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Journals / Türk Geriatri Dergisi / 2019 / Cilt: 22 - Sayı: 3

IMPACT OF SUBCLINICAL HYPOTHYROIDISM ON FREQUENCY OF PREMATURE VENTRICULAR CONTRACTIONS IN ELDERLY PATIENTS WITHOUT STRUCTURAL HEART DISEASE

YAPISAL KALP HASTALIĞI OLMAYAN YAŞLI HASTALARDA SUBKLINIK HIPOTIROIDIZMIN ERKEN VENTRIKÜLER KONTRAKSIYON SIKLIĞI ÜZERINE ETKISI

Firdevs Ayşenur EKİZLER
Bahar TEKİN TAK
Pages
276–286
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

We concludedthat serum TSH concentration has a role in the frequency of PVC, therefore, SH may lead to apredisposition to ventricular arrhythmias.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Premature ventricular contractions (PVCs) are common arrhythmias, most of themrequiring no follow-up or treatment.
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Key Findings & Data:Subclinical hypothyroidism (SH) is defined as normal levelsof free triiodothyronine (FT3) and free thyroxine (FT4), with elevation of serum thyroid stimulatinghormone (TSH) levels (>4.2 mIU/l).
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Conclusion & Impact:We concludedthat serum TSH concentration has a role in the frequency of PVC, therefore, SH may lead to apredisposition to ventricular arrhythmias.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Premature ventricular contractions (PVCs) are common arrhythmias, most of themrequiring no follow-up or treatment. Subclinical hypothyroidism (SH) is defined as normal levelsof free triiodothyronine (FT3) and free thyroxine (FT4), with elevation of serum thyroid stimulatinghormone (TSH) levels (>4.2 mIU/l). We aimed to demonstrate the association of SH with the frequencyof PVCs in elderly patients without structural heart disease.Materials and Method: We included 327 consecutive elderly patients who underwent 24-hourHolter monitoring for the frequency of PVCs. The patients were initially divided into two groups withrespect to the presence of SH. Later, the patients were divided into three groups with respect to thefrequency of PVCs, with groups 1, 2 and 3 representing PVCs (10,000/day), respectively.Results: A total of 28 patients had SH. Number of PVCs was significantly higher in patients withSH (13104.7 ± 7007 vs 9286.7 ± 7724, p = 0.012) than in those without SH. On comparing the groupsbased on the frequency of PVCs, TSH levels were significantly higher in group 3 patients (>10,000PVCs/day) than those in the others (p < 0.001). The percentage of patients with SH was significantlyhigher in group 3 (p = 0.005). According to univariate and multivariate analysis, SH was found to bean independent predictor of PVCs.Conclusion: We found that SH is independently associated with frequent PVCs. We concludedthat serum TSH concentration has a role in the frequency of PVC, therefore, SH may lead to apredisposition to ventricular arrhythmias.

Özet

Giriş: Prematür ventriküler kontraksiyonlar (PVK) sık görülür ve yapısal kalp hastalığı yokluğunda çoğu takip ve tedavi gerektirmez. Subklinik hipotroidi (SH), tiroid stimülan hormon yüksekliği (TSH>4.2 mIU/l) mevcutken serbest triiyodotironin(fT3) ve serbest tiroksin(fT4) düzeylerinin normal olduğu ve hipotirodizmin aşikar klinik bulgularının olmadığı durum olarak tanımlanır. Biz bu çalışmada yapısal kalp hastalığı olmayanlarda SH varlığının sık PVK ile ilişkili olup olmadığını araştırmayı amaçladık Gereç ve Yöntem: Bu çalışmaya 24 saatlik holter monitorizasyonu (HM) ile PVK saptanan 327 geriatrik hasta dahil edildi. Öncelikle hastalar SH varlığına göre 2 gruba, sonrasında da PVK sıklığına göre 3 gruba ayrıldı. PVK sıkılığına göre sırasıyla grup 1 (10000 PVK/gün) olarak tanımlandı. Bulgular: Toplam 327 geriatrik hastanın 28’inde SH mevcuttu. SH olan hastalarda olmayanlara kıyasla PVK sayısı anlamlı olarak yüksek bulundu ( 13104.7±7007 vs. 9286.7±7724, p=0.012). PVK sıklığı ile yapılan gruplandırmaya göre, grup 3’te (>10000 PVK/gün) TSH düzeyleri anlamlı olarak yüksek bulundu (p

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Cite This Article

EKİZLER, F. A., TAK, B. T. (2022). IMPACT OF SUBCLINICAL HYPOTHYROIDISM ON FREQUENCY OF PREMATURE VENTRICULAR CONTRACTIONS IN ELDERLY PATIENTS WITHOUT STRUCTURAL HEART DISEASE. Türk Geriatri Dergisi, Cilt: 22 - Sayı: 3, 276–286. https://ajindex.com/articles/623625

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