric oxide and by exerting changes in the lipid profile. To evaluate the effect of short term HRT on nitric oxide levels and lipid profile in healthy postmenopausal women, 20 subjects were given estradiol-17-valerat and cyproterone acetate in a combined fashion. Before and after treatment values were compared with paired Student’s t test and p

Özet

Menapozun yol açtığı vazomotor ve vajinal semptomların tedavisinde kullanılan hormon replasman tedavisinin (HRT), ileri yaşla birlikte görülen kognitif fonksiyon değişiklikleri ve Alzheimer hastalığının yanı sıra, postmenapozal süreçte izlenen ateroskleroz ve osteoporoz üzerine de olumlu etkilerinden bahsedilmektedir. Nitrik oksid , vaskuler bütünlüğün sağlanmasında ve hasarlanmadan korunmada önemli rol oynayan endotel kökenli bir damar gevşeticidir. Hormon replasman tedavisinin lipid profili ve damar endoteli üzerinde nitrik oksid aracılı olumlu etkileri, uygulamanın postmenapozal kadınları kardiyovasküler hastalıklardan korumada önemli olabileceğini düşündürtmektedir. Çalışmada 20 postmenapozal kadında östradiol-17-valerat ile siproteron asetat kombine HRT tedavisinin kısa dönemde, serum nitrik oksid düzeylerine ve lipid profiline etkisi araştırılmıştır. Replasman öncesi bazal ve HRT sonrası 3.ayda alınan örneklere ait ölçümler eşli Student’s t-testi ile karşılaştırılmış, p

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Cite This Article

HABİF, S., YILMAZ, A., KABAROĞLU, C., ÖZTEKİN, K., BAYINDIR, O., ÖZMEN, D. (2022). The effects of short term hormone replacement therapy on serum nitric oxide levels and lipid profile in postmenopausal women. Türk Geriatri Dergisi, Cilt: 7 - Sayı: 2, 66–69. https://ajindex.com/articles/624360

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