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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2002 / Cilt: 36 - Sayı: 4

Leg ulcer due to protein C resistance: Report of a case

Protein C rezistansına bağlı olarak gelişen bacak ülseri: Bir olgu sunumu

Mete Arzu KAYNAK
Burhan ENGİN
Oya OĞUZ
Burhan FERHANOĞLU
Pages
280–283
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The algorythmic approach to investigate the etiopathology of the leg ulcers is emphasized.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Venous leg ulcerations are mostly caused by chronic venous insuffeciency dealing with trauma, thrombophlebitis or thrombotic syndrome.
📊
Key Findings & Data:Here we present a 23-year-old male patient with factor V Leiden mutation and activated protein C resistance.
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Conclusion & Impact:The algorythmic approach to investigate the etiopathology of the leg ulcers is emphasized.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Venous leg ulcerations are mostly caused by chronic venous insuffeciency dealing with trauma, thrombophlebitis or thrombotic syndrome. Various risk factors have been identified for the development of deep venous thrombosis. Activated protein C resistance has recently emerged as one of the most frequent causes of venous thrombosis. Activated protein C cannot inactivate thrombosis formation in the factor V Leiden mutation. Here we present a 23-year-old male patient with factor V Leiden mutation and activated protein C resistance. The algorythmic approach to investigate the etiopathology of the leg ulcers is emphasized.

Özet

Bacak ülserleri büyük çoğunlukla tromboflebit veya trombotik sendromlar nedeniyle gelişen kronik venöz yetmezliğe bağlıdır. Derin venöz trombozun gelişimi için birçok risk faktörü tanımlanmıştır. Son zamanlarda derin ven trombozuna en sık neden olan faktörlerden biri olarak aktive protein C rezistansı üzerinde durulmaktadır. Trombus oluşumunu önleyen bir faktör olan aktive protein C, faktör V Leiden mutasyonunda bu işlevini yerine getiremez. Bu yazıda faktör V Leiden mutasyonuna bağlı aktive protein C rezistansı saptanan 23 yaşında bir erkek olgu sunulmakta ve bacak ülserlerinin etyopatogenezinin araştırılmasında izlenmesi gereken yol vurgulanmaktadır

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Cite This Article

KAYNAK, M. A., ENGİN, B., OĞUZ, O., FERHANOĞLU, B. (2022). Leg ulcer due to protein C resistance: Report of a case. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 36 - Sayı: 4, 280–283. https://ajindex.com/articles/622284

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