Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 1999 / Cilt: 33 - Sayı: 1

The comperative study for the topical efficacy of 20% azelaic acid+0.25% tretinoin combination,20 % azelaic acid ,0.25% tretinoin, 4% hydroquinone and sunscreen (SPF 15) groups in melasma treatment

Melazma tedavisinde topik %20 azelaik asit-%0.25 tretinoin kombinasyonu, %20 azelaik asit, %0.25 tretinoin, %4 hidrokinon ve SPF15 güneşten koruyucu uygulamalarının etkinliğinin karşılaştırılması

Pages
25–28
Publication Date
2022-11-05
DOI
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Results: There was no statistical differences betvveen topical 4% hydroquinone, 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination when these groups are eva/uated vvith their lesion severity index behre treatment and after treatment (p>0.05).Thus, the pigmentation index of these groups are compared, there was no difference betvveen 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination but these groups were more effective when compared to 4% hydroquinone alone (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Melasma is a dermatosis characterized by symmetric, hyperpigmented macules, which is located on the areas that exposed to UV light such as forehead, malar prominences, upper lip and less freçuently on the forearms an legs.
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Key Findings & Data:Patients and method: İn our study, the topical efficacy of the 20 % azelaic acid+0.25 % tretinoin combination, 20 % azelaic acid, 0.25 % tretinoin, 4% hydroquinone and sunscreen (SPF 15) groups; are studied comperatively for six to eleven months in melasma treatment.
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Conclusion & Impact:Results: There was no statistical differences betvveen topical 4% hydroquinone, 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination when these groups are eva/uated vvith their lesion severity index behre treatment and after treatment (p>0.05).Thus, the pigmentation index of these groups are compared, there was no difference betvveen 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination but these groups were more effective when compared to 4% hydroquinone alone (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Melasma is a dermatosis characterized by symmetric, hyperpigmented macules, which is located on the areas that exposed to UV light such as forehead, malar prominences, upper lip and less freçuently on the forearms an legs. Patients and method: İn our study, the topical efficacy of the 20 % azelaic acid+0.25 % tretinoin combination, 20 % azelaic acid, 0.25 % tretinoin, 4% hydroquinone and sunscreen (SPF 15) groups; are studied comperatively for six to eleven months in melasma treatment. Results: There was no statistical differences betvveen topical 4% hydroquinone, 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination when these groups are eva/uated vvith their lesion severity index behre treatment and after treatment (p>0.05).Thus, the pigmentation index of these groups are compared, there was no difference betvveen 20% azelaic acid, 0.25% tretinoin and 20% azelaic acid+0.25% tretinoin combination but these groups were more effective when compared to 4% hydroquinone alone (p

Özet

Melazma, yüzde UV ile sık sık karşı karşıya kalınan bölgelerde ve nadiren önkolda görülen simetrik hiperpigmente makuller ile karakterize bir dermatozdur. Araştırmamızda melazma tedavisinde topik 0/o20 azelaik asit+%0.25 tretinoin kombinasyonu, 0/o20 azelaik asit, %0.25 tretinoin, 0/o4 hidrokinon ve SPF 15 güneşten koruyucu kullanılan grupların etkinlikleri birbirleri ile karşılaştırıldı. Topik %4 hidrokinon, %20 azelaik asit, %0.25 tretinoin ve %20 azelaik asit+% 0.25 tretinoin uygu/anan gruplar arasında tedavi öncesi ve tedavi sonrasında lezyon genişlik oranları arasındaki fark istatistiksel olarak anlamlı bulunmadı (p>0.05). Öte yandan tedavi öncesi ve tedavi sonrasında pigmentasyon skorları incelendiğinde arasındaki fark %20 azelaik asit, %0.25 tretinoin ve %20 azelaik asit+%0.25 tretinoin grupları arasında istatistiksel olarak anlamlı bulunmazken (p>0.05), bu üç grubun da %4 hidrokinon ile karşılaştırıldığında pigmentasyon skorundaki gerilemede istatistiksel o/arak anlamlı ölçüde daha etkin oldukları gözlendi (p

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Cite This Article

ANADOLU, R., GÜRGEY, E., TÜRSEN, Ü., ÇALIKOĞLU, E. (2022). The comperative study for the topical efficacy of 20% azelaic acid+0.25% tretinoin combination,20 % azelaic acid ,0.25% tretinoin, 4% hydroquinone and sunscreen (SPF 15) groups in melasma treatment. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 33 - Sayı: 1, 25–28. https://ajindex.com/articles/622368

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