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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2015 / Cilt: 49 - Sayı: 1

Evaluation of 25 hydroxy vitamin D3 levels in patients with alopecia areata

Alopesi areatalı hastalarda 25 hidroksi vitamin D3 düzeyinin değerlendirilmesi

Nermin BOYRAZ
Seval KARASATI
Arzu TOĞRAL KARATAŞ
Atiye OĞRUM
Hatice Meral EKŞİOĞLU
Pages
50–53
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, it may also indicate that the relationship between AA and Vitamin D is not via the level but vitamin D receptor (number and/or structure).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Current studies link vitamin D deficiency with many autoimmune diseases.
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Key Findings & Data:Materials and Methods: 25-hydroxyvitamin D [25(OH)D] levels in 40 patients with alopecia areata and age, gender and skin phototypematched healthy controls were evaluated.
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Conclusion & Impact:However, it may also indicate that the relationship between AA and Vitamin D is not via the level but vitamin D receptor (number and/or structure).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Current studies link vitamin D deficiency with many autoimmune diseases. Alopecia areata (AA) is a common autoimmune dermatological disease. The aim of this study was to investigate the relationship between vitamin D levels and alopecia areata. Materials and Methods: 25-hydroxyvitamin D [25(OH)D] levels in 40 patients with alopecia areata and age, gender and skin phototypematched healthy controls were evaluated. Serum 25(OH)D levels were measured in all subjects and grouped as normal/sufficient (>30 ng/ml), insufficient (15-30 ng/ml) and deficient (0.05). In both groups 97.5% of patients had 25(OH)D levels below the normal range. Conclusion: Vitamin D levels in patients with AA were similar to those in the controls. This similarity may suggest that there is no relationship between vitamin D and AA. However, it may also indicate that the relationship between AA and Vitamin D is not via the level but vitamin D receptor (number and/or structure).

Özet

Amaç: Yapılan çalışmalarda vitamin D eksikliği ile birçok otoimmün hastalık arasında muhtemel bir ilişki gözlenmiştir. Bu çalışmada sık görülen otoimmün dermatolojik bir hastalık olan alopesi areata (AA) ile D vitamini düzeyi arasındaki ilişkinin araştırılması amaçlandı. Gereç ve Yöntem: AA tanısı alan 40 hasta ile ile yaş grubu, cinsiyet ve deri fenotipi eşleştirilmiş 40 kişilik kontrol grubunun 25 hidroksi vitamin D3 (25 OH D) düzeyleri karşılaştırıldı. Tüm hastaların 25 OH D düzeyleri ölçüldü ve normal (>30 ng/ml), eksik (15-30 ng/ml) ve yetersiz(0,05). Her iki grupta da 25 OH D düzeyi normalin altında saptanan hasta oranı %97,5ti. Sonuç: Çalışmada AAlı hastalar ve kontrol grubunun vitamin D düzeyleri benzerdi. Bu benzerlik AA ile vitamin D arasında bağlantı olmadığına işaret ediyor olabilir. Ancak AA ve Vit D arasındaki ilişkinin Vitamin D düzeyi değil Vitamin D reseptörü (sayı ve/veya yapı) üzerinden olmasından da kaynaklanabilir.

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Cite This Article

BOYRAZ, N., KARASATI, S., KARATAŞ, A. T., OĞRUM, A., EKŞİOĞLU, H. M. (2022). Evaluation of 25 hydroxy vitamin D3 levels in patients with alopecia areata. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 49 - Sayı: 1, 50–53. https://ajindex.com/articles/622276

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References (15)

  1. Madani S, Shapiro J: Alopecia areata update. J Am Acad Dermatol 2000;42:549-66
  2. Reichrath J, Schilli M, Kerber A, Bahmer FA, Czarnetzki BM, Paus R: Hair follicle expression of 1,25-dihydroxyvitamin d3 receptors during the murine hair cycle. Br J Dermatol 1994;131:477-82
  3. Cantorna MT: Vitamin D and autoimmunity: Is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med 2000;223:230-3
  4. Cantorna MT: Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol 2006;92:60-4
  5. Sakai Y, Kishimoto J, Demay MB: Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice. J Clin Invest 2001;107:961- 6
  6. Forghani N, Lum C, Krishnan S, Wang J, et al: Two new unrelated cases of hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from the same novel nonsense mutation in the vitamin D receptor gene. J Pediatr Endocrinol Metab 2010;23:843-50
  7. Xie Z, Komuves L, Yu QC, et al: Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 2002;118:11-6
  8. Yilmaz N, Serarslan G, Gokce C: Vitamin D concentrations are decreased in patients with alopecia areata. Vitamins & Trace Elements 2012;1:105-9. 9. d'Ovidio R, Vessio M, d'Ovidio FD: Reduced level of 25-hydroxyvitamin D in chronic/relapsing alopecia areata. Dermatoendocrinol 2013;5:271-3. 10. d’Ovidio R, d’Ovidio F: Recidive stagionali dell’alopecia areata. G Ital Dermatol Venereol 1995;295:130-4
  9. Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol 2011;91:115-24
  10. Mathews CH, Brommage R, DeLuca HF: Role of vitamin D in neonatal skeletal development in rats. Am J Physiol 1986;250:E725-3013
  11. Beer S, Tieder M, Kohelet D, et al: Vitamin D resistant rickets with alopecia: A form of end organ resistance to 1,25 dihydroxy vitamin D. Clin Endocrinol 1981;14:395-402
  12. Pavlovitch JH, Galoppin L, Rizk M, Didierjean L, Balsan S: Alterations in rat epidermis provoked by chronic vitamin D deficiency. Am J Physiol 1984;247:E228-33
  13. Li YC, Pirro AE, Amling M, et al: Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type with alopecia. Proc Natl Acad Sci USA 1997;94:9831-5
  14. Kim DH, Lee JW, Kim IS, et al: Successful treatment of alopecia areata with topical calcipotriol. Ann Dermatol 2012;24:341-4
  15. Akar A, Orkunoglu F