Journals / Türk Geriatri Dergisi / 2008 / Cilt: 11 - Sayı: 4

A case of tenoxicam induced generalized (multifocal) bullous fixed drug eruption

Tenoksikam ile gelişen bir generalize (multifokal) büllöz fiks ilaç erüpsiyonu olgusu

Pages
200–203
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present the case because of its rarity to emphasize the clinical importance of the differential diagnosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Fixed drug eruption is a common cutaneus reaction characterized by the formation of localized erytema, hyperpigmentation and blisters that recur at the same cutaneous site or sites each time when the drug is ingested.
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Key Findings & Data:The most frequently causative agents are various antibiotics, analgesic/ anti-inflammatory drugs, barbiturates, laxatives that contain phenolphthalein, metronidazole, oral contraceptives and quinine.
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Conclusion & Impact:We present the case because of its rarity to emphasize the clinical importance of the differential diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Fixed drug eruption is a common cutaneus reaction characterized by the formation of localized erytema, hyperpigmentation and blisters that recur at the same cutaneous site or sites each time when the drug is ingested. Rarely it can be disseminated. Fixed drug eruption has been reported with many drugs. The most frequently causative agents are various antibiotics, analgesic/ anti-inflammatory drugs, barbiturates, laxatives that contain phenolphthalein, metronidazole, oral contraceptives and quinine. Herein, we report a case of a generalized bullous fixed drug eruption developing in a 61-year-old female patient after using a suppository containing tenoxicam for the purpose of analgesia. We present the case because of its rarity to emphasize the clinical importance of the differential diagnosis.

Özet

Fiks ilaç erüpsiyonu; oldukça sık görülen, sebep olan ilacın her alımından sonra, genellikle vücudun aynı bölgesinde ya da bölgelerinde ortaya çıkan, lokalize eritem, hiperpigmentasyon ve büllerle seyredebilen bir deri hastalığıdır. Nadiren dissemine lezyonlara da rastlanmaktadır. Bir çok ilaca bağlı olarak fiks ilaç erüpsiyonu gelişebildiği bildirilmektedir. Çeşitli antibiyotikler, ağrı kesici/ antiinflamatuvar ilaçlar, barbitüratlar, fenolftalein içeren laksatifler, metronidazol, oral kontraseptifler ve kinin bu konuda suçlanan başlıca ilaçlardır. Bu olguda, ağrı kesici olarak tenoksikam içeren bir supozituvar kullanımından sonra vücudunda generalize büllöz fiks ilaç erüpsiyonu gelişen 61 yaşındaki bir kadın hasta nadir görülmesi ve klinikte ayırıcı tanısındaki önemi vurgulamak için sunulmuştur.

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Cite This Article

ÜRÜN, M., ARICAN, Ö. (2022). A case of tenoxicam induced generalized (multifocal) bullous fixed drug eruption. Türk Geriatri Dergisi, Cilt: 11 - Sayı: 4, 200–203. https://ajindex.com/articles/624224

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References (9)

  1. Baykal C. ilaç Reaksiyonları. Dermatoloji Atlası’nda. ikinci Baskı. istanbul, ARGOS iletişim Hizmetleri Reklamcılık ve Ticaret Afi, 2004; pp. 236-49
  2. James WD, Berger TG, Elston DM. Contact Dermatitis and Drug Eruptions. In: Andrew’s Diseases of the Skin Clinical Dermatology. Tenth Edition. Canada, WB Saunders Co, 2006; pp: 127-8
  3. Özkaya-Bayazıt E. Specific site involvement in fixed drug eruption. J Am Acad Dermatol, 2003; 49(6): 1003-7
  4. Shear NH, Knowles SR, Shapiro L. Inşammatory disease based on abnormal humoral reactivity and other inşammatory disease. In: Fitzpatrick’s Dermatology in General Medicine. Eds. Wolf K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ. Seventh Edition. New York, McGraw-Hill, 2008; pp: 319-74
  5. Çiçek D, Kandi Coşkun B, Turgut D, Çobanoğlu B. Siproşoksasinin indüklediği bir generalize (multifokal) fiks ilaç erüpsiyonu olgusu. T Klin J Dermatol, 2003; 17(2): 141-4
  6. Habif T. Exanthems and Drug Eruptions. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. Fourth Edition. Philadelphia, Mosby, 2004; pp: 457-98
  7. Horn TD, Hiatt KM. Cutaneous Toxicities of Drugs. In: Lever’s Histopathology of the Skin. Ed. Elder DE, Elenitsas R, Johnson BL, Murphy GF, Nineth Edition. Philadelphia, JB Lippincott Co, 2005; pp: 324-45
  8. Aksungur VL, Alpsoy E, Baykal C, Uzun S. Akut Yaygın Erozyon. Dermatolojide Algoritmik Tanı’da. Birinci Baskı. istanbul, ARGOS iletişim Hizmetleri Reklamcılık ve Ticaret Afi, 2007; pp: 160-3
  9. Wolff K, Johnson RA, Suurmond D. Adverse Cutaneous Drug Reactions. In: Fitzpatrick’s Color Atlas & Synopsis of Clinical Dermatology, Fifth Edition. New York, Mc Graw-Hill, 2005; pp: 542-71.