Journals / Türk Geriatri Dergisi / 2011 / Cilt: 14 - Sayı: 4

Parkinson hastalığında depresyon ve demans

Depression and dementia in parkinson’s disease

Pages
295–299
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, regular mood and cognitive state screening and appropriate treatment should be considered, especially in older PD patients with higher disease severity.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Depression and dementia have been recognized as a common problem in PD.
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Key Findings & Data:Materials and Method: We evaluated retrospectively 240 idiopathic PD patients who responded well to L-dopa treatment.
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Conclusion & Impact:Therefore, regular mood and cognitive state screening and appropriate treatment should be considered, especially in older PD patients with higher disease severity.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Depression and dementia have been recognized as a common problem in PD. However there are debatable results about their nature and frequency of occurrence. Their effects on the PD clinic remain controversial. The aim of our study was to assess the frequency, risk factors, and interrelations between depression and dementia in PD patients. Materials and Method: We evaluated retrospectively 240 idiopathic PD patients who responded well to L-dopa treatment. Severity of disease was evaluated by using UPDRS, HY and WS. HAM-D, MMSE and a socio-demographic questionnaire were also performed on all patients. Results: Our patients (105 females, 135 males) were between 30 and 88 years of age (68.56±10.3). Depression was revealed in 43.6%, and dementia in 33.3%. Patients with dementia were older and had higher depression frequency and WS and UPDRS scores. Depressive patients had higher HY and WS scores also. Positive correlations were detected between disease duration and WS, UPDRS, HY. HAM-D had positive correlations with HY and UPDRS as well. Conclusion: Depression and dementia were correlated with the severity of PD disability. Therefore, regular mood and cognitive state screening and appropriate treatment should be considered, especially in older PD patients with higher disease severity.

Özet

Giriş: Depresyon ve demans Parkinson Hastalığı(PH) için genel bir sorun olarak bilinir. Ancak doğaları ve oluşma sıklıkları net olmayıp PH kliniğine etkileri tartışmalıdır. Çalışmanın amacıPH olanlarda depresyon ve demansın sıklığı, risk faktörleri ve etkileşimlerini değerlendirmektir. Gereç ve Yöntem: İdiopatik PH tanıkriterlerini karşılayan ve L-dopa tedavisine iyi yanıt veren 240 hasta retrospektif değerlendirildi. Hastalık şiddeti UPDRS, Hoehn Yahr (HY) ve Webster skalaları(WS) kullanılarak yapıldı. Ayrıca Hamilton Depresyon skalası(HAM-D), Minimental test ve sosyo-demografik sorgulama her hastaya uygulandı. Bulgular: Hastaların (105 kadın, 135 erkek) yaşları30-88 arası(ortalama 68.56±10.3) idi. Depresyon %43.6 ve demans %33.3 sıklıkla izlendi. Kognitif yetmezliği olan hastalar daha yaşlı ve daha yüksek depresyon sıklığıve WS, UPDRS skorlarına sahipti. Depresif hastalar da depresif olamayan hastalara kıyasla daha yüksek HY ve WS skorlarına sahiptiler. Positive korelasyonlar hastalı k süresi ve WS, UPDRS, HY arasında saptandı. HAM-D skorlarıda HY ve UPDRS ile pozitif korelasyon göstermekteydi. Sonuç: Depresyon ve demans PH yeti yitimi şiddeti ile koreledir. Bu nedenle düzenli duygu durum ve kognitif seviyenin irdelenmesi özellikle yaşlıve ileri PH olan bireylerde uygun tedavinin planlanmasıyönüyle düşünülmelidir

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Cite This Article

AKYOL, A., AKYILDIZ, U., ÖZKUL, A., MEMİŞ, S., TELLİ, E. T., YILMAZ, E. (2022). Parkinson hastalığında depresyon ve demans. Türk Geriatri Dergisi, Cilt: 14 - Sayı: 4, 295–299. https://ajindex.com/articles/624042

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