MİKOZİS FUNGOİDES VE MANTLE CELL LENFOMA BİRLİKTELİĞİ: OLGU SUNUMU

Objective & Hypothesis:Mycosis fungoides (MF) is the most common type of primary non-Hodgkin cutaneous T-celllymphoma and typically presents with a patch or plaque lesion with variable progression totumors and extracutaneous involvement.

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Key Findings & Data:Epidemiological studies have indicated that patientswith MF are at a high risk for the development of secondary lymphomas.However, although some of these studies have reported an increased risk for NHL, Hodgkindisease (HD) remains the most common type of secondary lymphoma in patients with MF inother studies.In this report, we describe a 76-year-old male patient with MF (stage IA) who was concomitantly diagnosed with mantle cell lymphoma (MCL).

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Conclusion & Impact:Histopathologic and immunophenotypic features as well as cyclin D1 oncogene and chromosomal aberrations were subsequently identified.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Mycosis fungoides (MF) is the most common type of primary non-Hodgkin cutaneous T-celllymphoma and typically presents with a patch or plaque lesion with variable progression totumors and extracutaneous involvement. Epidemiological studies have indicated that patientswith MF are at a high risk for the development of secondary lymphomas.However, although some of these studies have reported an increased risk for NHL, Hodgkindisease (HD) remains the most common type of secondary lymphoma in patients with MF inother studies.In this report, we describe a 76-year-old male patient with MF (stage IA) who was concomitantly diagnosed with mantle cell lymphoma (MCL). Histopathologic and immunophenotypic features as well as cyclin D1 oncogene and chromosomal aberrations were subsequently identified.

Özet

Mikozis fungoides (MF) en sık görülen primer T hücreli non-Hodgkin kutanöz lenfoma olup, tipik olarak yama, plak ve tümörler ile, nadiren de ekstrakutanöz organ tutulumuyla karakterizedir. Epidemiyolojik çalışmalar MF tanısı alan hastalarda sekonder lenfoma gelişme riskinin artmış olduğuna dikkat çekmektedir.Bu çalışmalardan bazılarında MF'ye eşlik eden en sık görülen sekonder lenfoma tipi Hodgkinlenfoma (HL) iken, diğer çalışmalar özellikle non-Hodgkin lenfoma (NHL) için risk artışı olduğunubildirmektedir. Bu olgu sunumunda Mantle cell lenfoma (MCL) tanısı alan evre IA MF nedeni iletakip edilen 74 yaşındaki erkek hastanın histopatolojik, immünfenotipik, cyclin D1 onkogen vekromozomal değişiklik özellikleri tanımlanmıştır.

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Cite This Article

ÖKTEM, A., CERAN, F., ÜNAL, D. T., GENÇ, İ., ÇİFTÇİ, A. Y., ARTÜZ, F. (2022). MİKOZİS FUNGOİDES VE MANTLE CELL LENFOMA BİRLİKTELİĞİ: OLGU SUNUMU. Türk Geriatri Dergisi, Cilt: 19 - Sayı: 1, 50–53. https://ajindex.com/articles/623778

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