Journals / Türk Geriatri Dergisi / 2006 / Cilt: 9 - Sayı: 4

Is mild cognitive impairment an early Alzheimer disease?

Hafif kognitif etkilenme erken dönem Alzheimer hastalığı mıdır?

Pages
240–249
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

But who exibit some form of cognitive impairment.We discussed in this paper clinical, neuroimaging, biomarkers, neuropathological property and therapy of the MCI in the current literature are consistent with this position.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mild cognitive impairment (MCI) is a boundary or transitional state between normal aging and early dementia particularly Alzheimer's disease (AD) characterised by memory impairment or other cognitive deficits have been reported but preserved activities of daily living.
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Key Findings & Data:MCI as a possible prodromal stage of dementia.
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Conclusion & Impact:But who exibit some form of cognitive impairment.We discussed in this paper clinical, neuroimaging, biomarkers, neuropathological property and therapy of the MCI in the current literature are consistent with this position.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Mild cognitive impairment (MCI) is a boundary or transitional state between normal aging and early dementia particularly Alzheimer's disease (AD) characterised by memory impairment or other cognitive deficits have been reported but preserved activities of daily living. MCI as a possible prodromal stage of dementia. Little is known about factors that predict transition from MCI to dementia. This clinical state construct was developed to characterize older adults who were neiter cognitively normal nor overtly demented. It is a term generally referring to persons who do not fulfil criteria for AD or dementia.It is not an established clinical diagnosis but a concept for which different criteria have been proposed and also modified over time. But who exibit some form of cognitive impairment.We discussed in this paper clinical, neuroimaging, biomarkers, neuropathological property and therapy of the MCI in the current literature are consistent with this position.

Özet

Hafif kognitif etkilenme (HKE) normal yaşlanma ve erken demans özellikle Alzheimer hastalığı (AH) için hafızada azalma veya diğer kognitif defisitlerle karekterize, ancak günlük yaşam aktivitesinin korunduğu sınırda veya geçiş dönemi olan bir durum olarak belirtilmiştir. Demansın prodromal bir dönemi gibidir. Demansa dönüş faktörleri konusunda çok az şey bilinir. Bu yaşlılarda kognitif olarak normal olmayan ve açık bir şekilde demansın olmadığı AH veya diğer demans klinik kriterlerini tam doldurmayan klinik durumdur.Klinik tanısı tam olarak oturmamakla birlikte, zamanla değişen farklı kriterler ve kognitif azalmanın bazı formları tanımlanmıştır.Bu yazıda HKE'nin klinik, nörogörüntüleme, biyolojik belirleyiciler, nöropatolojik özellikleri ve tedavisi bu konudaki son literatür gözden geçirilerek incelenmiştir.

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Cite This Article

KARAMAN, Y. (2022). Is mild cognitive impairment an early Alzheimer disease?. Türk Geriatri Dergisi, Cilt: 9 - Sayı: 4, 240–249. https://ajindex.com/articles/624307

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References (12)

  1. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, Dekosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence- based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1133-1142.
  2. Chen P, Ratcliff G, Belle SH, Cauley JA, Dekosky ST, Ganguli M. Patterns of decline in pre-symptomatic Alzheimer's Disease: a prospective community study. Arch Gen Psychiatr 2001;58:853-858.
  3. Daly E, Zaitchik D, Copeland M, Schmahmann J, Gunther J, Albert M. Predicting conversion to Alzheimer disease using standardized clinical information. Arch Neurol 2000; 57:675-680. Petersen RC. Normal aging, mild cognitive impairment,and early Alzheimer's disease. Neurologist 1995; 1:326-344.
  4. Morris JC, Storandt M, Miller JP, et al: Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001;58:397-405.
  5. Geslani DM, Tierney MC, Herrmann N. Mild cognitive impair ment: an operation rate to Alzheimer's disease. Dement Geriatr Cogn Disord 2005; 19:383-389.
  6. Elias MF, Beiseries A, Wolf PA, Au R, White RF, D'Agostino RB. The preclinical phase of Alzheimer's disease: a 22-year prospective study of the Framingham cohort. Arch Neurol 2000; 57:808-813. 24. Flicker C, Ferris S, Reisberg B. Mild cognitive impairment in the elderly: Predictors of dementia. Neurology 1991;41:1006-1009.
  7. Johansson B, Zarit SH. Early cognitive markers of the incidence of dementia and mortality: a longitudinal study of the oldest old. Int J Geriatr Psychiatry 1997; 12:53-59.
  8. Morris JC, Cummings J. Mild cognitive impairment (MCI) rep resents early-stage Alzheimer's disease. J Alz Dis 2005;7:235-239.
  9. Riemenschneider M, Lautenschlager N, Wagenpfeil S, Diehl J, Drzezga A, Kurz A. Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer's disease in subjectswith mild cognitive impairment. Arch Neurol 2002;59:1729-1734.
  10. Smith CD, Snowdon DA, Wang H, Markesbery WR. White matter volumes and periventricular white matter hyperintensities in aging and dementia. Neurology 2000; 54:838-842.
  11. Wolf H, Jelic V, Gertz H-J, Nordberg A, Julin P, Wahlund L O. A critical discussion of the role of neuroimaging in mild cognitive impairment. Acta Neurol Scand 2003: 107:52-76 30. Levy R. Ageing-Associated Cognitive Decline Working Party of the International Psychogeriatric Association in Collaboration with the Word Health Organization. Int Psychogeriatric 1994;6:63-68.
  12. Bozoki A, Giordani B, Heidebrink JL, B