AI Summary & Key Takeaways
AI InsightConclusion: Further studies in larger and different populations are needed to fully elaborate the involvement of visfatin gene in AD.
📌 3 Key Takeaways
Abstract
Introduction: Visfatin is a pleiotropic cytokine implicated in several physiological and patho- physiological processes such as innate immunity, cellular metabolism, longevity, and inflamma- tion. Altered visfatin levels and visfatin gene polymorphisms have been reported in various human diseases, including type 2 diabetes mellitus, rheumatoid arthritis, obesity, coronary artery disease and stroke. Materials and Method: In this study, we investigated whether serum visfatin levels were changed in volunteers with Alzheimer’s disease (AD) (n = 40) or healthy controls (n=40) and whether visfatin gene G-948T polymorphism was associated with the disease. Results: Visfatin levels were not significantly different in AD patients compared with healthy aged control subjects. In this relatively small population, we found a significant, but weak asso- ciation between GT heterozygous genotype at position -948 of visfatin gene and AD. However, there was no association between G-948T polymorphism and visfatin levels, and any demograph- ic, anthropometric or biochemical parameters. Conclusion: Further studies in larger and different populations are needed to fully elaborate the involvement of visfatin gene in AD.
Özet
Girifl: Visfatin, do¤ufltan immünite, hücre metabolizmas›, uzun yaflam ve inflamasyon gibi pek çok fizyolojik ve patofizyolojik olaya kat›lan bir pleiotropik sitokindir. Yükselen visfatin düze- yi ve visfatin gen polimorfizmlerinin tip 2 diyabet mellitus, romatoid artrit, obezite, koroner arter hastal›¤› ve inme gibi çeflitli hastal›klarla iliflkisi daha önce gösterilmifltir. Gereç ve Yöntem: Çal›flmam›zda; Alzheimer Hastal›¤› tan›s› alm›fl gönüllüler (n=40) ve sa¤- l›kl› kontrollerde (n=40), serum visfatin düzeyinin de¤iflimi ve visfatin G-948T gen polimorfizminin AH’na yatk›nl›ktaki rolü araflt›r›lm›flt›r. Bulgular: AH hastalar›n›n serum visfatin düzeylerinde sa¤l›kl› kontrollere k›yasla anlaml› bir fark bulunamam›flt›r. Bu göreceli küçük grupta; visfatin geninin -948 pozisyonundaki GT hetero- zigot genotipi ile AH aras›nda belirgin ancak zay›f bir iliflki bulunmufltur. Ancak yine de G-948T polimorfizmi ile serum visfatin düzeyleri, veya herhangi bir demografik, antropometrik ya da bi- yokimyasal veri aras›nda bir iliflki bulunamam›flt›r. Sonuç: Visfatinin AH ile iliflkisini kesin olarak belirleyebilmek için daha genifl ve farkl› popu- lasyonlarda yap›lacak ileri araflt›rmalara ihtiyaç duyulmaktad›r.